A5062801123- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Infectious Encephalopathies and Encephalitis
- Glioma Diagnosis and Treatment
- Radiation Dose and Imaging
- Radiology practices and education
- Organ Transplantation Techniques and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Tissue Engineering and Regenerative Medicine
- Electron and X-Ray Spectroscopy Techniques
- 3D Printing in Biomedical Research
- COVID-19 diagnosis using AI
- Case Reports on Hematomas
- Advanced Electron Microscopy Techniques and Applications
- Liver Disease and Transplantation
- Thyroid and Parathyroid Surgery
- Digital Radiography and Breast Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 Clinical Research Studies
- Meningioma and schwannoma management
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Neurological and metabolic disorders
- COVID-19 and healthcare impacts
Singapore General Hospital
2015-2024
SingHealth Duke-NUS Academic Medical Centre
2024
National University Hospital
2024
National University of Singapore
2024
National Neuroscience Institute
2024
University of Pennsylvania
2023
Duke-NUS Medical School
2014-2023
Both liver resection (LR) and cadaveric transplantation (CLT) are potentially curative treatments for patients with hepatocellular carcinoma (HCC) within the Milan criteria adequate function. Adopting either as a first-line therapy carries major cost resource implications. The objective of this study was to estimate relative cost-effectiveness LR against CLT HCC using decision analytic model. A Markov cohort model developed simulate aged 55 years Child-Pugh A/B cirrhosis, undergoing or CLT,...
Rationale: Previous studies have shown that human embryonic stem cell-derived cardiomyocytes improved myocardial recovery when administered to infarcted pig and non-human primate hearts.However, the engraftment of intramyocardially delivered cells is poor effectiveness clinically relevant doses induced pluripotent (hiPSC-CMs) in large animal models injury remains unknown.Here, we determined whether thymosin β4 (Tb4) could improve reparative potency transplanted hiPSC-CMs a porcine model...
To globally survey the changes in transcriptional landscape during terminal erythroid differentiation, we performed RNA sequencing (RNA-seq) on primary human CD34+ cells after ex vivo differentiation from earliest into most mature cell stages. This analysis identified thousands of novel intergenic and intronic transcripts as well alternative transcript isoforms. After rigorous data filtering, 51 (presumptive) protein-coding transcripts, 5326 long 679 small non-coding candidates remained. The...
The isocitrate dehydrogenase (IDH) mutation has become one of the most important prognostic biomarkers in glioma management, indicating better treatment response and prognosis. IDH mutations confer neomorphic activity leading to conversion alpha-ketoglutarate (α-KG) 2-hydroxyglutarate (2HG). purpose this study was investigate clinical potential proton MR spectroscopy (1H-MRS) identifying IDH-mutant gliomas by detecting characteristic resonances 2HG its complex interplay with other clinically...
The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented challenge to the health care systems of world. In Singapore, early experiences radiology community on managing this was shaped by lessons learned from severe acute respiratory syndrome outbreak in 2003. This article surveys operational responses departments six public hospitals Singapore. © RSNA, 2020.
Purpose
 Isocitrate dehydrogenase (IDH) mutation has become one of the most important prognostic biomarkers in glioma management, indicating better treatment response and prognosis. IDH mutations confer neomorphic activity leading to conversion alpha-ketoglutarate (α-KG) 2-hydroxyglutarate (2HG). The purpose this study was investigate clinical potential proton MR spectroscopy (1H-MRS) identifying IDH-mutant gliomas by detecting characteristic resonances 2HG its complex interplay with...
A 56-year-old teetotaller man with hypertension and gout presented a week duration of painless worsening diplopia on background loss weight appetite, generalised lethargy weakness for 1 year. On examination, he was noted to be hypothermic tachycardic muscle wasting. Proximal myopathy, lower limb fasciculations areflexia, restricted bilateral eye abduction nystagmus were observed. Blood investigations demonstrated compensated lactic acidosis, acute kidney injury leucocytosis. nerve conduction...
Abstract Purpose Accurate prognostication may aid in the selection of patients who will benefit from surgery at recurrent WHO grade 4 glioma. This study aimed to evaluate role serial tumour volumetric measurements for first recurrence. Methods We retrospectively analyzed with histologically-diagnosed glioma initial and recurrence a tertiary hospital between May 2000 September 2018. performed auto-segmentation using ITK-SNAP software, followed by manual adjustment measure contrast-enhanced...
Motivation: Optimal treatment for GBM requires precise targeting of all viable tumor cells, many which are not visible on conventional neuroimaging. Goal(s): We aimed to utilize WBSI identify infiltrating cells in patients selecting a target volume personalized mapping transducer arrays enhanced delivery TTFields. Approach: A mean value choline/NAA was computed from normal mask, and voxels that exceeded two-fold threshold were included 3D-composite mask the region. Results: provided higher...
Background and Objectives The purpose of this study is to examine differences in image quality, discrepancy rates, productivity user experience between remote reporting over Virtual Application (VA) using visually calibrated monitors, diagnostic grade workstations hospital premises. Methods Three specialist accredited radiologists examined provisionally reported outpatient CT MR studies PACS delivered as a VA, monitors from their homes. They then proceeded view the same within premises issue...