A5054981562- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Synthesis of β-Lactam Compounds
- Natural Compounds in Disease Treatment
- Alkaloids: synthesis and pharmacology
- Healthcare and Venom Research
- Pharmacological Effects of Natural Compounds
- Acupuncture Treatment Research Studies
- Pain Mechanisms and Treatments
- Rheumatoid Arthritis Research and Therapies
- Plant-based Medicinal Research
- Osteoarthritis Treatment and Mechanisms
- Neuropeptides and Animal Physiology
- Natural product bioactivities and synthesis
- Blood Coagulation and Thrombosis Mechanisms
- Traditional Chinese Medicine Studies
- Sleep and Wakefulness Research
- Venomous Animal Envenomation and Studies
- Drug Transport and Resistance Mechanisms
- Biochemical Analysis and Sensing Techniques
- Knee injuries and reconstruction techniques
- Urinary Bladder and Prostate Research
- Cancer Cells and Metastasis
- Colorectal and Anal Carcinomas
- Ocular Diseases and Behçet’s Syndrome
Showa University
2016-2025
Showa University Fujigaoka Hospital
2023-2025
Showa University Koto Toyosu Hospital
2023
Yangzhou University
2018-2019
University of Pittsburgh
2013-2014
Showa University Hospital
2013
University of the Ryukyus
1995-2000
University of Cincinnati Medical Center
2000
Sumitomo Dainippon Pharma (Japan)
1992-1997
Sumitomo Chemical (United States)
1996
The stability of meropenem in the presence renal dehydropeptidase I (DHP-I) varied extremely with animal source enzyme. Meropenem, compared imipenem, was rather easily hydrolyzed by DHP-Is from mice, rabbits, and monkeys, while it showed a higher resistance to guinea pig beagle dog DHP-Is. In addition, four times more resistant than imipenem human DHP-I. 1 beta-methyl substituent on carbapenems, i.e., made them considerably mouse swine 1-unsubstituted derivatives are.
Invasion of fibroblast-like synoviocytes (FLSs) is critical in the pathogenesis rheumatoid arthritis (RA). The metalloproteinases (MMPs) and activator Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) pathway play a role RA-FLS invasion induced by lipopolysaccharide (LPS). present study aimed to explore anti-invasive activity celastrol on LPS-stimulated human RA-FLSs, elucidate mechanism involved. We investigated effect LPS-induced FLS migration as well MMP expression explored upstream...
Abstract Background Gastric cancer (GC) tumorigenesis and treatment failure are caused by stem cells. Polypyrimidine tract binding protein 1 (PTBP1) was shown to be involved in the development of embryonic cells is now being considered as a therapeutic target for tumour progression stem-cell characteristics. Methods PTBP1 expression GC samples detected using tissue microarrays. Proliferation, colony formation, spheroid formation analysis were used examine PTBP1’s role maintenance. In AGS...
A number of modern researchers have studied the relationship between religion and health. In every religious tradition, virtues such as self-sacrifice, altruism, appreciation been considered quite essential. Arigato-Zen (AZ) (Gratitude Zen) is an easy simple voice-meditation developed by Dr. Machida, which motivates feeling altruism appreciation. By performing AZ, one able to cleanse negative subconscious memories that underlie problematic phenomena. Hypothalamic oxytocin (OT) plays...
Mechanical stress on the ocular surface, such as from eye-rubbing, has been reported to lead inflammation and various conditions. We hypothesized that mechanosensitive Piezo1 channel in conjunctival epithelium contributes inflammatory response at surface after receiving mechanical stimuli. Human epithelial cells (HConjECs) were treated with Yoda1, a Piezo1-specific agonist, allergens measure cytokine expression levels using qRT-PCR. activation-induced intracellular signaling pathways also...
Background Knee osteoarthritis (KOA) is a prevalent and chronic condition characterized by swelling, pain, limited range of motion the knee due to degenerative changes in joint structures, leading impairment performing daily activities. Although conservative treatments, such as exercise therapy nonsteroidal anti-inflammatory drugs are employed, there few effective therapeutic options for preventing disease progression. During early KOA, osteoclast proliferation subchondral bone, disruption...
