A5040903300- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Photochromic and Fluorescence Chemistry
- Sulfur Compounds in Biology
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Semiconductor Lasers and Optical Devices
- Photoacoustic and Ultrasonic Imaging
- Analytical Chemistry and Sensors
- Supramolecular Self-Assembly in Materials
- Photoreceptor and optogenetics research
- Crystallography and molecular interactions
- Infrared Target Detection Methodologies
- Photonic and Optical Devices
- Polydiacetylene-based materials and applications
- Synthesis and Properties of Aromatic Compounds
- Adsorption and biosorption for pollutant removal
- Chromium effects and bioremediation
- Image Enhancement Techniques
- Gas Sensing Nanomaterials and Sensors
- Nanoparticle-Based Drug Delivery
East China University of Science and Technology
2012-2025
Hebei University of Science and Technology
2024-2025
First Hospital of Shanxi Medical University
2023-2025
Shanxi Medical University
2023-2025
Chery Automobile (China)
2024
Geely (China)
2024
Shanghai Institute of Technology
2024
Hangzhou Dianzi University
2024
Garvan Institute of Medical Research
2021-2023
State Key Laboratory of Bioreactor Engineering
2023
High-fidelity mapping of amyloid-β (Aβ) plaques is critical for the early detection Alzheimer's disease. However, in vivo probing Aβ by commercially available thioflavin derivatives (ThT or ThS) has proven to be extremely limited, as evident restriction enrichment quenching effect, low signal-to-noise (S/N) ratio, and poor blood–brain barrier (BBB) penetrability. Herein, we demonstrate a rational design strategy near-infrared (NIR) aggregation-induced emission (AIE)-active probes plaques,...
Abstract Chemical passivation is an effective approach to suppress the grain surface dominated charge recombination in perovskite solar cells (PSCs). However, effect usually labile on crystal since most passivating agents are weakly anchored. Here, use of a bidentate molecule, 2‐mercaptopyridine (2‐MP), increase anchoring strength for improving efficacy and stability synchronously demonstrated. Compared monodentate counterparts pyridine p ‐toluenethiol, 2‐MP CH 3 NH PbI film results twofold...
We describe an enzyme-regulated liberation strategy to <italic>in situ</italic> generate AIEgen nanoaggregates for on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells.
Abstract The occurrence and transmission of chirality is a fascinating characteristic nature. However, the intermolecular efficiency circularly polarized luminescence (CPL) remains challenging due to poor through‐space energy transfer. We report unique CPL from inducing achiral acceptor emit within specific liquid crystal (LC)‐based system through fluorescence resonance transfer ( C ‐FRET), wherein luminescent cholesteric LC employed as donor, rationally designed long‐wavelength...
Chemiluminescence (CL)-based technologies have revolutionized in vivo monitoring of biomolecules. However, significant technical hurdles limited the achievement trigger-controlled, bright, and enriched CL signal. Herein, a dual-lock strategy uses sequence-dependent triggers for bright optical imaging with real-time fluorescent signal ultra-sensitive These probes can obtain an analyte-triggered accumulation stable pre-chemiluminophore aggregation-induced emission (AIE), then exhibits rapid...
Abstract High‐fidelity trapping of mitochondrial dynamic activity is critical to value cellular functions and forecast disease but lack spatial–temporal probes. Given that commercial mitochondria probes suffering from low photostability, aggregation‐caused quenching effect, limited signal‐to‐noise ratio fluorescence “ always on ” in the process targeting mitochondria, here, rational design strategy a novel aggregation‐induced emission (AIE) molecular motif unique insight into high‐fidelity...
Abstract Fluorescence-based technologies have revolutionized in vivo monitoring of biomolecules. However, significant technical hurdles both probe chemistry and complex cellular environments limited the accuracy quantifying these Herein, we report a generalizable engineering strategy for dual-emission anti-Kasha-active fluorophores, which combine an integrated fluorescein with chromene (IFC) building block donor-π-acceptor structural modification. These fluorophores exhibit invariant...
Leucine aminopeptidase (LAP), one of the important proteolytic enzymes, is intertwined with progress many pathological disorders as a well-defined biomarker. To explore fluorescent probe for quantitative detection LAP distribution and dynamic changes, herein we report LAP-targeting near-infrared (NIR) (DCM-Leu) ratiometric trapping activity in different kinds living cells. DCM-Leu composed NIR-emitting fluorophore (DCM) reporter l-leucine triggered moiety, which are linked together by an...
