OBJECTIVE--To see whether a prepregnancy clinic for diabetic women can achieve tight glycaemic control in early pregnancy and so reduce the high incidence of major congenital malformation that occurs infants these women. DESIGN--An analysis including record severe hypoglycaemic episodes relation to occurrence among infants. SETTING--A combined antenatal teaching hospital. PATIENTS--143 Insulin dependent attending 96 insulin managed over same period who had not received specific care. MAIN...

The hazards associated with pregnancy in the insulin-dependent diabetic have altered considerably within past 60 years.1 Nowadays there is rarely a serious risk to life or health of mother, while "classical" grotesquely obese offspring, prone respiratory distress syndrome and dangerous metabolic disturbance neonatal period, seldom encountered.The frequency severe congenital abnormalities, however, does not appear declined, this now constitutes major target for further improvement management...

Serial measurements of the MB isoenzyme creatine kinase, total aspartate mainotransferase, and urea stable lactate dehydrogenase have been made in serum a series 139 patients admitted with diagnosis suspected myocardial infarction. Serum also on postoperative surgical medical disorders known to caused raised kinase activity. All these enzymes were abnormal at least one specimen from all electrocardiographically proved acute The magnitude rise was 2 3 times greater than that any other...

High-molecular-mass alkaline phosphatase has similar properties in serum and bile. It is of sufficiently large size to be excluded by Sepharose 6B carries a high negative charge at pH, largely accounted for the presence sialic acid residues. slightly more heat labile than lower-molecular-mass liver isoenzyme. Other enzymes originating from hepatocyte plasma membrane are present as high-molecular-mass forms normal bile, both bile patients with disease. The activities these relatively enzymic...

Objective: The aim was to examine the influence of cardiopulmonary bypass on brain natriuretic peptide (BNP) and hormones importance in control sodium water balance blood volume. Methods: Nine patients (mean age 4 years, range 2-9) undergoing cardiac surgery were studied. Blood samples taken before, during, up 24 h after bypass. Plasma levels BNP, atrial (ANP), arginine vasopressin (AVP), plasma renin activity, aldosterone, catecholamines measured. Results: Preoperative concentrations BNP...

Serum creatine kinas (C.K.), aspartate amino-transferase (G.O.T.), and alkaline phosphatase (A.P.) activities were measured in 211 men with serum cholesterol concentrations the upper one-third of normal distribution. Of these, 110 receiving clofibrate 101 given identical capsules containing olive oil. These investigations also carried out on 85 healthy low levels not clofibrate. No differences observed C.K. G.O.T. between any these groups; A.P. was significantly lower clofibrate-treated...

Duodenal calcium and magnesium concentrations after pancreatic stimulation were measured in 25 patients with without disease. The concentration of both ions was higher those disease, furthermore these showed a different secretory pattern. These findings may be relevant to the aetiology pancreatitis calcification, might diagnostic value.

Laparoscopy and laparoscopic ultrasonography (lapUS) have been shown to improve the staging of patients with oesophagogastric cancer but there remains doubt as whether most benefit follows laparoscopy alone how much is contributed by addition lapUS.The role lapUS in surgical decision making was evaluated prospectively a consecutive series following conventional radiological assessment. The results findings over above were documented order identify additional lapUS.After initial assessment 41...

Using immunoelectrophoresis and other techniques, we have demonstrated an association between lipoprotein-X (a) alkaline phosphatase (b) enzymes originating from the hepatocyte membrane, namely gamma-glutamyltransferase leucine aminopeptidase. The high-molecular-mass forms of these enzymes, in both serum bile, were precipitated by antiserum but not antisera to plasma proteins. activity was positively correlated with lipoprotein-X-associated phosphatase, assessed semi-quantitatively. On hand,...

A validation study of children's dietary reporting provided an opportunity to investigate whether cognitive ability is a source systematic error in recalls. From the fall 2004 through spring 2007, fourth-grade children (n = 374) Columbia, South Carolina, were observed eating school meals and interviewed obtain 24-hour recalls; subsequently, measures calculated. The common factor extracted from 4 subject-area achievement tests (scores on which by district for 362 children) was used as measure...

Fifty consecutive patients undergoing coronary artery bypass grafting for chronic stable angina were assessed by serial electrocardiography, preoperative and postoperative myocardial scanning with technetium-99m pyrophosphate, gated radionuclide ventriculography, measurement of creatine kinase, aspartate aminotransferase, urea lactic dehydrogenase, kinase isoenzyme (MB) to assess the incidence perioperative infarction identify most appropriate diagnostic techniques. The correlation between...

In 1974 a project was initiated in which patients with apparently operable breast carcinoma underwent special investigations an attempt to identify occult metastasis bone and liver. One hundred seventy-two have been followed for two years or more their axillary node histological findings reviewed. From analysis of these the following conclusions may be drawn. Careful clinical assessment, especially measurement primary tumour palpation nodes, remains fundamental guide likelihood early...

Journal Article Is the investigation of patients with breast cancer for occult metastatic disease worth while? Get access A P M Forrest, Forrest Departments Clinical Surgery, Radiation Oncology, Medical Radiology, Chemistry and Pathology, University Edinburgh Search other works by this author on: Oxford Academic Google Scholar Elizabeth L Cant, Cant Maureen Roberts, Roberts Helen J Stewart, Stewart D Sumerling, Sumerling Donaldson, Donaldson F Smith, Smith Shivas British Volume 66, Issue 10,...

Concentrations of total glycosylated haemoglobins (Hb A1) were measured in 40 diabetics at diagnosis and monthly intervals after treatment with chlorpropamide, insulin, or diet alone was begun. The mean Hb A1 concentration presentation 16 patients treated chlorpropamide significantly higher than that 12 the duration glycaemic symptoms much longer chlorpropamide-treated group. In contrast, plasma glucose similar both groups. concentrations by lower those other two groups, most these free...

To determine the changes in endocrine mechanisms of fluid balance after cardiopulmonary bypass children.Prospective study; analysis numbered plasma samples performed blind with respect to clinical data.Regional paediatric cardiothoracic unit.Nine patients, median age 4, range 2 9 years, five males. Patients under 1 year were excluded because frequent blood sampling involved.Plasma concentrations atrial natriuretic peptide (ANP), arginine vasopressin, renin activity, aldosterone,...