A5050475151- Primary Care and Health Outcomes
- Health Sciences Research and Education
- Nursing Diagnosis and Documentation
- Health and Medical Research Impacts
- Musculoskeletal Disorders and Rehabilitation
- Nursing Education, Practice, and Leadership
- Health Education and Validation
- Congenital heart defects research
- Autism Spectrum Disorder Research
- Medical Coding and Health Information
- Pharmaceutical Economics and Policy
- Immunodeficiency and Autoimmune Disorders
- Tissue Engineering and Regenerative Medicine
- Migration, Health and Trauma
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Biomedical Ethics and Regulation
- Law, AI, and Intellectual Property
- Hippo pathway signaling and YAP/TAZ
- Biomedical Text Mining and Ontologies
- Cellular Mechanics and Interactions
- School Health and Nursing Education
- Renal and related cancers
- Medical Research and Practices
- Visual Culture and Art Theory
University of Massachusetts Chan Medical School
2016-2021
Boston Children's Hospital
2011-2015
Harvard University Press
2011
Harvard Stem Cell Institute
2011
Harvard University
2011
Penn State Milton S. Hershey Medical Center
2003
Medical College of Wisconsin
2003
St. Joseph's Hospital
2003
Heart growth is tightly controlled so that the heart reaches a predetermined size. Fetal occurs through cardiomyocyte proliferation, whereas postnatal involves primarily physiological hypertrophy. The Hippo kinase cascade an important regulator of organ growth. A major target this YAP1, transcriptional coactivator inactivated by activity. Here, we used both genetic gain and loss Yap1 function to investigate its role in regulating proliferative physiologic hypertrophic inactivation caused...
The epicardium makes essential cellular and paracrine contributions to the growth of fetal myocardium formation coronary vasculature. However, whether has similar roles postnatally in normal injured heart remains enigmatic. Here, we have investigated this question using genetic fate-mapping approaches mice. In uninjured postnatal heart, epicardial cells were quiescent. Myocardial infarction increased cell proliferation stimulated epicardium-derived (EPDCs), which remained a thickened layer...
Myocardial infarction (MI) is one of the leading causes morbidity and mortality world-wide. Whether endogenous repair regenerative ability could be augmented by drug administration an important issue for generation novel therapeutic approach. Recently it was reported that in mice pretreated with thymosin beta 4 (TB4) subsequently subjected to experimental MI, a subset epicardial cells differentiated into cardiomyocytes. In clinical settings, priming TB4 prior MI impractical. Here we tested...
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Data sharing and reuse, while widely accepted as good ideas, have been slow to catch on in any concrete consistent way. One major hurdle within the scientific community has lack of standards for citing that data, making it difficult track usage measure impact. Within neuroimaging community, there is a need way not only clearly identify cite datasets, but also derive new aggregate sets from multiple sources, maintaining lines attribution. This work presents functional prototype system...
Background: The degree of reproducibility the neuroimaging literature in psychiatric application areas has been called into question and issues that relate to this are extremely complex. Some these complexities have do with underlying biology disorders we study others arise due technology apply analysis data collect. Ultimately, observations make get communicated rest community through publications scientific literature. Methods: We sought perform a 're-executability survey' evaluate recent...
<ns3:p><ns3:bold>Background:</ns3:bold> The degree of reproducibility the neuroimaging literature in psychiatric application areas has been called into question and issues that relate to this are extremely complex. Some these complexities have do with underlying biology disorders we study others arise due technology apply analysis data collect. Ultimately, observations make get communicated rest community through publications scientific literature.</ns3:p><ns3:p>...