A5052922610- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Medical Imaging Techniques and Applications
- Noise Effects and Management
- Cardiac Imaging and Diagnostics
- Neural dynamics and brain function
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Vestibular and auditory disorders
- EEG and Brain-Computer Interfaces
- Medical Imaging and Pathology Studies
- Pancreatic and Hepatic Oncology Research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Software Engineering Research
- Infant Development and Preterm Care
- Advanced Malware Detection Techniques
- Radiopharmaceutical Chemistry and Applications
- Parathyroid Disorders and Treatments
- Advanced X-ray and CT Imaging
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Spinal Fractures and Fixation Techniques
- Neuroendocrine Tumor Research Advances
- Spine and Intervertebral Disc Pathology
- Chemokine receptors and signaling
National University of Singapore
2017-2023
Vanderbilt University Medical Center
2005-2021
Center for Autism and Related Disorders
2021
Inserm
2016-2018
Sorbonne Paris Cité
2016-2018
Université Paris Cité
2016-2018
Hôpital Cochin
2016-2018
Oregon Health & Science University
2006-2017
University College London
2015-2017
Centre National de la Recherche Scientifique
2016
Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an excellent target clinical immunosuppression. We report the development a specific, orally active inhibitor JAK3, CP-690,550, that significantly prolonged survival in murine model heart transplantation and cynomolgus monkeys receiving kidney transplants. CP-690,550 treatment was not associated with hypertension, hyperlipidemia, or lymphoproliferative disease. On basis these preclinical results, we...
Auditory brainstem potentials were recorded from scalp electrodes in 42 infants ranging gestational age 25 to 44 weeks. The latencies of the various potential components decreased with maturation. Wave V, evoked by 65-dB sensation level clicks, changed latency 9.9 msec at 26 weeks gestation 6.9 40 gestation. Central conduction times auditory pathway also maturation 7.2 5.2 effects and cochlear disorders on noted several abnormal infants. application all these techniques could permit an...
App Store Analysis studies information about applications obtained from app stores. stores provide a wealth of derived users that would not exist had the been distributed via previous software deployment methods. combines this non-technical with technical to learn trends and behaviours within these forms repositories. Findings have direct actionable impact on teams develop for stores, led techniques requirements engineering, release planning, design, security testing. This survey describes...
Preamble……1 I. Introduction: patient management, licensure.……2 II. Goals.……2 III. Definitions: risk levels……2 IV. Common clinical indications……3 V. Qualifications and responsibilities of personnel (in the United States).……3 VI. Procedure/specifications
Muscle biopsies were obtained from three cyclists and four runners at the end of 10-24 mo intensive training after intervals detraining up to 12 wk. Control samples came untrained persons former athletes. Macro mixed fiber assayed for lactate dehydrogenase, adenylate kinase, glycogen phosphorylase, citrate synthase, malate beta-hydroxyacyl-CoA succinate beta-hydroxybutyrate creatine hexokinase, 1-phosphofructokinase, fructosebisphosphatase, protein, total creatine. In case trained two...
herapy for large prolactinomas remains controversial. Surgery is often unsuccessful in restoring endocrine function to normal. However, medical therapy with bromocriptine, a dopamine agonist, not only suppresses PRL levels, but may also lead reduction tumor size. Previous reports have demonstrated radiographic evidence of regression after 3 or more months bromocriptine therapy. We now documented, the first time, objective extremely rapid size two patients harboring PRL-secreting pituitary...
Objective To compare the first 20 patients who underwent minimally invasive radioguided parathyroidectomies (MIRPs) performed at authors' institution with similar a more conventional surgical approach for primary hyperparathyroidism. Summary Background Data The technique of parathyroidectomy has traditionally involved bilateral exploration neck intent visualizing four parathyroid glands and resecting enlarged glands. Parathyroid scanning using radioisotopes evolved now can localize adenomas...
An inhibitor of human liver glycogen phosphorylase a (HLGPa) has been identified and characterized in vitro vivo. This substance, [R-(R*, S*)]-5-chloro-N-[3-(dimethylamino)-2-hydroxy-3-oxo-1-(phenylmethyl)pr opyl]-1H-indole-2-carboxamide (CP-91149), inhibited HLGPa with an IC50 0.13 microM the presence 7.5 mM glucose. CP-91149 resembles caffeine, known allosteric inhibitor, that it is 5- to 10-fold less potent absence Further analysis, however, suggests caffeine are kinetically distinct....
Answers to questionnaires filled out by 436 patients who visited our tinnitus clinic were analyzed. Patients asked report the presence or absence of depression and rate loudness severity their tinnitus. Responses questions about from 121 reported current compared with responses 285 no history depression. There was significant difference in between without However, scored significantly higher than on all 12 relating severity. We conclude that are linked some patients. Treatment medications...
To investigate similarities between patients who experience chronic tinnitus or pain and to formulate treatment strategies that are likely be effective for phantom auditory pain.A total of 160 rated the severity loudness their completed State-Trait Anxiety Inventory (STAI) an abbreviated version Beck Depression (aBDI). Patients received counseling, audiometric testing, matched sounds played through headphones.A specialized clinic within urban medical center.Tinnitus was highly correlated...
Hearing aids are commonly used for tinnitus management () but there is limited evidence to support their use. The purpose of this study was quantify the effectiveness hearing and counseling as a treatment option. This retrospective analysis handicap questionnaire (THQ, ) results from 58 patients with loss who received counseling, (1) chose follow recommendations aid fitting, or (2) not have aids. groups (N = 29 each) had similar audiometric configuration, duration, age. It hypothesized that...
Many papers on App Store Mining are susceptible to the Sampling Problem, which exists when only a subset of apps studied, resulting in potential sampling bias. We introduce and study its effects sets user review data. investigate bias, techniques for amelioration Analysis, where bias is often unavoidable. mine 106,891 requests from 2,729,103 reviews properties 3 different partitions: with fully complete data, partially no data at all. find that app metrics such as price, rating, download...
App developers would like to understand the impact of their own and competitors' software releases. To address this we introduce Causal Impact Release Analysis for app stores, our tool, CIRA, that implements analysis. We mined 38,858 popular Google Play apps, over a period 12 months. For these identified 26,339 releases which there was adequate prior posterior time series data facilitate causal found 33% caused statistically significant change in user ratings. use approach reveal important...
Many papers on App Store Mining are susceptible to the Sampling Problem, which exists when only a subset of apps studied, resulting in potential sampling bias. We introduce and study its effects sets user review data. investigate bias, techniques for amelioration Analysis, where bias is often unavoidable. mine 106,891 requests from 2,729,103 reviews properties 3 different partitions: with fully complete data, partially no data at all. find that app metrics such as price, rating, download...
Context: App stores provide a software development space and market place that are both different from those to which we have become accustomed for traditional development: The granularity is finer there far greater source of information available research analysis. Information on price, customer rating and, through the data mining approach presented in this paper, features claimed by app developers. These attributes make ideal empirical engineering Objective: This paper1 exploits Store...
Objective To evaluate the results of a large series patients undergoing minimally invasive radioguided parathyroidectomy (MIRP) in which routine use intraoperative parathyroid hormone assay was not used, and to investigate characteristics between who had positive preoperative scans versus those with negative scans. Summary Background Data The technique has traditionally involved bilateral exploration neck under general endotracheal anesthesia. Parathyroid imaging using technetium-99m...