A5037548707- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Influenza Virus Research Studies
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Cancer-related gene regulation
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Biosimilars and Bioanalytical Methods
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Redox biology and oxidative stress
- Glutathione Transferases and Polymorphisms
- Genomics and Chromatin Dynamics
- Histone Deacetylase Inhibitors Research
- Nitric Oxide and Endothelin Effects
- Genetic Syndromes and Imprinting
- Viral gastroenteritis research and epidemiology
- DNA and Nucleic Acid Chemistry
- Microtubule and mitosis dynamics
- RNA regulation and disease
Guangzhou HKUST Fok Ying Tung Research Institute
2024
CytomX Therapeutics (United States)
2015-2023
China Animal Disease Control Center
2021
Guangxi University
2021
Chang Gung University
2014-2015
R&D Systems (United States)
2006
Pfizer (United States)
2001-2002
University of Iowa
1997-2001
Abstract T cell–engaging bispecific antibodies (TCB) are highly potent therapeutics that can recruit and activate cytotoxic cells to stimulate an antitumor immune response. However, the development of TCBs against solid tumors has been limited by significant on-target toxicity normal tissues. Probody have developed as a novel class recombinant, protease-activated antibody prodrugs “masked” reduce antigen binding in healthy tissues but become conditionally unmasked proteases preferentially...
Skp1-cullin-F-box protein (SCF) is a multicomponent E3 ubiquitin (Ub) ligase that ubiquitinates number of important biologic molecules such as p27, β-catenin, and lκB for proteasomal degradation, thus regulating cell proliferation survival. One SCF component, SAG/ROC2/Rbx2/Hrt2, RING finger protein, was first identified redox-inducible which, when overexpressed, inhibited apoptosis both in vitro vivo. We report here sensitive to gene (SAG), well its family member ROC1/Rbxi, bound the...
Effective mosquito population suppression has been repeatedly demonstrated in field trials through the release of male mosquitoes to induce sterile mating with wild females using incompatible insect technique (IIT), (SIT), or their combination. However, upscaling these techniques requires a highly efficient and scalable approach for sex separation mass-reared minimize unintentional females, which can lead either replacement biting nuisance, major bottleneck up now. Here, we report successful...
Manganese superoxide dismutase (Mn-SOD) is a primary antioxidant enzyme whose expression essential for life in oxygen. Mn-SOD has tumor suppressor activity wide variety of tumors and transformed cell systems. Our initial observations revealed that was inversely correlated with AP-2 transcription factors normal human fibroblasts their SV-40 counterparts. Thus we hypothesized may down-regulate expression. To examine the functional role on promoter transactivation cotransfected AP-2-deficient...
Abstract Probody therapeutics (Pb-Txs) are conditionally activated antibody–drug conjugates (ADCs) designed to remain inactive until proteolytically in the tumor microenvironment, enabling safer targeting of antigens expressed both and normal tissue. Previous attempts target CD71, a highly antigen, have failed establish an acceptable therapeutic window due widespread tissue expression. This study evaluated whether probody–drug conjugate CD71 can demonstrate favorable efficacy tolerability...
Monte Carlo simulations are used to calculate the relative biological effectiveness (RBE) of 300 MeV u−1 carbon-ion beams at different depths in a cylindrical water phantom 10 cm radius and 30 long. RBE values for induction DNA double strand breaks (DSB), endpoint closely related cell inactivation, estimated monoenergetic energy-modulated carbon ion beams. Individual contributions from primary ions secondary nuclear fragments simulated separately. These based on multi-scale modelling...
Abstract T cell-engaging bispecific antibodies (TCBs) are highly potent therapeutics that direct the activity of cytotoxic cells to tumors. TCBs have shown clinical in hematologic malignancies, but development for solid tumor indications is proving more challenging. Due their high potency, can target normal tissues with low antigen expression, resulting significant on-target, off-tumor toxicity limit dosing levels. As a result, it has been difficult reach level drug exposure required...
Sensitive-to-apoptosis gene (SAG)/regulator of cullins (ROC)2/Rbx2/Hrt2 is a newly identified component SCF E3 ubiquitin ligase that controls cell-cycle progression by promoting ubiquitination and degradation inhibitors. We recently found SAG protects cells from apoptosis induced redox agents, promotes S-phase entry cell growth under serum starvation, required for yeast growth. In the present study, we report protein level was elevated in six 10 human colon carcinoma tissues (60%) as...
H9N2 subtype avian influenza A virus (AIV) is a causative agent that poses serious threats to both the poultry industry and global public health. In this study, we performed active surveillance identify AIVs from (chicken, duck, goose) environment of different regions in China, phylogenetically characterized sequences. AIV subtype-specific reverse transcription polymerase chain reaction (RT-PCR) showed 5.43% (83/1529) samples were positive, 87.02% (67/77) which AIVs. Phylogenetic analysis...
Reactive oxygen species have been shown to play important roles in v-Ha-Ras mitogenic signaling. We hypothesized that overexpression would induce superoxide production, and therefore modify expression of the primary antioxidant enzyme system. demonstrated immortal rat kidney epithelial cells stably transduced with constitutively active v-Ha-ras produced significantly larger amounts radical than wildtype or vector-transfected control cells. The levels enzymes copper- zinc-containing...
Activator protein-2 (AP-2) is a transcription factor with transactivating and transrepressing potential in different promoter contexts. AP-2 contains seven cysteines, its vitro DNA binding activity redox-sensitive. Superoxide dismutase-2 (SOD2), which encodes the antioxidant enzyme manganese superoxide dismutase (MnSOD), putative tumor suppressor gene whose loss of expression associated malignant phenotype. SOD2 mutations that generate new sites are MnSOD cancer cells. In current study, we...
Abstract Antibody drug conjugates (ADCs) have shown their greatest clinical utility when targeting antigens expressed at very high levels on cancer cells that coincidentally lower expression in normal tissues. This is exemplified by the approvals of trastuzumab emtansine for her2neu 3+ breast and brentuximab vedotin Hodgkins Disease Anaplastic large-cell lymphoma. Both drugs are approved subsets specific types where target antigen particularly relative to There other cell surface highly...
Abstract The targets of Antibody Drug Conjugates (ADCs) have typically been selected by identifying transmembrane antigens that are highly expressed in tumors but low or absent normal tissues. number potential ADC meeting these requirements is limited, either because expression not high enough for optimal efficacy, tissues too high, leading to toxicity. Probody (TM) therapeutics antibody prodrugs designed remain inactive until proteolytically activated the tumor microenvironment. technology...
Abstract ProbodyTM therapeutics are antibody prodrugs designed to remain largely inactive until proteolytically activated in the tumor microenvironment (TME), potentially enabling safer targeting of antigens that highly expressed both and normal tissue. CD71 (transferrin receptor) is an example ideal Probody Drug Conjugate (PDC) target, not only because it efficiently internalizes can deliver a cytotoxic payload intracellularly, but also at high levels many different types as well dividing...
<div>Abstract<p>T cell–engaging bispecific antibodies (TCB) are highly potent therapeutics that can recruit and activate cytotoxic T cells to stimulate an antitumor immune response. However, the development of TCBs against solid tumors has been limited by significant on-target toxicity normal tissues. Probody have developed as a novel class recombinant, protease-activated antibody prodrugs “masked” reduce antigen binding in healthy tissues but become conditionally unmasked...