A5103121732- Marine Sponges and Natural Products
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cardiac Ischemia and Reperfusion
- Acute Ischemic Stroke Management
- Marine Toxins and Detection Methods
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
- Stroke Rehabilitation and Recovery
- Heat shock proteins research
- Asymmetric Synthesis and Catalysis
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Cardiac Fibrosis and Remodeling
- Natural Compounds in Disease Treatment
- Cell death mechanisms and regulation
- Gastrointestinal motility and disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Chemical Synthesis and Analysis
- Thermal Regulation in Medicine
- Redox biology and oxidative stress
- COVID-19 Impact on Reproduction
- Semantic Web and Ontologies
Dalian Maternal and Child Health Hospital
2025
Neijiang Normal University
2024
Guangxi University of Science and Technology
2021
Guangxi Normal University
2019-2021
China Medical University
2018-2021
The Affiliated Yongchuan Hospital of Chongqing Medical University
2019-2021
Chongqing Medical University
2019-2021
The First People's Hospital of Changde
2021
Second Military Medical University
2019
Shanghai Changzheng Hospital
2019
Previous studies showed that Toll-like receptor 4 (TLR4) modulates the myocardial inflammatory response to ischemia-reperfusion injury, and we recently found cytokines link TLR4 postischemic cardiac dysfunction. Although can be activated in cultured cells by endogenous agents including heat shock protein 70, how it is during unknown. In present study, examined 1) whether cognate 70 (HSC70), which constitutively expressed myocardium, released ischemia-reperfusion; 2) extracellular HSC70...
Cardiac surgery with global myocardial ischemia-reperfusion (I/R) induces a inflammatory response that impairs cardiac recovery. Chemokines contribute to the overall through inducing leukocyte infiltration. Although Toll-like receptor 4 (TLR4) has an important role in postischemic injury, relative roles of tissue and TLR4 infiltration, as well chemokine expression, are unclear. Our recent study, isolated mouse heart model I/R, found 70-kDa heat shock cognate protein (HSC70) is released from...
An efficient one-pot synthesis of polysubstituted pyrrolizines from N-vinyl-α,β-unsaturated nitrones and activated alkynes through iron(III)/copper(II)-cocatalyzed [3 + 2] cycloaddition/[3,3]-rearrangement sequential N–O bond cleavage was developed. The reaction first underwent cycloaddition [3,3]-rearrangement to afford nine-membered N-heterocycles, then a controlled rings by iron(III)/copper(II) cocatalysts delivered pyrrolizine scaffolds. A kinetic resolution ring compounds achieved for...
Prenatal anxiety is one of the most prevalent mental disorders during pregnancy. This study assessed prevalence prenatal and examined whether resilience could play mediating role in association between self-efficacy symptoms among pregnant women China.A nationwide smartphone cross-sectional was carried out three cities (Shenyang Liaoning Province, Zhengzhou Henan Province Chongqing Municipality) China from July 2018 to 2019. The questionnaire consisted questions on demographic...
Primary cardiac tumors are extremely rare, with fibromas being one of the more prevalent type primary in infants and children. Cardiac present a high risk fatal arrhythmia sudden death, hence aggressive surgical treatment approaches typically employed. However, certain populations, such as asymptomatic young children early stages, require extra caution. We case patient giant fibroma heart detected during fetal development, who was followed up until age 5 months before undergoing resection....
As a causative agent of food poisonings, azaspiracid (1), novel marine toxin isolated from the mussel Mytilus edulis, challenges synthetic chemist with an intricate array acetal and ketal structures. The construction FGHI ring system was achieved by means key BF3⋅Et2O-catalyzed cyclization to form HI spirocycle. A final chemoselective intramolecular ketalization Hg(OAc)2 formed G ring, afford N-protected as single diastereomer.
Poststroke pneumonia (PSP) is a common complication of stroke and an important cause death following stroke. However, the treatment PSP remains inadequate due to severe impairment respiratory system by PSP. Thus, it crucial focus on preventing improve prognosis patients with stroke.This prospective single-center Cohort study aimed investigate risk factors for pulmonary infection ischemic identify whether significantly influences after stroke.Altogether, 451 who were treated acute in First...
Although visceral hypersensitivity is a major pathophysiological feature of irritable bowel syndrome (IBS), its molecular mechanisms are still poorly understood. c-fos well-established marker cell activation. Accumulating evidence demonstrates that norepinephrine (NE) system dysregulated in IBS; however, very little known on mechanism. It our hypothesis elevated expression central nervous (CNS) correlates with rat model IBS. Furthermore, we explored the changes NE IBS patients. The was...
Background: Cerebral small vessel disease (SVD) is generally considered as a cause of stroke, disability, gait disturbances, vascular cognitive impairment, and dementia. The aim this study was to investigate whether the total SVD burden can be used predict functional outcome in patients with acute ischemic stroke. Methods: From April 2017 January 2018, consecutive stroke who underwent baseline MRI scan were evaluated. assessed using modified Rankin Scale (mRS) at 90 days defined i) excellent...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Concise Total Synthesis of TriptolideDan Yang, Xiang-Yang Ye, Ming Xu, Kwan-Wah Pang, Ning Zou, and Roy M. LetcherView Author Information Department Chemistry, The University Hong Kong, Pokfulam Road, Kong Cite this: J. Org. Chem. 1998, 63, 19, 6446–6447Publication Date (Web):September 1, 1998Publication History Received14 July 1998Published online1 September inissue 1 1998https://doi.org/10.1021/jo981362gCopyright © 1998 American Chemical...
It is generally accepted that insulin exerts an antiapoptotic effect against ischemia/reperfusion through the activation of PI3K/Akt/mTOR pathway. MicroRNAs involve in multiple cardiac pathophysiological processes, including ischemia/reperfusion–induced injury. However, regulation microRNAs cardioprotective rarely discussed. In this study, using a cell model ischemia culturing H9C2 myocytes serum‐free medium with hypoxia, we demonstrated pretreatment significantly inhibited apoptosis and...
The design and synthesis of a new series potent non-prostanoid IP receptor agonists that showed oral efficacy in the rat monocrotaline model pulmonary arterial hypertension (PAH) are described. Detailed profiling number analogues resulted identification 5c (ralinepag) has good selectivity both binding functional assays with respect to most members prostanoid family more modest 30- 50-fold over EP3 receptor. In our hands, its potency comparable or superior MRE269 (the active metabolite...
Comprehensive Summary We described a Yb(OTf) 3 combined with Pybox ligand catalyzed asymmetric [3+3] cycloaddition of N ‐vinyl cinnamaldehyde nitrones activated cyclopropanes to prepare various functionalized 1,2‐oxazines in 24%—95% yields and 22%—96% ee. Experimental results revealed that the reaction underwent domino cycloaddition, dealkenylation, aza‐1,4‐addition three steps. The chiral 1,2‐oxazine could be obtained gram scales easily converted into scaffolds. present method features...
Lebensmittelvergiftungen verursacht Azaspiracid 1, ein kürzlich aus der Miesmuschel Mytilus edulis isoliertes Toxin, doch Wirkmechanismus ist noch unklar. Grund genug, 1 für biologische Untersuchungen durch chemische Synthese zur Verfügung zu stellen. Vorgestellt wird diastereoselektive Aufbau FGHI-Einheit; dabei wurde HI-Spirocyclus BF3⋅Et2O-katalysierten Ringschluss erhalten und G-Ring Ketalisierung mittels Hg(OAc)2.