The objective of this study was to investigate the efficacy treatment strategies in patients with adenocarcinoma (AC) cervix and compare it those squamous cell carcinoma (SCC) cervix. Women FIGO (1994) stage IB1 AC, especially pathologic tumor size 2-4 cm, treated class III hysterectomy, were compared SCC comparable strategy a case-controlled study. Eighty (20 cases, 60 controls) analyzed. Lymphvascular space invasion (P = 0.01) lymph node metastasis 0.07) more frequent than AC. However,...

MicroRNA (miRNA) has a critical effect on tumorigenesis through post‐transcriptional modification and is considered to be potential biomarkers for cancer diagnosis treatment monitoring. We evaluated the expression pattern of three selected miRNAs (miR‐21, miR‐155, let‐7a) evaluate their roles by quantitative reverse transcription‐polymerase chain reaction using formalin‐fixed paraffin‐embedded tissues 63 surgically resected pulmonary neuroendocrine (NE) tumors (19 typical carcinoids (TCs), 6...

Abstract The aim of this study was to compare human epidermal growth factor 2 ( HER 2) status in primary colorectal cancer and paired liver or lung metastasis. Gene amplification has been intensively evaluated contemporary oncology, especially breast stomach cancer. knowledge metastatic sites may be potential value for therapeutic decision making colon assessed by fluorescence situ hybridization FISH ) immunohistochemistry IHC 94 with corresponding metastases. present 19 the 188 (10.1%) both...

Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) have been reported to be related certain clinical characteristics (i.e., female, non-smokers with adenocarcinoma) and gefitinib responsiveness.This exploratory analysis was performed determine the incidence of EGFR male smokers squamous carcinoma, who were treated tyrosine kinase inhibitor, gefitinib.Sixty-nine Korean NSCLC patients a prospective study.For subset 20 carcinoma history smoking, pretreatment...

Background:The decrease in incidence of cervical dysplasia and carcinoma has not been as dramatic expected with the development improved research tools test methods.The human papillomavirus (HPV) alone suggested for screening some countries.The National Cancer Screening Project Korea applied Papanicolaou smears (Pap smears) method carcinoma.We evaluated value Pap smear HPV testing diagnostic a single institution.Methods: Patients co-tested simultaneously or within one month each other were...

Background Rapid and accurate identification of large vessel occlusion (LVO) is crucial for determining eligibility endovascular treatment. We aimed to validate whether computed tomography combined with clinical information (CT&CI) or diffusion-weighted imaging (DWI) offers better predictive accuracy anterior circulation LVO. Methods Computed DWI data from patients diagnosed acute ischemic stroke were collected. Three deep-learning models, convolutional neural network, EfficientNet-B2,...

Abstract Solute carrier family (SLC) transporters are expressed in the digestive system and play important roles maintaining physiological functions body. In addition, SLC act as oncoproteins or tumor-suppressor proteins during development, progression, metastasis of various cancers. SLC22A18, a member SLC22 gene family, is an orphan transporter with unknown endogenous substrate. Previous study revealed that SLC22A18 downregulated colorectal cancer tissues it acts suppressor cancer, although...

The objective of this study was to determine whether the depth invasion related lymph vascular space (LVSI) and node metastasis there a correlation between LVSI in stage IA cervical cancer. medical records, including surgical notes pathologic reports, 202 patients with microinvasive squamous cell carcinoma uterine cervix were reviewed retrospectively. There positive LVSI, incidence slightly higher than those reported hitherto for IA1 cancer, especially 1-3 mm group. However, among four...

The aim of this study was to compare the outcome chemotherapy or radiation as adjuvant therapy for patients with FIGO stage IB–IIA cervical cancer and surgically confirmed intermediate risk factors. Data were collected from uterine who had following radical hysterectomy pelvic lymph node dissection (RHLND, cases) radiotherapy RHLND (controls). groups consisted 38 cases 42 controls. Adjuvant treatment given a combination factors including deep stromal invasion (>50%), lymphvascular space...

Local endometrial stem cells play an important role in regulating thickness, which is essential factor for successful embryo implantation and pregnancy outcomes. Importantly, defects cell function can be responsible thin endometrium subsequent recurrent losses. Therefore, many researchers have directed their efforts toward finding a novel stimulatory that enhance the regenerative capacity of cells. Sonic hedgehog (SHH) morphogen plays key pattern formation throughout embryonic limb...

