A5018090685- Ion channel regulation and function
- Ion Transport and Channel Regulation
- Magnesium in Health and Disease
- Lipid Membrane Structure and Behavior
- Advanced biosensing and bioanalysis techniques
- Neonatal Respiratory Health Research
- Electrolyte and hormonal disorders
- Cardiac electrophysiology and arrhythmias
- Ion Channels and Receptors
- RNA Interference and Gene Delivery
- Thyroid Disorders and Treatments
- Neural dynamics and brain function
- Renal function and acid-base balance
- Retinal Development and Disorders
- Aquaculture Nutrition and Growth
- Regulation of Appetite and Obesity
- Aquaculture disease management and microbiota
- Neuroendocrine regulation and behavior
- Parathyroid Disorders and Treatments
- Face Recognition and Perception
- Invertebrate Immune Response Mechanisms
- Immune Response and Inflammation
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Electrochemical Analysis and Applications
South Valley University
2013-2024
King Saud University
2013
University of Tübingen
2002-2005
TH Bingen University of Applied Sciences
2002
ABSTRACT. Mineralocorticoids stimulate Na+ reabsorption and K+ secretion in principal cells of connecting tubule collecting duct. The involved ion channels are ENaC ROMK1, respectively. In Xenopus oocytes, the serum glucocorticoid-sensitive kinase SGK1 has been shown to increase activity by enhancing its abundance plasma membrane. With same method, ROMK1 appeared be insensitive regulation SGK1. On other hand, colocalize with NHERF2, a protein mediating targeting trafficking transport...
The epithelial Ca2+ channel TRPV5 (ECaC1) plays a key role in renal and intestinal (re)absorption is thus regulated by 1,25(OH) 2D3. present study aims to explore whether the serum glucocorticoid inducible kinase SGK1, transcriptionally upregulated To this end cRNA encoding has been injected into Xenopus oocytes with or without additional injection of its isoforms SGK2 SGK3, constitutively active S422DSGK1, inactive K127NSGK1, T308D,S473DPKB and/or Na+/H+ exchanger regulating factor NHERF2....
Renal calcium reabsorption involves the epithelial channel ECaC1 (TRPV5) which is tightly regulated by 1,25(OH)2D3. As shown recently, TRPV5 activated serum and glucocorticoid inducible kinase SGK1, a transcriptionally upregulated This stimulatory effect due to enhanced abundance in plasma membrane requires presence of scaffold protein NHERF2 (sodium hydrogen exchanger regulating factor 2). The present study aims define molecular requirements for interaction with SGK1 NHERF2. Pull-down...
Amelioration of hyperinsulinemia and insulin resistance associated with obesity is a cardinal target for therapeutics. Therefore, we investigated the relation Fibrilln-1 ( FBN1) mRNA expression hepatic phosphoenolpyruvate caboxykinase PEPCK ) enzyme to ameliorative impact oxytocin on obesity-induced diabetes, suggesting glycogenolysis markers in diabetic models. Four groups forty male Wistar rats were formed n = 10): control group fed basal diet intra peritoneal injections saline; an...
Abstract Objective During Egypt's hot summer season, Aeromonas veronii infection causes catastrophic mortality on Nile Tilapia Oreochromis niloticus farms. Egypt is ranked first in aquaculture production Africa, sixth worldwide, and third global tilapia production. This study aimed to investigate, at the molecular level, early innate immune responses of experimental A. infection. Methods The relative gene expression, co-expression clustering, correlation four selected genes were studied by...
Phosphatidylserine (PS) is a phospholipid that an important component of all cell membranes.Normally, PS only found on the cytosolic surface plasma membrane.Obligatory translocation from interior to exterior side membranes potential biomarker for apoptotic death.The SELEX technology (Systematic Evolution Ligands by Exponential enrichment) widely applied as in vitro selection and amplification method generate target-specific aptamers.In this study, entropic fragment based approach (EFBA) was...
The vertebrate retina is a part of the central nervous system (CNS) that can be visualized in non-invasive manner.The thin multi-layered sensory tissue neural cells contains millions photoreceptors.There are two physiologically distinct types photoreceptors across retina, cones and rods.The light sensitivity results from presence visual pigment molecules outer segment cone rod cells.All pigments composed components: retinal (vitamin A aldehyde), termed chromophore, bound to protein called...
Inorganic phosphate (Pi) is reabsorbed in the renal proximal convoluted tubules mainly via electrogenic sodium dependent cotransporter NaPi Type IIa (NaPi-IIa).The isoforms of NaPi-IIa have been cloned from different species such as rat (NaPi-2).Serum and glucocorticoid-induced kinase 1 (SGK1) (NaPi-2) are highly expressed brush border membrane (BBM) tubule cells.The significance regulation has, however, remained elusive.On other hand, carboxyl-terminal tail NaPi-2 contains information for...
Bacterial infection is one of the most common causes systemic inflammatory syndrome known as sepsis.Previous studies have been shown that sever sepsis was often complicated with secondary multiple organs dysfunction.This may greatly affect thyroid gland function leading to dysfunction.The objective this study elucidate effect bacterial endotoxin (lipopolysaccharide, LPS) on function.The extended investigate role L-arginine (L-Arg) immunomodulator in LPS-induced inflammation.Eighty adults,...