A5024231413- Genomics and Phylogenetic Studies
- Immune Cell Function and Interaction
- Insect symbiosis and bacterial influences
- T-cell and B-cell Immunology
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Entomopathogenic Microorganisms in Pest Control
- Coleoptera Taxonomy and Distribution
- Microbial Natural Products and Biosynthesis
- MicroRNA in disease regulation
- Biochemical and Structural Characterization
- Insect Resistance and Genetics
- Microbial Metabolism and Applications
- Cancer Cells and Metastasis
- Forest Insect Ecology and Management
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Biofuel production and bioconversion
- Single-cell and spatial transcriptomics
- RNA regulation and disease
Nationwide Children's Hospital
2025
National Institutes of Health
2021-2024
National Cancer Institute
2021-2024
Center for Cancer Research
2024
Shanxi Agricultural University
2007-2023
University of Pennsylvania
2020
Shanxi University of Traditional Chinese Medicine
2007
Therapeutic resistance remains a persistent challenge for patients with malignant tumors. Here, we reveal that endothelial cells (ECs) acquire transformation into mesenchymal stem cell (MSC)-like in glioblastoma (GBM), driving tumor to cytotoxic treatment. Transcriptome analysis by RNA sequencing (RNA-seq) revealed ECs undergo and stemness-like activation GBM microenvironment. Furthermore, identified c-Met-mediated axis induces β-catenin phosphorylation at Ser675 Wnt signaling activation,...
CRISPR-Cas technology has transformed functional genomics, yet understanding of how individual exons differentially shape cellular phenotypes remains limited. Here, we optimized and conducted massively parallel exon deletion splice-site mutation screens in human cell lines to identify that regulate fitness. Fitness-promoting are prevalent essential highly expressed genes commonly overlap with protein domains interaction interfaces. Conversely, fitness-suppressing enriched nonessential genes,...
Uncovering mechanisms and predicting tumor cell responses to CAR-NK cytotoxicity is essential for improving therapeutic efficacy. Currently, the complexity of these effector-target interactions donor-to-donor variations in NK receptor (NKR) repertoire require functional assays be performed experimentally each manufactured product target combination. Here, we developed a computational mechanistic multiscale model which considers heterogenous expression CARs, NKRs, adhesion receptors their...
The first complete mitochondrial genome of Lixus subtilis Boheman is reported in this study. circular 15,223 bp long, including a standard set 21 transfer RNAs (tRNAs), 2 ribosomal (rRNAs), 13 protein-coding genes, and non-coding control region. trnI gene was not found the L. mitogenome. All tRNAs had typical cloverleaf structure, except for trnS1, which lacked dihydrouridine arm. phylogenetic tree Curculionidae species based on concatenated nucleotide sequences genomes strongly supported...
Abstract Background: Tetanops sintenisi is a pest that mainly damages the roots of quinoa ( Chenopodium ) and it first discovered in China 2018. Methods Results: Here, complete mitochondrial genome (mitogenome) T. was sequenced compared with mitogenomes other Diptera species. The results revealed mitogenome 15763 bp length (GenBank accession number: MT795181) comprised 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, 2 ribosomal non-coding A+T-rich region (959 bp). highly...