A5020510587- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Congenital Diaphragmatic Hernia Studies
- Clinical Nutrition and Gastroenterology
- Anesthesia and Neurotoxicity Research
- Congenital Anomalies and Fetal Surgery
- Neonatal and fetal brain pathology
- Intensive Care Unit Cognitive Disorders
- Organ Transplantation Techniques and Outcomes
- COVID-19 Impact on Reproduction
- Cardiac Ischemia and Reperfusion
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Nutrition and Health in Aging
- Intestinal Malrotation and Obstruction Disorders
- Folate and B Vitamins Research
- Neuroendocrine regulation and behavior
- Hernia repair and management
- Pregnancy and preeclampsia studies
- Regulation of Appetite and Obesity
- Infant Development and Preterm Care
- Digestive system and related health
- Neuroscience of respiration and sleep
- Appendicitis Diagnosis and Management
Hospital for Sick Children
2018-2025
University of Toronto
2018-2025
SickKids Foundation
2018-2025
Biologie du Développement et Cellules Souches
2024
Necrotizing enterocolitis (NEC) is an inflammatory gastrointestinal disease primarily affecting preterm neonates. Neonates with NEC suffer from a degree of neurodevelopmental delay that not explained by prematurity alone. There need to understand the pathogenesis in NEC. In this study, we assessed macroscopic and microscopic changes occur brain cell populations specific regions neonatal mouse model Moreover, investigated role intestinal inflammation as part mechanism responsible for observed...
Pulmonary hypoplasia secondary to congenital diaphragmatic hernia (CDH) is characterized by impaired branching morphogenesis and differentiation. We have previously demonstrated that administration of extracellular vesicles derived from rat amniotic fluid stem cells (AFSC-EVs) rescues development hypoplastic lungs at the pseudoglandular alveolar stages in rodent models CDH. Herein, we tested whether AFSC-EVs exert their regenerative effects canalicular saccular stages, as these are...
Necrotizing enterocolitis (NEC) is one of the most severe gastrointestinal diseases affecting premature infants. It has been shown that NEC associated with disrupted intestinal barrier and dysregulated endoplasmic reticulum (ER)-stress response. also stem cells derived from amniotic fluid (AFSC) rescued injury in experimental NEC. Herein, we hypothesized beneficial effects AFSC injured intestine are due to restoration function. We evaluated function using an ex vivo organoid model found...
Introduction: Neonatal necrotizing enterocolitis (NEC) is a severe gastrointestinal disorder with high mortality, characterized by epithelial cell injury and compromised repair. The mechanisms underlying defective regeneration remain poorly understood despite advances in single-cell omics. Addressing these challenges essential for elucidating the pathogenesis of NEC identifying therapeutic targets to restore replace damaged layer. Methods: Multi-omics approaches were employed investigate...
Abstract Congenital diaphragmatic hernia (CDH) is a birth defect characterized by incomplete closure of the diaphragm, herniation abdominal organs into chest, and compression lungs heart. Besides complications related to pulmonary hypoplasia, 1 in 4 survivors develop neurodevelopmental impairment, whose etiology remains unclear. Using fetal rat model CDH, we demonstrated that exerted herniated on mediastinal structures results decreased brain perfusion ultrafast ultrasound, cerebral hypoxia...
Abstract Oligohydramnios (decreased amniotic fluid volume for gestational age) is a severe condition associated with high morbidity and mortality mainly due to fetal pulmonary hypoplasia. Currently, there are limited treatment options promote lung development. Administration of stem cells their derivates have shown promising regenerative properties several neonatal diseases related arrested Herein, we first characterized hypoplasia secondary oligohydramnios in surgical rat model....
Abstract Congenital diaphragmatic hernia (CDH) is a birth defect characterized by incomplete closure of the diaphragm, herniation abdominal organs into chest, and compression lungs heart. Besides complications related to pulmonary hypoplasia, 1 in 4 survivors develop neurodevelopmental impairment, whose etiology remains unclear. Using fetal rat model CDH, we demonstrated that exerted herniated on mediastinal structures results decreased brain perfusion ultrafast ultrasound, cerebral hypoxia...
ABSTRACT Pulmonary hypoplasia secondary to congenital diaphragmatic hernia (CDH) is characterized by impaired branching morphogenesis and differentiation. We have previously demonstrated that administration of extracellular vesicles derived from rat amniotic fluid stem cells (AFSC-EVs) rescues development hypoplastic lungs at the pseudoglandular alveolar stages in rodent models CDH. Herein, we tested whether AFSC-EVs exert their regenerative effects canalicular saccular stages, as these are...
Abstract Purpose Necrotizing enterocolitis (NEC), an inflammatory intestinal disease common in premature infants, has been associated with the development of lung damage. Toll-like receptor 4 shown to regulate inflammation NEC lungs, however, other important mechanisms have not thoroughly investigated. In addition, we reported that milk-derived exosomes were able attenuate injury and experimental NEC. This study aims (i) investigate role NLRP3 inflammasome NF-κB pathway regulating damage...