A5046834534- Urinary Bladder and Prostate Research
- Neuroscience and Neuropharmacology Research
- Estrogen and related hormone effects
- Urinary Tract Infections Management
- Pharmacogenetics and Drug Metabolism
- Pelvic floor disorders treatments
- Computational Drug Discovery Methods
- Drug-Induced Hepatotoxicity and Protection
- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Inflammatory mediators and NSAID effects
- Bee Products Chemical Analysis
- HIV/AIDS drug development and treatment
- Pharmacological Receptor Mechanisms and Effects
- Liver physiology and pathology
- HIV Research and Treatment
- Animal testing and alternatives
- Genetics and Neurodevelopmental Disorders
- Glutathione Transferases and Polymorphisms
- Biosimilars and Bioanalytical Methods
- Genomics and Rare Diseases
- Analytical Methods in Pharmaceuticals
- Genomic variations and chromosomal abnormalities
- Genomics, phytochemicals, and oxidative stress
- Urinary and Genital Oncology Studies
Pfizer (Japan)
2007-2020
Japan Medical Association
2013-2015
Pfizer (United States)
2006-2010
Nagoya University
2007
Kyoto University
1994
The objective of this study was to elucidate the range abilities nonclinical safety assessment for predicting adverse drug reactions (ADRs) in humans. dataset included 1256 ADRs with an incidence rate 5% or more collected from 142 drugs approved Japan 2001 2010 (excluding anticancer agents and vaccines). Gastrointestinal, neurological hepatobiliary were relatively common, followed by hematological, cutaneous, systemic cardiovascular dataset. analysis revealed that 48% predictable based on a...
N-methyl-D-aspartate receptors play an important role in nociceptive transmissions various types of pain. In this study, we investigated the pain-related response mice lacking N-methyl-D-aspartate-type glutamate receptor epsilon1 or epsilon4 subunit formalin test and partial sciatic nerve ligation-induced neuropathic pain model. The second tonic inflammatory phase was significantly reduced knockout epsilon1(-/-) mice, but not epsilon4(-/-) when compared with wild-type mice. ligation model,...
In this survey, the correlation between adverse drug reactions (ADRs) in human and animal toxicities was investigated for 393 medicines which were approved Japan from September 1999 to March 2013. ADRs collected each Japanese package insert. Comparable with by thorough investigation of common technical documents. The results survey show that hypertension and/or hypotension mainly observed affecting central nervous system. Hypertension also antipyretics, analgesics, anti-inflammatory agents,...
Abstract Objectives To examine the effect of combining a nonselective muscarinic receptor antagonist, 5‐hydroxymethyl tolterodine (an active metabolite fesoterodine), with β3 adrenoceptor agonist, mirabegron, in rat model pelvic congestion. Methods The congestion used female Sprague‐Dawley rats their bilateral common iliac and uterine veins ligated. Expressions M2 M3 subtypes urothelium detrusor were detected by real‐time polymerase chain reaction assays. effects both drugs investigated on...
社会的背景や現在の治療薬の状況から，精神神経疾患に対する治療薬のメディカルニーズは高いが，これらの薬剤が開発途上で中止に至る割合は，他の疾患と比較して依然として高い．開発の成功のためには，創薬標的が薬として疾患に対する正しい標的かどうか（right target），開発候補品が標的に相応する最適の分子・化合物かどうか（right molecule），臨床試験において治療対象となる患者の正しい選択がなされているかどうか（right patient）が重要となる．これらに関して，精神神経疾患では疾患の場となる脳の高次性・複雑さゆえ動物での疾患モデルを用いた検討には限界があり，ヒトでの遺伝学的解析と病因に関する生物学的検討に基づいた創薬を展開する必要がある．本稿では，ヒトでの遺伝学的解析と生物学的検討に基づいた創薬について，30年にわたるアルツハイマー型認知症に関する研究で得られた知見をもとに，創薬開発の根拠としてのアミロイドβ仮説とそれに基づく開発について述べる．さらに，パーキンソン病治療薬の例として，創薬標的の一つであるleucin-rich repeat kinase...
ラット肝サイトソル, およびそれから精製した5種類のグルタチオンS-トランスフェラーゼによるフェニトロチオンの脱メチル化では, 生じたデスメチルフェニトロチオンはいずれの場合も (S)P-(-) 体が (R)P-(+) 体よりも多量であった. マウス肝サイトソルでは (R)p-(+) 体の生成が優勢であった. (+) 体のデスメチルフェニトロチオンのブルシン塩についてX線結晶解析を行ない, これが (R)P-体であることを決定した.