About
Contact & Profiles
A5007534473
Research Areas
- Genomic variations and chromosomal abnormalities
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
Technical University of Munich
2023
In contrast to mono- or biallelic loss of tumor-suppressor function, effects discrete gene dysregulations, as caused by non-coding (epi)genome alterations, are poorly understood. Here, perturbing the regulatory genome in mice, we uncover pervasive roles subtle expression variation cancer evolution. Genome-wide screens characterizing 1,450 tumors revealed that such quasi-insufficiency is extensive across entities and displays diverse context dependencies, distinct cell-of-origin associations...
10.1016/j.xgen.2023.100276
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Cell Genomics
2023-03-01
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