A5063670195- Cancer survivorship and care
- Radiation Dose and Imaging
- SARS-CoV-2 and COVID-19 Research
- Palliative Care and End-of-Life Issues
- COVID-19 Clinical Research Studies
- Childhood Cancer Survivors' Quality of Life
- Advanced X-ray and CT Imaging
- Electrical and Bioimpedance Tomography
- Pelvic and Acetabular Injuries
- Neuroscience of respiration and sleep
- COVID-19 epidemiological studies
- Viral Infections and Vectors
- Advanced Radiotherapy Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Neutropenia and Cancer Infections
- SARS-CoV-2 detection and testing
- Photoacoustic and Ultrasonic Imaging
- Child Nutrition and Feeding Issues
- Respiratory viral infections research
- Radiation Therapy and Dosimetry
- Health and Wellbeing Research
- Immune responses and vaccinations
- Spinal Fractures and Fixation Techniques
- Traditional Chinese Medicine Studies
- Vaccine Coverage and Hesitancy
SickKids Foundation
2025
Hospital for Sick Children
2023-2025
University of Washington
2025
Reed College
2021-2023
University Health Network
2023
California University of Pennsylvania
2021
Massachusetts General Hospital
2020
Sunnybrook Health Science Centre
2017-2019
Health Sciences Centre
2018-2019
Response Biomedical (Canada)
2017
Spectral CT has been increasingly implemented clinically for its better characterization and quantification of materials through multi-energy results. It also facilitates calculation physical density, allowing non-invasive mass measurements temperature evaluations by manipulating the definition density thermal volumetric expansion, respectively. To develop spectral quantifications, original parametrized Alvarez-Macovski model electron density-physical were validated with a phantom. The best...
Abstract Background High homology and potential cross-reactive immune responses between SARS-CoV-2 seasonal human coronaviruses (HCoVs) have been described by several studies. However, the role of pre-existing immunity to HCoVs in outcome infection vaccination is still unclear. Anti-spike IgG titers against coronavirus (HCoV)-229E, -HKU1, -NL63, -OC43 age participants N=1,675 serum samples were collected from aged 2 95 years (median 44). anti-spike HCoV-229E, quantified...
ABSTRACT A major challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of disease 2019 (COVID-19), has been assessing intensity, dynamics, and determinants antibody responses after infection and/or vaccination. Therefore, we aimed to characterize longitudinal dynamics among naturally infected individuals who achieved hybrid immunity in a large Canadian cohort. We demonstrate that anti-Spike IgGs neutralizing vary greatly COVID-19, peak levels, rate...
Growing evidence suggests that the pathogenesis of type 2 diabetes (T2D) involves dysfunctional central mechanisms, and, hence, brain can be targeted to treat this disease. As an example, a single intracerebroventricular (icv) injection fibroblast growth factor 1 (FGF1) normalize hyperglycemia for weeks or months in rodent models T2D. Convergent implicates inhibition particular subset neurons as mediator FGF1 effect. Specifically, AgRP neurons, which are located hypothalamic arcuate nucleus...
In addition to sustained glucose lowering, centrally administered fibroblast growth factor 1 (FGF1) induces a potent but transient anorexia in animal models of type 2 diabetes. To investigate the mechanism(s) underlying this anorexic response, current work focused on specific neuronal subset located external lateral subdivision parabrachial nucleus marked by expression calcitonin gene-related peptide (elPBNCGRP neurons). These neurons can be activated withdrawal upstream GABAergic inhibitory...
More than 70% of patients with advanced cancer experience dyspnea. Dyspnea is predictive shorter survival and interferes quality life (QOL). The present study aimed to identify predictors the presence severity dyspnea in patients.A prospective database collected from attending a palliative radiotherapy clinic was analyzed for patient demographics, Edmonton Symptom Assessment System (ESAS) scores, Patient-Reported Functional Status (PRFS), history smoking respiratory conditions, pulse...
Background: Cancer patients often present with several concurrent symptoms. There is evidence to suggest that related symptoms can cluster together in stable groups. The study sought identify symptom clusters advanced cancer using the Edmonton Symptom Assessment System (ESAS) a palliative outpatient radiotherapy clinic. Methods: Principal component analysis (PCA), exploratory factor (EFA), and hierarchical (HCA) were used among 9 ESAS items scores from each patient's first visit. Results:...
Physical density assessments may provide valuable insights for a range of diagnostic purposes in abdominal, pulmonary, and breast imaging. These include differentiating iso-attenuating cysts from lesions, aiding function tests viral pneumonia, quantifying cancer risk. also natural intuitive measurement human tissue that be useful measuring global body mass distributions comparing techniques. In this work, we present spectral physical map generated clinical dual-energy computed tomography...
Abstract Spectral CT has been increasingly implemented clinically for its better characterization and quantification of materials through multi-energy results. It also facilitates calculation physical density utilizing the Alvarez-Macovski model without approximations. These spectral quantifications allow non-invasive mass measurements temperature evaluations by manipulating definition thermal volumetric expansion, respectively. To develop model, original parametrized versions electron...
Abstract Background Black North American communities have been disproportionately affected by COVID-19. These data largely based on case counts, hospitalizations and mortality data. Serologic testing enables a more complete determination of infection burden documenting in persons with symptomatic as well asymptomatic infection. We used serologic to determine the extent which SARS-CoV-2 had penetrated into community. examined risk factors associated seropositivity, including presence medical...
Abstract Background Seroprevalence data provide useful information on COVID-19 burden among various communities by detecting infection in both symptomatic and asymptomatic persons. One challenge is the extent to which potential participants agree blood testing. To address this, we conducted a community-based survey assess rates within church congregations understand prevalence closed group setting contrast conventional open community setting. Methods A cross-sectional was consisting of...