A5048032320- Stress Responses and Cortisol
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Tryptophan and brain disorders
- Heart Rate Variability and Autonomic Control
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Neuroscience and Music Perception
- Face Recognition and Perception
- Birth, Development, and Health
- Neural dynamics and brain function
- Family Caregiving in Mental Illness
- Child and Adolescent Psychosocial and Emotional Development
- Intergenerational Family Dynamics and Caregiving
- Functional Brain Connectivity Studies
Max Planck Institute of Psychiatry
2021-2024
Goethe University Frankfurt
2021
Abstract Different psychiatric disorders as well exposure to adverse life events have individually been associated with multiple age-related diseases and mortality. Age acceleration in different epigenetic clocks can serve biomarker for such risk could help disentangle the interplay of comorbidity early adversity on We evaluated five (Horvath, Hannum, PhenoAge, GrimAge DunedinPoAm) a transdiagnostic sample using epigenome-wide DNA methylation data from peripheral blood 429 subjects two...
Abstract Major depressive disorder (MDD) has been related to abnormal amygdala activity during emotional face processing. However, a recent large-scale study ( n = 28,638) found no such correlation, which is probably due the low precision of fMRI measurements. To address this issue, we used simultaneous and eye-tracking measurements commonly employed recognition task. Eye-tracking provide high-precision data, can be enrich potentially stabilize readouts. With behavioral response,...
Abstract In a subset of patients with mental disorders, such as depression, low-grade inflammation and altered immune marker concentrations are observed. However, these alterations often assessed by only one data type small panels. Here, we used transdiagnostic approach combined from two cohorts to define subgroups depression symptoms across the diagnostic spectrum through large-scale multi-omics clustering in 237 individuals. The method incorporated age, body mass index (BMI), 43 plasma...
Research on visual working memory has shown that individual stimulus features are processed in both specialized sensory regions and higher cortical areas. Much less evidence exists for auditory memory. Here, a main distinction been proposed between the processing of spatial non-spatial sound features. Our aim was to examine feature-specific activation patterns memory.We collected fMRI data while 28 healthy adults performed an delayed match-to-sample task. Stimuli were abstract sounds...
Abstract Abnormalities in the neural mechanisms of stress response have potential to serve as a transdiagnostic marker for stress-related disorders. This is rooted highly individual and dynamic response, which poses challenge classical experimentally informed models that focus on specific phases, conditions, or stimuli during task. Here, we integrate heart rates (HR) an immanent index stress-response combine these with functional magnetic resonance imaging (fMRI) data. In this study, 83...