A5044996218- Curcumin's Biomedical Applications
- Genomics, phytochemicals, and oxidative stress
- Retinoids in leukemia and cellular processes
- Peroxisome Proliferator-Activated Receptors
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Eicosanoids and Hypertension Pharmacology
- Lipid metabolism and biosynthesis
- Autophagy in Disease and Therapy
Jimei University
2022-2023
As a natural polyphenolic food supplement and the principal curcuminoid in turmeric, curcumin shows antioxidant, anti-inflammatory, antitumor activities. However, its specific functional mechanism remains unclear. Our preliminary study indicated that miR-125b-5p was downregulated by extract. This aimed to determine whether is involved antioxidant regulation of curcumin. The results showed overexpression had pro-oxidant effect reducing cellular capacity, as well decreasing activities catalase...
The antioxidant activity of curcumin has been extensively investigated for years. However, its molecular function mechanism remained unclear. Our preliminary study showed that downregulated miR-22-3p expression. This aimed to address whether mediated the and possible action mechanism. results repression increased total cellular capacity enhanced endogenous enzyme system LO2 cells. In addition, miR-22-3p-deteriorated was prevented by pretreatment. Moreover, inhibition significantly improved...
1. Abenavoli, L., Larussa, T., Corea, A., Procopio, A.C., Boccuto, Dallio, M., Federico, Luzza, F. (2021). Dietary polyphenols and non-alcoholic fatty liver disease. Nutrients, 13(2), art. no. 494. https://doi.org/10.3390/nu1302.... CrossRef Google Scholar
Objective: Oxidative stress represents a characteristic of neurodegenerative diseases, which may be alleviated by the functional food component—curcumin. However, underlying mechanism remains unclear. The current study aimed to address how curcumin protects variant differentiated pheochromocytoma (PC12) cells against hydrogen peroxide (H 2 O )-induced cell stress, using low- and high-differentiated PC12 cells, validated in old-aged mice. Methods: MTT assay was first carried out test...