A5054027503- Acute Kidney Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Emergency and Acute Care Studies
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Cardiac Arrest and Resuscitation
- Long-Term Effects of COVID-19
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Enhanced Recovery After Surgery
- Blood Pressure and Hypertension Studies
- Aortic aneurysm repair treatments
- Renal and Vascular Pathologies
- Cerebrovascular and Carotid Artery Diseases
- Patient Safety and Medication Errors
- Trauma and Emergency Care Studies
- Muscle and Compartmental Disorders
- Frailty in Older Adults
- Clinical Reasoning and Diagnostic Skills
Karolinska Institutet
2016-2025
Karolinska University Hospital
2015-2025
Mater Misericordiae University Hospital
2024
European Society of Anaesthesiology
2024
Skåne University Hospital
2020
Austin Hospital
2016
Lund University
2015
National Patient Safety Foundation
2006
University Hospital Heidelberg
2006
Stanford University
2006
Acute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely provide benefit. Identifying early markers damage has been difficult due the complex nature human AKI, in which multiple etiologies exist. The objective this study was identify validate novel biomarkers AKI.
<h3>Importance</h3> In the last decade, new biomarkers for acute kidney injury (AKI) have been identified and studied in clinical trials. Guidance is needed regarding how best to incorporate them into practice. <h3>Objective</h3> To develop recommendations on AKI based existing data expert consensus practicing clinicians researchers. <h3>Evidence Review</h3> At 23rd Acute Disease Quality Initiative meeting, a meeting of 23 international experts critical care, nephrology, related specialties,...
<h3>Importance</h3> Small studies and anecdotal evidence suggest marked differences in the use of opioids after surgery internationally; however, this has not been evaluated systematically across populations receiving similar procedures different countries. <h3>Objective</h3> To determine whether there are frequency, amount, type dispensed among United States, Canada, Sweden. <h3>Design, Setting, Participants</h3> This cohort study included patients without previous opioid prescriptions aged...
Background. We wished to determine the optimal duration of follow-up for patients with acute renal failure (ARF) treated continuous replacement therapy (CRRT) and tested hypothesis that a 6 month would be minimum catch most mortalities. In addition, we evaluated association between mortality RIFLE classification in same patients.
Surgical audit, sometimes including public reporting, is an important foundation of high quality health care. We aimed to assess the validity a novel outcome metric, days at home up 30 after surgery, as surgical measure in clinical trials and assurance.This was multicentre, registry-based cohort study. used prospectively collected hospital national healthcare registry data obtained from patients aged 18 years or older undergoing broad range surgeries Sweden over 10-year period. The...
The immunopathology of coronavirus disease 2019 (COVID-19) remains enigmatic, causing immunodysregulation and T cell lymphopenia. Monocytic myeloid-derived suppressor cells (M-MDSCs) are suppressors that expand in inflammatory conditions, but their role acute respiratory infections unclear. We studied the blood airways patients with COVID-19 across severities at multiple time points. M-MDSC frequencies were elevated not nasopharyngeal or endotracheal aspirates compared healthy controls....
Acute Kidney Injury (AKI) is common in critical ill populations and its association with high short-term mortality well established. However, long-term risks of death renal dysfunction are poorly understood few studies exclude patients pre-existing disease, meaning outcome for de novo AKI has been difficult to elicit. We aimed compare the risk Chronic Disease (CKD), End Stage Renal (ESRD) critically without severe AKI.This cohort study was conducted between 2005 2011 Swedish intensive care...
We wanted to assess if "Explainable AI" in the form of extreme gradient boosting (XGBoost) could outperform traditional logistic regression predicting myocardial infarction (MI) a large cohort. Two machine learning methods, XGBoost and regression, were compared risk MI. The UK Biobank is population-based prospective cohort including 502 506 volunteers with active consent, aged 40 69 years at recruitment from 2006 2010. These subjects followed until end 2019 primary outcome was infarction....
