A5063997413- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Eosinophilic Esophagitis
- Alcohol Consumption and Health Effects
- Mycobacterium research and diagnosis
- Global Cancer Incidence and Screening
- Clinical practice guidelines implementation
- Liver Disease and Transplantation
- Esophageal Cancer Research and Treatment
- Diverticular Disease and Complications
- Potassium and Related Disorders
- Digestive system and related health
- Gastrointestinal disorders and treatments
- IL-33, ST2, and ILC Pathways
- Autoimmune and Inflammatory Disorders Research
- Folate and B Vitamins Research
- Acute Lymphoblastic Leukemia research
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
Glasgow Royal Infirmary
2011-2025
Edinburgh Cancer Research
2023
NHS Greater Glasgow and Clyde
2019-2022
Western Infirmary
2007
University of Glasgow
2007
CS Diagnostics
2003
Mount Sinai Beth Israel
1985
City University of New York
1985
Icahn School of Medicine at Mount Sinai
1985
New York Blood Center
1985
BackgroundUp to 60% of patients with Crohn's disease need intestinal resection within the first 10 years diagnosis, and postoperative recurrence is common. We investigated whether mercaptopurine can prevent or delay clinical disease.MethodsWe did a randomised, placebo-controlled, double-blind trial at 29 UK secondary tertiary hospitals (aged >16 in Scotland >18 England Wales) who had confirmed diagnosis undergone resection. Patients were randomly assigned (1:1) by computer-generated...
The aim of this work was to quantify post-colonoscopy colorectal cancer (PCCRC) rates in National Health Service (NHS) Scotland using World Endoscopy Association guidelines, compare incidence between health boards and referral streams explore comparisons results with published data from other healthcare systems. This is a population-based cohort study NHS 2012 2018. All people undergoing colonoscopy 2018 subsequently diagnosed as having bowel up 3 years after their investigation were...
Summary Background As a non‐invasive marker of gastrointestinal inflammation, faecal calprotectin ( FC ) is being increasingly used to guide the management Crohn's disease. It therefore concern that studies have shown variability in day levels. Aim To determine degree this intrapersonal context quiescent Methods A single‐centre prospective study was undertaken 143 disease patients clinical remission. Three levels were analysed from stool samples on consecutive days. Consistency determined by...
Abstract Background Faecal calprotectin (FC) is a non-invasive marker of gastrointestinal inflammation. Aim To determine whether higher FC levels in individuals with quiescent Crohn's disease are associated clinical relapse over the ensuing 12 months. Methods A single centre prospective study was undertaken patients remission. The receiver operating characteristic (ROC) curve for primary endpoint by months, based on at baseline, calculated. Kaplan–Meier curves time to were resulting optimal...
Abstract Aim Lower gastrointestinal (GI) symptoms are poor predictors of colorectal cancer (CRC). The aim this study was to examine the diagnostic yield colonoscopy by faecal haemoglobin (f‐Hb) concentration in symptomatic patients assessed primary care immunochemical testing (FIT). Method In three Scottish NHS Boards, FIT kits (HM‐JACKarc, Hitachi Chemical Diagnostics Systems Co., Ltd, Tokyo, Japan) were used general practitioners guide referrals for with lower GI (laboratory data studied...
<h3>Background:</h3> The major potential site of acid nitrosation is the proximal stomach, an anatomical prone to a rising incidence metaplasia and adenocarcinoma. Nitrite, pre-carcinogen present in saliva, can be converted nitrosating species <i>N-</i>nitroso compounds by acidification at low gastric pH presence thiocyanate. <h3>Aims:</h3> To assess effect lipid ascorbic on nitrosative chemistry under conditions simulating human stomach. <h3>Methods:</h3> was modelled <i>in vitro</i>...
Background & AimsDNA methylation alterations may provide important insights into gene-environment interaction in cancer, aging, and complex diseases, such as inflammatory bowel disease (IBD). We aim first to determine whether the circulating DNA methylome patients requiring surgery predict Crohn's (CD) recurrence following intestinal resection; second compare seen with established CD that we had reported a series of inception cohorts.MethodsTOPPIC was placebo-controlled, randomized...