Background & AimsThe development of nonalcoholic fatty liver disease (NAFLD) can be modulated by microRNAs (miRNA). Dietary polyphenols modulate the expression miRNA such as miR-467b-3p in liver. In addition, 6-gingerol (6-G), functional polyphenol ginger, has been reported to ameliorate hepatic steatosis; however, exact mechanism involved and role remain elusive. this study, we assessed pathogenesis steatosis regulation 6-G through hepatocyte nuclear factor 4α (HNF4α).MethodsmiR-467b-3p was...

Pulmonary neuroendocrine (NE) tumors represent four subgroups with different biologic behavior, from low-grade typical carcinoid and intermediate-grade atypical to high-grade small cell lung carcinoma (SCLC) large NE carcinomas (LCNEC).These subtypes are classified according morphologies observed by hematoxylin eosin (H&E) staining, as detailed in the 2004 World Health Organization (WHO) classification. 1 LCNEC of was first introduced 1991 Travis et al., 2 who proposed it be a distinct...

Solute carrier 40A1 (SLC40A1) encodes ferroportin, which is the only known transmembrane protein that exports elemental iron from mammalian cells and essential for homeostasis.Mutations in SLC40A1 are associated with ironoverload disorders.In addition to ferroportin diseases, expression downregulated various cancer types.Despite clinical significance of transporter, a few studies have investigated genetic variants SLC40A1.The present study was performed identify variations promoter...

The differentiation of malignant mesotheliomas and benign mesothelial proliferations is crucial in determining patient care prognosis. But, this distinction can be extremely difficult, particularly small biopsies. Recently, insulin‐like growth factor II mRNA ‐binding protein 3 ( IMP3 ) glucose transporter 1 GLUT ‐1) have been reported as specific sensitive markers the from proliferations. purpose study to evaluate utility , ‐1, epithelial membrane antigen EMA immunohistochemistry for...

Background Tumour-unrelated, virus-specific bystander CD8 + T cells were recently shown to be abundant among tumour-infiltrating lymphocytes (TILs). However, their roles in tumour immunity have not been elucidated yet. Methods We studied the characteristics of TILs from non-small cell lung cancer (NSCLC) tissues (N=66) and activation by interleukin (IL)-15 repurpose them for immunotherapy. Results show that specific various viruses are present human NSCLC tissues. stimulated ex vivo using...

The mutations that occur in the p53 tumor suppressor gene have been studied various human malignant tumors. However, little is known about this meningiomas. To investigate relationship and frequency of mutations, polymerase chain reaction-single stranded conformational polymorphism (PCR-SSCP) immunohistochemical study were performed on 41 intracranial meningiomas (21 benign, 11 atypical, 9 malignant). higher protein expression rate, poorer histologic grade (9.5%, 72.7%, 88.9% atypical...

Herein, we report a case of micronodular thymoma with lymphoid stroma in previously healthy 73-year-old male. Thymectomy was performed. The solid and macrocystic masses were encapsulated focal invasion. portion consisted nodules bland-looking spindle or round epithelial cells containing prominent germinal centers. had moderate amount cytoplasm occasional mucin production. cystic lined cuboidal epithelium. According to World Health Organization (WHO) classification, the mass diagnosed as...

Stafne bone cavity is a well demarcated defect of the mandible, usually asymptomatic and located in posterior portion bone.1 Most cases have been reported male patients between age 50 70 years.2 This lesion has labeled with various terms, including ectopic salivary gland, idiopathic defect, mandibular gland inclusion, cyst.2 The cavities are often filled normal tissue, but occasional showed contents that included skeletal muscle, fibrous connective tissue adipose tissue.1,2 Bilateral...

Ha S Y, Lee C H, Chang H K, S, Kwon K E Roh M & Seo B (2012) Histopathology 60, 731–739 Differential expression of forkhead box M1 and its downstream cyclin‐dependent kinase inhibitors p27 kip1 p21 waf1/cip1 in the diagnosis pulmonary neuroendocrine tumours Aims: Pulmonary (NE) represent a spectrum phenotypically distinct entities with different biological behaviours. Difficulties classifying these are frequently encountered clinical practice. Forkhead (FoxM1) is essential for...

Background: Human papillomavirus (HPV) is an oncogenic virus in cervical cancer and most invasive carcinomas (ICs) are caused by HPV16 18.However, the roles contributions of other uncommon rare genotypes remain uncertain.Methods: HPV were retrospectively assessed using DNA chip that can specify up to 32 genotypes.We arbitrarily regarded accounting for less than 6% total as genotypes.Results: A 3,164 HPV-positive cases enrolled.In groups 2A, 2B, 3, unclassified genotypes, 2.4% with (68, 26,...