The strategy of molecularly precise self-assembly theranostic nanoprobes within a single-molecular framework is used to avoid batch-to-batch variability, and concurrently achieving real-time tracking the<italic>in vivo</italic>behaviour prodrugs for the first time.
Abstract Intramolecular charge transfer (ICT) is a fundamental mechanism that enables the development of numerous fluorophores and probes for bioimaging sensing. However, electron-withdrawing targets (EWTs)-induced fluorescence quenching long-standing unsolved issue in ICT fluorophores, significantly limits widespread applicability. Here we report simple generalizable structural-modification completely overturning intramolecular rotation driving energy, thus fully reversing fluorophores’...
Although tumor-infiltrating lymphocytes (TILs) maintain their ability to proliferate, persist, and eradicate tumors, they are frequently dysfunctional in situ. By performing both whole-genome CRISPR metabolic inhibitor screens, we identify that nicotinamide phosphoribosyltransferase (NAMPT) is required for T cell activation. NAMPT low TILs, its expression controlled by the transcriptional factor Tubby (TUB), whose activity depends on receptor-phospholipase C gamma (TCR-PLCγ) signaling axis....
An ongoing revolution in fluorescence-based technologies has transformed the way we visualize and manipulate biological events. enduring goal this field is to explore high-performance fluorogenic scaffolds that show tunability capability for vivo analysis, especially small-molecular near-infrared (NIR) fluorophores. We present a unique bent-to-planar rehybridization design strategy NIR scaffolds, thus yielding palette of switchable bent/planar Si-rhodamines span from visible NIR-II...
Abstract Uniting photothermal therapy (PTT) with magnetic resonance imaging (MRI) holds great potential in nanotheranostics. However, the extensively utilized hydrophobicity‐driven assembling strategy not only restricts intramolecular motion‐induced PTT, but also blocks interactions between MR agents and water. Herein, we report an aggregation‐induced emission luminogen (AIEgen)‐mediated polyelectrolyte nanoassemblies (APN) strategy, which bestows a unique “soft” inner microenvironment good...
ConspectusFluorescent dyes have revolutionized the way we study life science and conduct medical diagnostics. Compared with visible wavelengths, near-infrared (NIR) fluorescence has gained significant attention due to its unique properties, such as deep tissue penetration, reduced autofluorescence, improved signal-to-noise ratios, making it highly desirable for a wide range of in vivo applications including noninvasive sensing, cancer research, drug delivery.In absorption light by...
Protein clustering/disassembling is a fundamental process in biomolecular condensates, playing crucial roles cell fate decision and cellular homeostasis. However, the inherent features of protein clustering, especially for its reversible behavior subtle microenvironment variation, present significant hurdles probe chemistry tracking clustering dynamics. Herein, we report bilateral‐tailored chemigenetic probe, which an "amphiphilic" AIEgen QMSO3Cl covalently conjugated to tag that genetically...
Open AccessCCS ChemistryRESEARCH ARTICLES3 Feb 2025Oxazolidine-Caged Heptamethine Cyanine Switch Exhibits High Photostability for Bioimaging via Buffering Fluorogenicity QingKai Qi, Jin Li, Qinglong Qiao, Chenxu Yan, Mohammad Izadyar, Chao Wang, Syed Ali Abbas Abedi, Xiaogang Liu, Zhiqian Guo and Zhaochao Xu Qi , Li Qiao Yan Izadyar Wang Abedi Liu https://doi.org/10.31635/ccschem.025.202405383 SectionsSupplemental MaterialAboutPDF ToolsAdd to favoritesDownload CitationsTrack Citations...
To investigate the influence of early dysphagia on quality life in patients with partial laryngectomy, and to application value Flexible Endoscopic Evaluation Swallowing (FEES). This study included 30 inpatients who underwent laryngectomy due laryngeal cancer. In postoperative period, a comprehensive assessment was conducted each patient, encompassing Videofluoroscopic Study (VFSS), (FEES), MD Anderson Dysphagia Inventory (MDADI). Each patient two evaluations at different time points...