A5053333742- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury Research
- Multiple Sclerosis Research Studies
- Cervical and Thoracic Myelopathy
- Immune Response and Inflammation
- Cell death mechanisms and regulation
- Muscle Physiology and Disorders
- Cellular transport and secretion
- Long-Term Effects of COVID-19
- Functional Brain Connectivity Studies
- DNA Repair Mechanisms
- Spinal Cord Injury Research
- Cytomegalovirus and herpesvirus research
- Traumatic Brain Injury and Neurovascular Disturbances
- Chronic Lymphocytic Leukemia Research
- Spine and Intervertebral Disc Pathology
- Neonatal and fetal brain pathology
- Immunodeficiency and Autoimmune Disorders
- Genetic factors in colorectal cancer
- Congenital heart defects research
- Neuroinflammation and Neurodegeneration Mechanisms
- NF-κB Signaling Pathways
- BRCA gene mutations in cancer
- Neurogenesis and neuroplasticity mechanisms
University of California, San Francisco
2012-2024
National Human Genome Research Institute
2008
National Institutes of Health
2008
University of Maryland, Baltimore
2006
A male infant developed generalized rash, intestinal inflammation and severe infections including persistent cytomegalovirus. Family history was negative, T cell receptor excision circles were normal, engraftment of maternal cells absent. No defects found in multiple genes associated with combined immunodeficiency. 9/10 HLA matched unrelated hematopoietic transplant (HCT) led to mixed chimerism clinical resolution. We sought an underlying cause for this patient's immune deficiency...
Objective A major challenge in multiple sclerosis (MS) research is the understanding of silent progression and Progressive MS. Using a novel method to accurately capture upper cervical cord area from legacy brain MRI scans we aimed study role spinal atrophy for conversion secondary progressive disease (SPMS). Methods From single‐center observational study, all RRMS (n = 360) SPMS 47) patients 80 matched controls were evaluated. patient subsets who converted 54) or silently progressed 159),...
Abstract Purpose Severe combined immunodeficiency (SCID) is characterized by failure of T lymphocyte development and absent or very low cell receptor excision circles (TRECs), DNA byproducts maturation. Newborn screening for TRECs to identify SCID now performed in several states using PCR from universally collected dried blood spots (DBS). In addition infants with typical SCID, TREC identifies lymphocytopenia who appear healthy whom a diagnosis cannot be confirmed. Deep sequencing was...
MR imaging is essential for MS diagnosis and management, yet it has limitations in assessing axonal damage remyelination. Gadolinium-based contrast agents add value by pinpointing acute inflammation blood-brain barrier leakage, but with drawbacks safety cost. Neurite orientation dispersion density (NODDI) assesses microstructural features of neurites contributing to diffusion signals. This approach may resolve the components pathology, overcoming conventional limitations. Twenty-one subjects...
Concussion, or mild traumatic brain injury (mTBI), is a major public health concern, linked with persistent post-concussive syndrome and chronic encephalopathy. At present, standard clinical imaging fails to reliably detect axonal associated concussion symptoms. Diffusion tensor (DTI) an MR technique that sensitive changes in white matter microstructure. Prior studies using DTI did not jointly investigate microstructure athletes, population at high risk for concussive subconcussive head...
Injuries and illnesses can alter the normal bilateral symmetry of brain, determining extent this disruption may be useful in characterizing pathology. One way quantifying brain is terms correlation diffusion tensor metrics between homologous white matter tracts. With approach, we hypothesized that brains patients with a concussion are more asymmetrical than those healthy individuals without history concussion. We scanned 35 15 emergency department recent Fractional anisotropy (FA), mean...
Abstract Background and Purpose Spinal cord (SC) cross‐sectional areas (CSAs) assessed with MRI have proven to be extremely valuable imaging markers in several diseases. Among the challenges is delineation of vertebral levels determine level‐dependent changes atrophy. With this study, we aimed (1) test hypothesis that there proportionality position first six intervertebral discs length upper portion SC (2) show a approach can simplify CSA assessment across vertebrae offering good...