A5029269330- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- Neuroblastoma Research and Treatments
- Neonatal Respiratory Health Research
- Cell death mechanisms and regulation
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Cutaneous Melanoma Detection and Management
University of California, San Diego
2023
UC San Diego Health System
2023
University of Cape Town
2018-2020
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an insidious disease with a low 5-year survival rate. PDAC characterized by infiltration of abundant tumor-associated macrophages (TAM), which promote immune tolerance and immunotherapeutic resistance. Here we report that macrophage spleen tyrosine kinase (Syk) promotes growth metastasis. In orthotopic mouse models, genetic deletion myeloid Syk reprogrammed into immunostimulatory phenotype, increased the infiltration, proliferation,...
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