A5073624190- Olfactory and Sensory Function Studies
- Single-cell and spatial transcriptomics
- COVID-19 Clinical Research Studies
- T-cell and Retrovirus Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Molecular Biology Techniques and Applications
- Immune responses and vaccinations
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Animal Disease Management and Epidemiology
- Machine Learning in Bioinformatics
- Virology and Viral Diseases
- SARS-CoV-2 and COVID-19 Research
- Vector-Borne Animal Diseases
- CRISPR and Genetic Engineering
Neurological Research Institute
2025
Texas Children's Hospital
2025
Baylor College of Medicine
2024-2025
Research Network (United States)
2025
The University of Texas Health Science Center at Houston
2021-2023
The University of Texas MD Anderson Cancer Center
2021-2023
Emory University
2017
Single-cell genomics has revolutionized our understanding of cellular heterogeneity, but automating its analysis remains an open challenge. Cell-type annotation represents a critical bottleneck, particularly as datasets grow in size and complexity. While foundation models have shown promise addressing this challenge, existing approaches require extensive fine-tuning for effective cell-type annotation. Here, we present Lemur, single-cell model specifically designed Drosophila melanogaster ....
Olfactory sensory neurons within the nasal epithelium detect volatile odorants and relay odor information to central nervous system. Unlike other inputs, olfactory interface with external environment project their axons directly into The use of adeno-associated viruses target these has garnered interest for applications in gene therapy, probing neuron biology, modeling disease. To date, there is no consensus on optimal AAV serotype efficient selective transduction vivo. Here we utilized...
Single-cell RNA sequencing of the bronchoalveolar lavage fluid (BALF) samples from COVID-19 patients has enabled us to examine gene expression changes human tissue in response SARS-CoV-2 virus infection. However, underlying mechanisms pathogenesis at single-cell resolution, its transcriptional drivers, and dynamics require further investigation. In this study, we applied machine learning algorithms infer trajectories cellular identify their programs. Our study generated that show...
Human T-cell leukemia virus type 1 (HTLV-1), a retrovirus, is the causative agent for adult T cell leukemia/lymphoma and many other human diseases. Accurate high throughput detection of HTLV-1 integration sites (VISs) across host genomes plays crucial role in prevention treatment HTLV-1-associated Here, we developed DeepHTLV, first deep learning framework VIS prediction de novo from genome sequence, motif discovery, cis-regulatory factor identification. We demonstrated accuracy DeepHTLV with...
Olfactory sensory neurons within the nasal epithelium detect volatile odorants and relay odor information to central nervous system. Unlike other inputs, olfactory interface with external environment project their axons directly into The use of adeno-associated viruses target these has garnered interest for applications in gene therapy, probing neuron biology, modeling disease. To date, there is no consensus on optimal AAV serotype efficient selective transduction vivo. Here we utilized...
SUMMARYHuman T-lymphotrophic virus 1 (HTLV-1), a retrovirus, is the causative agent for adult T-cell leukemia/lymphoma (ATL) and many other human diseases. Accurate high throughput detection of HTLV-1 integration sites (VISs) across host genomes plays crucial role in prevention treatment associated Here, we developed DeepHTLV, first deep learning framework VIS prediction de novo from genome sequence, motif discovery cis-regulatory factor identification. We demonstrated accuracy DeepHTLV with...