A5055917432- Gut microbiota and health
- Food Security and Health in Diverse Populations
- Diet and metabolism studies
- Nutritional Studies and Diet
- Evolution and Genetic Dynamics
- Clostridium difficile and Clostridium perfringens research
- Parasite Biology and Host Interactions
- Earthquake Detection and Analysis
- Helminth infection and control
- Geophysics and Gravity Measurements
- Ionosphere and magnetosphere dynamics
- Plant and animal studies
- Animal Behavior and Reproduction
- Genomics and Phylogenetic Studies
- Genetics, Bioinformatics, and Biomedical Research
- Genetic diversity and population structure
- Mollusks and Parasites Studies
- Dietary Effects on Health
- Adipokines, Inflammation, and Metabolic Diseases
- Aquatic Invertebrate Ecology and Behavior
- Probiotics and Fermented Foods
- Plant Reproductive Biology
- Diverse Music Education Insights
- Educational methodologies and cognitive development
- RNA and protein synthesis mechanisms
Vidarium - Centro de Investigación en Nutrición Salud y Bienestar
2014-2024
Fundación Con Vida
2014-2024
Universidad El Bosque
2024
Pacific Northwest National Laboratory
2023
Universidad de Antioquia
2001-2020
Universidad Nacional Autónoma de México
2020
Vidant Health
2020
Centre d'Écologie Fonctionnelle et Évolutive
2007-2015
University of Toronto
2012-2013
Virginia Tech
2012
OBJECTIVE Recent studies suggest the beneficial effects of metformin on glucose metabolism may be microbially mediated. We examined association type 2 diabetes, metformin, and gut microbiota in community-dwelling Colombian adults. On basis previous research, we hypothesized that is associated with higher levels short-chain fatty acid (SCFA)–producing mucin-degrading microbiota. RESEARCH DESIGN AND METHODS Participants were selected from a larger cohort 459 participants. The present analyses...
Fiber fermentation by gut microbiota yields short-chain fatty acids (SCFAs) that are either absorbed the or excreted in feces. Studies conflicting as to whether SCFAs beneficial detrimental cardiometabolic health, and how associated with is unclear. In this study of 441 community-dwelling adults, we examined associations fecal SCFAs, diversity composition, permeability, outcomes, including obesity hypertension. We assessed 16S rRNA gene sequencing, SCFA concentrations gas chromatography/mass...
Stephen Wright, Detlef Weigel and colleagues report the whole-genome sequence of Capsella rubella, a highly selfing crucifer found throughout much southern western Europe. They compare mixed-stage flower bud transcriptomes from C. rubella grandiflora, finding shift in expression genes associated with flowering phenotypes providing insights into transition to selfing. The outcrossing is common plants1,2, but genomic consequences speed at which they emerge remain poorly understood. An...
Microorganisms in the human gut play a role health and disease, adults higher biodiversity has been linked to better health. Since microorganisms may be pivotal development of microbial therapies, understanding factors that shape is utmost interest. We performed large-scale analyses relationship age sex bacterial diversity adult cohorts from four geographic regions: United States, Kingdom, Colombia, China. In U.S., U.K., Colombian cohorts, correlated positively with young but plateaued at...
The composition of the gut microbiota has recently been associated with health and disease, particularly obesity. Some studies suggested a higher proportion Firmicutes lower Bacteroidetes in obese compared to lean people; others found discordant patterns. Most studies, however, focused on Americans or Europeans, giving limited picture microbiome. To determine generality previous observations expand our knowledge human microbiota, it is important replicate overlooked populations. Thus, we...
Lymnaeidae snails play a prominent role in the transmission of helminths, mainly trematodes medical and veterinary importance (e.g., Fasciola liver flukes). As this family exhibits great diversity shell morphology but extremely homogeneous anatomical traits, systematics has long been controversial. Using most complete dataset to date, we examined phylogenetic relationships among 50 taxa using supermatrix approach (concatenation 16 S, ITS-1 ITS-2 genes, representing 5054 base pairs) involving...
In hermaphrodites, traits that influence the selfing rate can coevolve with inbreeding depression, leading to emergence of evolutionary syndromes. Theory predicts a negative correlation between depression and across species. This prediction has only been examined validated in vascular plants. Furthermore, rates are often influenced by environmental conditions (e.g., lack mates or pollinators), species predicted evolve mechanisms buffer this variation. We extend previous studies mating-system...
Westernization and its accompanying epidemiological transitions are associated with changes in gut microbiota. While the extremes of this lifestyle spectrum have been compared (hunter-gatherers, industrialized countries), populations undergoing such shifts received little attention. To fill gap knowledge about microbiome evolution following broad emergence disease-associated dysbiosis, we performed a cross-sectional study which characterized microbiota 441 Colombian adults through 16S rRNA...