Abstract Aim This study aims to assess the motivation, capability, and working environment of Japanese traditional (Kampo) medicine (JTM) specialists certified physicians affiliated with Japan Society for Oriental Medicine regarding clinical research. Their awareness perception COVID‐19 studies their interest in research based on JTM diagnostic concepts are explored. Methods An online survey was conducted between May 20 June 30, 2024, using Google Forms, targeting 2146 Medicine‐certified...
Objective . This study was designed to evaluate the clinical efficacy of combined traditional Chinese medicine (TCM) and conventional chemotherapy versus in patients with stage II‐IIIA non‐small‐cell lung cancer (NSCLC) after radical surgery. Methods A retrospective cohort conducted NSCLC from Subei People′s Hospital Yangzhou Traditional Medicine City Jiangsu Province 2012 2016. Patients were divided into two groups: TCM user group (patients receiving treatment integrated chemotherapy)...
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the hyperproliferation and invasive behavior of rheumatoid fibroblast-like synoviocytes (RA-FLS), which contributes to degradation articular cartilage bone. Inhibition RA-FLS proliferation, migration invasion has become an important therapeutic strategy for RA. Triptolide (TPL), epoxy diterpene lactone compound from traditional Chinese medicine Tripterygium wilfordii Hook. f., significant immunosuppressive...
Introduction. Medical care for Japanese cancer patients includes Western and Kampo medicines, treatments with juzentaihoto (JTT) reportedly prevent metastasis recurrence. In this study, we examined the effects of JTT on natural killer (NK) cell activity in combined anti-PD-1 antibody a mouse model melanoma metastasis. Methods. C57BL/6 male mice were intravenously injected B16 cells (B16 cell) given chow containing 3% JTT. subsequent vivo experiments, assessed serum cytokine levels tumor...
The stability and the degradation products of 1 beta-methylcarbapenem, meropenem in aqueous solution were investigated. In pH 4-8 dilute solution, pseudo-first-order was observed, good demonstrated by effect beta-methyl group against hydrolysis beta-lactam ring. As products, hydrolyzed product dimer resulting from intermolecular aminolysis ring amine second molecule described.
To investigate the effect of mechanical stress on periostin and semaphorin-3A expression in a murine model postmenopausal osteoporosis osteoblast-like MC3T3-E1 cells.Female mice were divided into three groups treated with sham operation, ovariectomy (OVX) or OVX plus treadmill training (OVX+Run). After 10 weeks, tibias used for histological analysis. cells burdened by using centrifuge periostin, production biologically-active was examined vitro.In OVX+Run group tibias, number...
For decades, the traditional Chinese medicine preparation, Huachansu Capsule (HCS), has been applied to a variety of solid tumors and leukemias with significant curative effects. More importantly, HCS few side effects on cardiovascular gastrointestinal functions in patients. However, potential mechanism anti-tumor activity not fully revealed. The current study investigated vivo vitro proliferation apoptosis human gastric cancer (GC) cells explored underlying mechanism. was first diluted...
Substantial evidence suggests the effectiveness of plant-based medicine in stress-related diseases. Kamikihito (KKT), a Japanese traditional herbal (Kampo), has been used for anemia, insomnia, and anxiety. Recent studies revealed its ameliorating effect on cognitive memory dysfunction several animal models. We, therefore, determined whether daily supplementation KKT an antidepressant-like stress-induced behavioral neurological changes rats.The against anxiety- depressive-like behaviors...
Nitric oxide (NO) is known to play pivotal roles as one of the final effector molecules in development allergic diseases, including rhinitis (AR). Although quercetin has been reported attenuate clinical conditions AR, its influence on NO production not well defined. The present study aimed examine vitro from nasal epithelial cells after interleukin- (IL-) 4 stimulation. Human (HNEpCs) at a concentration 1 x 105 cells/ml were stimulated with 10.0 ng/ml IL-4 presence and absence quercetin....
Background: Angiogenesis is well known to be an important event in the tissue remodeling observed allergic diseases. Although there much evidence that quercetin, one of most abundant dietary flavonoids, exerts anti-allergic effects both human and experimental animal models diseases, action quercetin on angiogenesis has not been defined. Therefore, this study, we first examined secretion angiogenic factors from murine mast cells vitro. We also factor rhinitis model vivo. Methods: Mast (1 ×...