A5085401423- Alzheimer's disease research and treatments
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Cholinesterase and Neurodegenerative Diseases
- Memory and Neural Mechanisms
- Neurological Disease Mechanisms and Treatments
- Gut microbiota and health
- Medicinal Plants and Neuroprotection
- Apelin-related biomedical research
- Nuclear Receptors and Signaling
- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Neuroendocrine regulation and behavior
- Biochemical Acid Research Studies
- Sirtuins and Resveratrol in Medicine
- Olfactory and Sensory Function Studies
- Pancreatic function and diabetes
- S100 Proteins and Annexins
- Regulation of Appetite and Obesity
- Metabolism, Diabetes, and Cancer
- Fatty Acid Research and Health
Universidad de Navarra
2016-2025
Navarre Institute of Health Research
2016-2024
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2014-2016
University of Cologne
2014-2016
University Hospital Cologne
2014-2016
Max Planck Institute for Metabolism Research
2014-2016
Lavender essential oil is traditionally used and approved by the European Medicines Agency as herbal medicine to relieve stress anxiety. Some animal clinical studies reveal positive results in models of anxiety depression although very little research has been done on molecular mechanisms. Our work consisted evaluating effects lavender (Lavandula angustifolia) central nervous system well-established targets such MAO-A, SERT, GABAA NMDA receptors well vitro neurotoxicity. The showed that its...
One of the most biologically relevant functions astrocytes within CNS is regulation synaptic transmission, i.e., physiological basis for information transmission between neurons. Changes in strength connections are indeed thought to be cellular learning and memory. Importantly, have been demonstrated tightly regulate these processes via release several gliotransmitters linked astrocytic calcium activity as well astrocyte–neuron metabolic coupling. Therefore, seem integrators actors upon...
c-Jun N-terminal kinase 3 (JNK3) is suggested to play a key role in neurodegenerative disorders, especially Alzheimer's disease (AD). However, it remains unclear whether JNK or amyloid β (Aβ) appears first the onset. Postmortem brain tissues from four dementia subtypes of patients (frontotemporal dementia, Lewy body vascular and AD) were used measure activated (pJNK) Aβ levels. pJNK expression significantly increased AD; however, similar was found other dementias. Furthermore, there...
The present work investigated the involvement of cortisol and its receptors, glucocorticoid receptor (GR) mineralocorticoid (MR), in Alzheimer's disease (AD). Cortisol was measured cerebrospinal fluid (CSF) samples from controls, mild
Previous studies have failed to reach consensus on insulin levels in cerebrospinal fluid of Alzheimer's disease (AD) patients and its relation pathological features. We performed a new analysis at different stages AD, investi
Stress is believed to be associated with the development of neuropsychiatric disorders, including Alzheimer's disease (AD). We have studied mechanisms implicated in vulnerability stress and relationship changes AD-related markers.Anhedonia induced by a chronic mild (CMS) procedure, applied for 6 weeks, was used select rats vulnerable or resistant stress. Sucrose intake, Porsolt forced swimming test cognitive deficits novel object recognition (NORT) were characterize resilient rats. The...
It has been established that ageing is the major risk factor for cognitive deficiency and it becoming increasingly evident insulin resistance another factor. Biological plausibility a link between dementia relevant understanding disease etiology, to form bases prevention efforts decrease burden. In present study, peripheral central was found in SAMP8 mice (aging mouse model) accompanied by deficiencies. Furthermore, marked inflammatory state observed mice, followed neuroinflammation could be...
Recent evidence suggests that activity-regulated cytoskeleton associated protein (Arc) and brain-derived neurotrophic factor (BDNF) are key players in the cellular mechanisms trigger synaptic changes memory consolidation. Cholinergic deafferentiation of hippocampus has been largely shown to induce impairments different behavioral tasks. However, underlying cholinergic-induced formation remain unclear. The role hippocampal cholinergic denervation on consolidation further acquisition spatial...
ABSTRACT Alzheimer's disease (AD) is characterized phenotypically by memory impairment, histologically accumulation of pTau and β‐amyloid peptide morphologically a loss nerve terminals in cortical hippocampal regions. As glutamate the principle excitatory neurotransmitter central nervous system (CNS), glutamatergic may play an important role AD. To date, not many studies have addressed deleterious effects Aβ on terminals; therefore aim this study was to investigate how affects assess extent...
Abstract Alzheimer's disease (AD) is the most common form of dementia, characterized by an early olfactory dysfunction, progressive memory loss, and behavioral deterioration. Albeit substantial progress has been made in characterizing AD‐associated molecular cellular events, there unmet clinical need for new therapies. In this study, tract proteotyping performed controls AD subjects ( n = 17/group) showed a Braak stage‐dependent proteostatic impairment accompanied modulation amyloid...
Astrocytes are considered an essential source of blood-borne glucose or its metabolites to neurons. Nonetheless, the necessity main astrocyte transporter, i.e., GLUT1, for brain metabolism has not been defined. Unexpectedly, we found that was paradoxically augmented in mice with astrocytic GLUT1 reduction (GLUT1 ΔGFAP mice). These also exhibited improved peripheral especially obesity, rendering them metabolically healthier. Mechanistically, observed GLUT1-deficient astrocytes increased...