A5064447916- Pancreatitis Pathology and Treatment
- Protease and Inhibitor Mechanisms
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Angiogenesis and VEGF in Cancer
- Blood Coagulation and Thrombosis Mechanisms
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Cardiac, Anesthesia and Surgical Outcomes
- Gastric Cancer Management and Outcomes
- Cell Adhesion Molecules Research
- Body Contouring and Surgery
- Breast Implant and Reconstruction
- Cancer, Hypoxia, and Metabolism
- LGBTQ Health, Identity, and Policy
- Venous Thromboembolism Diagnosis and Management
- Diversity and Career in Medicine
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Antiplatelet Therapy and Cardiovascular Diseases
- Gastroesophageal reflux and treatments
- Biliary and Gastrointestinal Fistulas
- T-cell and B-cell Immunology
- Esophageal and GI Pathology
- Anesthesia and Pain Management
Montefiore Medical Center
2011-2025
Albert Einstein College of Medicine
2011-2025
Icahn School of Medicine at Mount Sinai
2017-2025
Mount Sinai Hospital
2025
The Bronx Defenders
2022
Creative Commons
2022
Maimonides Medical Center
2015-2022
Mount Sinai Hospital
2017
Mount Sinai Health System
2015
West Virginia University
2011
Abstract Gelatinase A (MMP‐2), a matrix metalloproteinase (MMP) involved in tumor invasion and angiogenesis, is secreted as an inactive zymogen (proMMP‐2) activated by proteolytic cleavage. Here we report that polymorphonuclear neutrophil (PMN)‐derived elastase, cathepsin G, proteinase‐3 activate proMMP‐2 through mechanism requires membrane‐type 1 (MT1‐MMP) expression. Immunoprecipitation of human PMN‐conditioned medium with mixture antibodies to abolished activation, whereas individual were...
von Willebrand factor (vWF), a glycoprotein produced uniquely by endothelial cells and megakaryocytes, is routinely used to identify vessels in tissue sections. Vessel density tumor specimens, as determined immuno-histochemical staining for vWF or other cell markers, negative prognostic many solid tumors. heterogeneously distributed throughout the vasculature, transcriptional control response microenvironment being responsible local variations levels of vWF. Here, we report that fibroblast...
The expression of HLA class I molecules on tumor cells is vital for CD8+T cell recognition Ags. Loss Ag as a result defective beta 2-microglobulin genes has been described in melanoma cells. To further evaluate mechanisms escape, was compared 24 metastatic lines and 20 melanocyte strains by FACS analysis with use allele-specific mAbs. Total loss not noted; instead, two relatively common phenomena were identified: 1) A variable degree HLA-B Ags melanocytes; however, HLA-A consistently...
von Willebrand factor (vWF), a glycoprotein produced uniquely by endothelial cells and megakaryocytes, is routinely used to identify vessels in tissue sections. Vessel density tumor specimens, as determined immuno-histochemical staining for vWF or other cell markers, negative prognostic many solid tumors. heterogeneously distributed throughout the vasculature, transcriptional control response microenvironment being responsible local variations levels of vWF. Here, we report that fibroblast...
The ubiquitous parasite
Despite decreased operative mortality, pancreaticoduodenectomy (PD) remains a formidable operation with substantial morbidity. We have evaluated the influence of preoperative endoscopic biliary drainage (EBD) on morbidity after PD for malignant obstruction by retrospectively reviewing medical records 182 patients undergoing between April 1985 and August 1996. Of 52 study obstructive jaundice, 22 underwent EBD, 30 were not drained. Eighty-three excluded bilirubin levels less than 5 mg/dl, 43...
Cholecystokinin-cholescintigraphy (CCK-CS) provides a physiologic, noninvasive, and quantitative method for assessing gallbladder contraction calculation of ejection fraction (GBEF). At present, it is used most commonly to identify patients with suspected functional disorder. However, the methodology CCK infusion normal values differ markedly among imaging centers.This document represents consensus opinion an interdisciplinary panel that gathered assess current optimal performing CCK-CS in...
To compare outcomes, complications, and costs between endoscopic open surgical approaches in the management of craniosynostosis using a large national database. Retrospective cohort study. National Inpatient Sample database, including inpatient hospital discharge data from 2018 to 2021 across 48 states Washington, D.C. The present study included 1099 patients admitted with primary diagnosis craniosynostosis. Among them, 183 (16.6%) underwent surgery 916 (83.3%) surgery. Surgical...
Introduction “Food swamps” are areas with a high density of fast-food restaurants (unhealthy foods) relative to grocery stores (healthy foods). Patients in regions inequitable access healthy foods may have worsened surgical outcomes due suboptimal nutrition. The present study assesses complication rates breast reduction patients residing food swamp scores (FSSs). Methods An institutional retrospective review who underwent surgery between 2015 and 2023 was conducted. USDA Food Environment...
Background As the obesity epidemic continues to grow, symptomatic macromastia at earlier ages has become increasingly common. Objective The present study aims explore trends, risk factors, and postoperative complications in adolescent reduction mammaplasty (ARM) over an 11-year period. Methods American College of Surgeons National Surgical Quality Improvement Program–Pediatrics (NSQIP-P) was queried identify ARM cases between 2012–2022 patients 18 years or younger. Patient demographics,...
In this study we analyzed the human leukocyte antigen (HLA) pattern of North American Caucasian patients with metastatic melanoma as compared (NAC) population. We also investigated whether HLA type had an effect on their tolerance and response to interleukin-2 (IL-2)-based therapy. Four hundred twelve serologic phenotypes referred National Cancer Institute, Institutes Health, from February 1989 through December 1993 were collected by typing patient's peripheral blood lymphocytes....