A5028706827- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Radiopharmaceutical Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Animal Genetics and Reproduction
- Chronic Lymphocytic Leukemia Research
- Virus-based gene therapy research
- RNA and protein synthesis mechanisms
- Childhood Cancer Survivors' Quality of Life
- DNA Repair Mechanisms
- Animal Virus Infections Studies
- Protein Degradation and Inhibitors
- Molecular Biology Techniques and Applications
- Retinoids in leukemia and cellular processes
- Long-Term Effects of COVID-19
- Chromosomal and Genetic Variations
- Cancer-related Molecular Pathways
- Mitochondrial Function and Pathology
- Histone Deacetylase Inhibitors Research
- Cancer therapeutics and mechanisms
- Cancer Treatment and Pharmacology
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- COVID-19 Clinical Research Studies
Sechenov University
2020-2021
Russian Cancer Research Center NN Blokhin
1999-2017
Cancer Research Center
1980-2014
Abstract Background The epidemiology, clinical course, and outcomes of patients with coronavirus disease 2019 (COVID-19) in the Russian population are unknown. Information on differences between laboratory-confirmed clinically diagnosed COVID-19 real-life settings is lacking. Methods We extracted data from medical records adult who were consecutively admitted for suspected infection Moscow 8 April 28 May 2020. Results Of 4261 hospitalized COVID-19, available 3480 (median age, 56 years;...
The effects of cyclophosphamide and three its known metabolites (nitrogen mustard, acrolein, nor-nitrogen mustard on chromosome breakage sister chromatid exchange (SCE) were analyzed in vitro with without the presence a metabolic activating system (liver S9). We confirmed that induced SCE only S9. After metabolism, cyclophosphamde was more active than other agents inducing SCE. Thus, agent(s) directly responsible for this induction high rate not study. On hand, acrolein most toxic to cell...
Difficulties related to the obtainment of stem/progenitor cells from skeletal muscle tissue make search for new sources myogenic highly relevant. Alveolar mucosa might be considered as a perspective candidate due availability and high proliferative capacity its cells. Human alveolar (AMC) were obtained gingival biopsy samples collected 10 healthy donors cultured up passages. AMC matched generally accepted multipotent mesenchymal stromal criteria possess population doubling time, caryotype...
The t(7;12)(q36;p13) translocation is a recurrent chromosome abnormality that involves the ETV6 gene on 12 and has been identified in 20–30% of infant patients with acute myeloid leukaemia (AML). detection t(7;12) rearrangements relies use fluorescence situ hybridization (FISH) because this hardly visible by banding methods. Furthermore, fusion transcript HLXB9-ETV6 found approximately 50% cases, making reverse transcription PCR approach not an ideal screening method. Considering report few...
We have shown previously that two cytoplasmic actin isoforms play different roles in neoplastic cell transformation. Namely, β-cytoplasmic acts as a tumor suppressor, whereas γ-cytoplasmic enhances malignant features of cells. The distinct participation each the cycle driving was also observed. goal this study to describe diverse actins progression chromosomal instability MDA-MB-231 basal-like human carcinoma line. performed traditional methods chromosome visualization, well 3D-IF microscopy...
7 ФГБУ «Федеральный научно-клинический центр детской гема-
The results of treatment children with acute myeloid leukemia (AML) are not satisfied yet. standard chemotherapy allows achieve complete remission in 92–96 % patients, but disease free survival (DFS) and event (EFS) good In a new study – NII DOG AML 2012 the specific aim was to explore effectiveness demethylating drug (Decitabine) inhibitors histon deacetylase (HDAC) find place chemotherapy. From 01.2013 09.2016 26 patients were enrolled into study. average 6.5 ± 1.24 years (6 mo 16 years):...