A5019112270- Nanoparticle-Based Drug Delivery
- Nanoparticles: synthesis and applications
- Nanoplatforms for cancer theranostics
- Wnt/β-catenin signaling in development and cancer
- Graphene and Nanomaterials Applications
- Glioma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Optical Imaging and Spectroscopy Techniques
- Long-Term Effects of COVID-19
- Endoplasmic Reticulum Stress and Disease
- Neuroscience and Neural Engineering
- Cellular transport and secretion
- Head and Neck Cancer Studies
- Autophagy in Disease and Therapy
- Molecular Communication and Nanonetworks
- SARS-CoV-2 and COVID-19 Research
- Bone Tissue Engineering Materials
- Pharmaceutical Economics and Policy
- Tryptophan and brain disorders
- Photoacoustic and Ultrasonic Imaging
- Developmental Biology and Gene Regulation
- Immune responses and vaccinations
- Microfluidic and Bio-sensing Technologies
- Anesthesia and Neurotoxicity Research
University of Southern California
2010-2024
Keck Hospital of USC
2010-2024
Brain Mapping Foundation
2020-2023
USC Norris Comprehensive Cancer Center
2020-2023
Broad Center
2008-2013
Keck Graduate Institute
2011
Southern California University for Professional Studies
2010
California Institute of Technology
2004
Exonic deletions in NRXN1 have been associated with several neurodevelopmental disorders, including autism, schizophrenia and developmental delay. However, the molecular mechanism by which impact neurodevelopment remains unclear. Here we used human induced pluripotent stem cells (hiPSCs) embryonic (hESCs) as models to investigate functional impacts of knockdown. We first generated hiPSCs from skin fibroblasts differentiated them into neural (NSCs). reduced expression NSCs via a controlled...
Neural progenitor cells (NPCs) are multipotent that can self-renew and differentiate into neurons glial cells. However, mechanisms control their fate decisions poorly understood. Here, we show Smek1, a regulatory subunit of the serine/threonine protein phosphatase PP4, promotes neuronal differentiation suppresses proliferative capacity NPCs. We identify cell polarity Par3, negative regulator differentiation, as Smek1 substrate demonstrate its activity. also which is predominantly nuclear in...
Head and neck squamous cell carcinoma (HNSCC) is one of the leading causes cancer-related death worldwide. Surgical resection, radiation chemotherapy are mainstay HNSCC treatment but often unsatisfactory. Cisplatin a commonly used in HNSCC; however, cisplatin resistance major cause relapse death. The 78-kD glucose-regulated protein (GRP78) master regulator unfolded response (UPR) implicated therapeutic cancer. role GRP78 remains unclear. YUM70 newly discovered hydroxyquinoline analogue found...
Pain generator-based lumbar spinal decompression surgery is the backbone of modern spine care. In contrast to traditional image-based medical necessity criteria for surgery, assessing severity neural element encroachment, instability, and deformity, staged management common painful degenerative conditions likely be more durable cost-effective. Targeting validated pain generators can accomplished with simplified procedures associated lower perioperative complications long-term revision rates....
Alternating electric fields (AEF) therapy is a treatment modality for patients with glioblastoma. Tumor characteristics such as size, location, and extent of peritumoral edema may affect the AEF strength distribution. We evaluated sensitivity AEFs in realistic 3D rat glioma model respect to these properties.
Background: Endoscopically visualized spine surgery has become an essential tool that aids in identifying and treating anatomical pathologies are not well demonstrated by traditional advanced imaging, including MRI. These may be during endoscopic lumbar decompression (ELD) categorized into primary pain generators (PPG). Identifying these PPGs provides crucial information for a successful outcome with ELD forms the basis our proposed personalized care protocol (SpineScreen). Methods:...
The 78-kDa glucose regulated protein (GRP78) commonly upregulated in a wide variety of tumors is an important prognostic marker and promising target for suppressing tumorigenesis treatment resistance. While GRP78 well established as major endoplasmic reticulum (ER) chaperone with anti-apoptotic properties master regulator the unfolded response, its new role oncoprotein expression just emerging. MYC dysregulated about 70 % human cancers most activated oncoprotein. However, despite recent...
Background: There are no data available on the levels of genetic networks between obsessive-compulsive disorder (OCD) and multiple sclerosis (MS). To this point, we aimed to investigate common mechanisms pathways using bioinformatics approaches find novel genes that may be involved in pathogenesis OCD MS. Methods: obtain gene-gene interactions for MS OCD, STRING database was used. Cytoscape then used reconstruct visualize graphs. Then, ToppGene Enrichr were identify main pathological...