A5080772457- Alzheimer's disease research and treatments
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Parkinson's Disease Mechanisms and Treatments
- Neurological and metabolic disorders
- Diet and metabolism studies
- Platelet Disorders and Treatments
- Alcohol Consumption and Health Effects
- Diabetes Treatment and Management
- Neonatal Respiratory Health Research
- Neuroscience and Neuropharmacology Research
- Alcoholism and Thiamine Deficiency
- Dementia and Cognitive Impairment Research
- Neurological Disorders and Treatments
- Advanced Neuroimaging Techniques and Applications
- Blood groups and transfusion
- Prion Diseases and Protein Misfolding
- Cerebral Palsy and Movement Disorders
Helsinki University Hospital
2021-2023
University of Helsinki
2021-2023
University of Eastern Finland
2010
Kuopio University Hospital
2008-2009
A causative association between diabetes mellitus (DM) and Alzheimer's disease (AD) has been suggested based on clinical epidemiological studies. One hypothesis is that the link DM AD related to function of insulin-degrading enzyme (IDE), an degrades not only insulin pancreatic amylin but also beta-amyloid (Abeta). Thus, in diabetics, Abeta might compete for IDE this lead increase Abeta. The objective study was test hyperinsulinaemia can elevate levels thus contribute pathology...
Amyloid-β (Aβ) peptide, a cleavage product of the amyloid-β protein precursor (AβPP), has been reported to be detected in intracellular compartment. Most studies reporting presence Aβ are based on use immunohistochemis
Summary The ristocetin cofactor activity assay (VWF:RCo) is the reference method for assessing von Willebrand factor (VWF) but remains difficult to perform, and coefficient of variation high (about 20–30%). This study evaluated compared performance measuring VWF two newly commercialised assays [VWF:Ac Innovance (VWF:Ac) VWF:RCo Acustar (VWF:RCo Acu)] with aggregation in 123 pathological plasma samples. correlation concordance between both new tests (VWF:RCo-Acu VWF:Ac) were good. results...
The present study assessed beta-amyloid (Abeta) protein aggregates in postmortem human brains subjects who had experienced stroke to examine the proposed association between ischemic stress and accumulation of Abeta reported rodents.A sample 484 from nondemented subjects, lacking isocortical neurodegenerative pathology with verified cerebrovascular lesions, 57 age-matched controls were respect Abeta, Abeta40, Abeta42 cortex thalamus by immunohistochemical techniques.The load did not display...
Abstract Epidemiological studies have indicated that excessive alcohol consumption leads to cognitive impairment, but the specific pathological mechanism involved remains unknown. The present study evaluated association between heavy intake and neuropathological hallmark lesions of three most common neurodegenerative disorders, i.e., Alzheimer's disease (AD), dementia with Lewy bodies (DLB), vascular impairment (VCI), in post‐mortem human brains. cohort was sampled from subjects who...
<i>Background/Aims: </i>Abnormal processing of hyperphosphorylated τ (HPτ), amyloid-β (Aβ) and α-synuclein (αS) proteins is considered as causative with regard to the clinical symptoms in age-related neurodegenerative diseases. <i>Methods: </i>In this retrospective, postmortem study applying immunohistochemical methodology, we assessed Alzheimer’s-disease (AD)-related HPτ Aβ pathology 178 subjects αS pathology. <i>Results: </i>These pathologies were...
Cognitive development is characterized by the structural and functional maturation of brain. Diffusion-weighted magnetic resonance imaging (dMRI) provides methods investigating brain structure connectivity their correlations with neurocognitive outcome. Our aim was to examine relationship between early visual abilities, white matter structures, later
Objective: The aim of this study was to evaluate the ability neonatal neurobehavioral characteristics act as an indicator for later neurodevelopment and neurocognitive performance. Methods: Sixty-six infants born extremely preterm (&lt;28 gestational weeks) were followed until 6.5 years. Neurobehavior at term age assessed by behavior subscale Hammersmith Neonatal Neurological Examination (HNNE) using dichotomic rating, optimal, non-optimal. Griffiths Mental Developmental Scales (GMDS) 2...
Cognitive development is characterized by the structural and functional maturation of brain, a cascade where few basic abilities are foundation later cognition. Diffusion-weighted magnetic resonance imaging (dMRI) provides methods to investigate brain structure connectivity their correlations with neurocognitive outcome. Early visual important for development. Therefore, our aim was examine relationship between early abilities, white matter structures, outcome social cognition skills.This...