Up to 30% of individuals with obesity may exhibit normal insulin sensitivity, a favorable lipid profile, and no signs hypertension. This prompts the exploration factors distinguishing cardiometabolically healthy from those developing complications. cross-sectional study included 116 categorized into four groups by combining abdominal cardiometabolic health statuses. We compared circulating adipokines gut microbiota composition between these groups. Individuals had higher levels hs-CRP,...
Understanding how parental distance affects offspring fitness, i.e., the effects of inbreeding and outbreeding in natural populations, is a major goal evolutionary biology. While often associated with fitness reduction (inbreeding depression), interpopulation outcrossing may have either positive (heterosis) or negative (outbreeding depression) effects. Within metapopulation, all phenomena occur various intensities depending on focal population (especially its effective size) trait studied....
Base composition varies among and within eukaryote genomes. Although mutational bias selection have initially been invoked, more recently GC-biased gene conversion (gBGC) has proposed to play a central role in shaping nucleotide landscapes, especially yeast, mammals, birds. gBGC is kind of meiotic drive favor G C alleles, associated with recombination. Previous studies also suggested that could be at work grass However, these were carried on third codon positions can undergo usage. As most...
Introgressive events (e.g., hybridization, gene flow, horizontal transfer) and incomplete lineage sorting of ancestral polymorphisms are a challenge for phylogenetic analyses since different genes may exhibit conflicting genealogical histories. Grasses the Triticeae tribe provide particularly striking example incongruence among trees. Previous phylogenies, mostly inferred with one gene, in conflict several taxon positions. Therefore, obtaining resolved picture relationships genera species...
Because mating systems affect population genetics and ecology, they are expected to impact the molecular evolution of species. Self-fertilizing species experience reduced effective size, recombination rates, heterozygosity, which in turn should decrease efficacy natural selection, both adaptive purifying, strength meiotic drive processes such as GC-biased gene conversion. The empirical evidence is only partly congruent with these predictions, depending on analyzed species, some, but not all,...
are abundant in the human gut and comprise families associated with host health such as
Self-fertilization is hypothesized to be an evolutionary dead end because reversion outcrossing can rarely happen, and selfing lineages are thought rapidly become extinct of limited potential for adaptation and/or accumulation deleterious mutations. We tested these two assumptions by combining morphological characters molecular-evolution analyses in a tribe hermaphroditic grasses (Triticeae). First, we determined the mating system 19 studied species. Then, sequenced 27 protein-coding loci...
Ribosomal DNA (rDNA) is one of the most conserved genes in eukaryotes. The multiples copies rDNA genome evolve a concerted manner, through unequal crossing over and/or gene conversion, two mechanisms related to homologous recombination. Recombination increases local GC content several organisms process known as GC-biased conversion (gBGC). gBGC has been well characterized mammals, birds, and grasses, but its phylogenetic distribution across tree life poorly understood. Here, we test...
Abstract Population genetic studies are efficient for inferring the invasion history based on a comparison of native and invasive populations, especially when conducted at species scale. An expected outcome in populations is variability loss, this true self‐fertilizing species. We here focus Pseudosuccinea columella , an hermaphroditic freshwater snail that has greatly expanded its geographic distribution acts as intermediate host Fasciola hepatica causative agent human veterinary...
Chlorogenic acids (CGA) are the most abundant phenolic compounds in green coffee beans and human diet have been suggested to mitigate several cardiometabolic risk factors. Here, we aimed evaluate effect of a water-based standardized extract (GCE) on parameters ApoE-/- mice explore potential underlying mechanisms. Mice were fed an atherogenic without (vehicle) or with GCE by gavage (equivalent 220 mg/kg CGA) for 14 weeks. We assessed metabolic, pathological, inflammatory inferred gut...
Diet plays an important role in shaping gut microbiota. However, much remains to be learned regarding this association. We analyzed dietary intake and microbiota a community-dwelling cohort of 441 Colombians. quality, food groups nutrient consumption were paired with microbial diversity composition using linear regressions, Procrustes analyses random-forest machine-learning algorithm. Analyses adjusted for potential confounders, including the five cities from where participants originated,...
Selfing species experience reduced effective recombination rates and population size, which can lead to reductions in polymorphism the efficacy of natural selection. Here, we use illumina transcriptome sequencing resequencing test for changes polymorphism, base composition, selection selfing angiosperm Collinsia rattanii (Plantaginaceae) compared with its more outcrossing sister linearis. Coalescent analysis indicates intermediate divergence (500,000–1 million years) no ongoing gene flow,...