Abstract Background The coronavirus disease 2019 (COVID-19) disproportionately affects minority populations in the USA. Sweden — like other Nordic countries have less income and wealth inequality but lacks data on socioeconomic impact risk of adverse outcomes due to COVID-19. Methods This population-wide study from March 2020 2022 included all adults Stockholm, except those nursing homes or receiving in-home care. Data sources include hospitals, primary care (individual diagnoses), Swedish...
Abstract The metabolism of chylomicrons, very-low-density lipoprotein (VLDL), and their remnants in the postprandial state was studied normolipidemic healthy men by measuring apoB-48 apoB-100 retinyl palmitate (RP) fractions triglyceride-rich lipoproteins after a mixed meal type oral fat load supplemented with vitamin A. ApoB-48 present at low concentrations fasting plasma samples most subjects increased response to test Svedberg’s flotation rate (Sf) >20 fractions. Concomitantly, level...
<h3>Objective:</h3> To examine the risk of subsequent sepsis in individuals with coeliac disease. <h3>Design:</h3> We used Swedish national health registers to identify 15 325 a diagnosis disease (1964–2003) and 14 494 inpatient reference individuals. Cox regression estimated hazard ratios (HRs) for sepsis. <h3>Results:</h3> Compared individuals, were at increased (HR = 1.6, 95% confidence interval (95% CI) 1.2 1.9, p<0.001). The highest estimates seen pneumococcal 2.5, CI 5.1, p 0.014)....
Purpose . To assess urinary tissue inhibitor of metalloproteinases-2 and insulin-like growth factor binding protein 7 ([TIMP-2]·[IGFBP7]), neutrophil gelatinase-associated lipocalin (NGAL), cystatin-C as acute kidney injury predictors (AKI) exploring the association nonrenal factors with elevated biomarker levels. Methods We studied 94 patients urine collected within 48 hours ICU admission no AKI at sampling. was defined by Kidney Disease: Improving Global Outcomes criteria. Predictive...
Prevalence of chronic kidney disease (CKD) amongst intensive care unit (ICU) admissions is rising. How mortality and risk end-stage renal (ESRD) differs between those with without CKD acute injury (AKI) unclear. Determining factors that increase the ESRD essential to optimise treatment, identify patients requiring nephrological surveillance for quantification dialysis provision.This cohort study used Swedish register 2005-2011 consisting 130,134 adult patients. Incomplete cases were excluded...
Perioperative acute kidney injury (AKI) is common and increases the risk of morbidity mortality.To determine association between intraoperative hypotension, defined as an individual decrease from baseline perioperative AKI.Observational cohort study.Karolinska University Hospital, Stockholm, Sweden, October 2012 to May 2013 2015 April 2016.All adult patients undergoing major elective noncardiac surgery who were scheduled for overnight admission in postoperative unit included. Patients...
BACKGROUND Perioperative myocardial damage and infarction (MI) is associated with increased mortality other postoperative complications. OBJECTIVES To assess the incidence of perioperative in patients undergoing major elective noncardiac surgery, to elucidate any association MI estimate impact preoperative risk factors intraoperative hypotension. DESIGN Observational cohort study. SETTING Karolinska University Hospital, Stockholm, Sweden, from October 2012 May 2013. PATIENTS In this...
BACKGROUND: Hemodynamic instability during anesthesia and surgery is common associated with cardiac morbidity mortality. Information needed regarding optimal blood pressure (BP) threshold in the perioperative period. Therefore, effect of intraoperative hypotension (IOH) on risk myocardial infarction (MI) was explored. METHODS: A nested case-control study patients developing MI <30 days postsurgery matched non–MI patients, sampled from a large cohort. Study participants were adults...
Since the beginning of Covid-19 pandemic, scientific community has explored determinants Covid 19 disease severity. However, majority studies are based on in-hospital patients with high risk collider- or selection bias. The present investigation details factors associated overall mortality, hospitalization and intensive care unit (ICU) admission in infections, complete population coverage high-resolution data patient characteristics comorbid conditions This population-based observational...