Hepatic cirrhosis is infrequently diagnosed in young adults. In a hospital for addictive diseases New York City, we found 53 patients under age 35 within just 40 months. The was biopsy-proven 37 (group I) and clinically 16 with severe liver disease II). Alcohol abuse 51 (96%), parenteral heroin seen 52 (98%). duration of alcohol seven or fewer years 24 (45%) 10 39 (74%). 44 (83%), the substance began adolescence. Comparison group I cirrhotic 65 non-cirrhotic biopsied showed that...
Abstract Purpose Faecal Immunochemical Test (FIT) has proven utility for Colorectal Cancer (CRC) detection in symptomatic patients. Most studies have examined FIT patients subsequently referred from primary care. We investigated associations between CRC and both non-referred Methods A retrospective, observational study of all with a submitted Aug 2018 to Jan 2019 NHS GG&C was performed. Referral colorectal/gastroenterology decision perform colonoscopy were recorded. results grouped as...
Objectives Flexible sigmoidoscopy screening at around age 60 can reduce colorectal cancer incidence. Insufficient evidence exists on flexible in a population being offered biennial faecal occult blood test from 50. This randomized controlled trial assessed if would be an effective adjunct to test. Methods In the Scottish Bowel Screening Programme between June 2014 and December 2015, 51,769 individuals were instead of or continue Those not accepting those with normal All...
Background The faecal immunochemical test (FIT) has proven utility for colorectal cancer detection in symptomatic patients. However, most patients with a raised haemoglobin (f-Hb) do not have cancer. We investigated alternative diagnoses and demographics associated f-Hb Methods A retrospective, observational study was performed of FIT submitted between August 2018 to January 2019 NHS Greater Glasgow Clyde followed by colonoscopy. Colonoscopy/pathology reports were searched diagnoses....
<h3>Introduction</h3> Severe alcoholic hepatitis (AH) is associated with high short term mortality. Although still attracting some controversy, many hospitals will treat severe AH corticosteroids (CS). Early identification of patients not responding to CS treatment crucial as continuing may be side-effects and considered futile. More importantly, non-responders (NR) essential alternative therapies improve their poor survival prognosis. The aim the present study was compare three previously...
<h3>Introduction</h3> Analysis of faecal calprotectin (FC) is a non-invasive method for differentiating IBS from IBD. As screening test, normal FC has been employed to support diagnosis IBS, thereby avoiding invasive endoscopy in the patient cohort. We sought investigate diagnostic yield on subsequent colonoscopy patients with mildly elevated and lower GI symptoms. <h3>Methods</h3> Between November 2009 2010, all value 50–100 μg/g stool (normal <50) were identified our database. All...
<h3>Introduction</h3> There is increasing interest in using Quantitative Faecal Immunochemical Testing (QFIT) for Haemoglobin as a 'rule out' test significant colonic disease symptomatic patients. It has been demonstrated elsewhere Scotland that incorporating faecal haemoglobin testing into primary care clinical assessment tool can safely and effectively prioritise referral colorectal investigation. Here we present results of our own experience the largest Scottish Health board (population...
<h3>Introduction</h3> Intravenous corticosteroids have been established as the mainstay treatment of acute severe colitis since 1974.<sup>1</sup> BSG and ECCO guidelines advise either IV hydrocortisone 100 mg qds or methylprednisolone 30 bd in this setting.<sup>2,3</sup> The potent mineralocorticoid effect however is well known.<sup>4</sup> This could predispose to hypokalaemia susceptible patient cohort. For reason, we recently changed our practice at Glasgow Royal Infirmary (GRI) treat...
<h3>Introduction</h3> Biologics are increasingly used in the management of Crohn’s disease (CD). NICE guidelines advise reassessing CD patients after 12 months treatment with infliximab and discontinuing therapy for stable clinical remission. Evidence suggests that sustained remission may be achieved up to 50–60% these on withdrawal treatment. However, it is recognised decisions regarding continuing must individualised take into account previous behaviour. We sought determine how often...