A5056826221- COVID-19 and Mental Health
- Alzheimer's disease research and treatments
- COVID-19 Pandemic Impacts
- Workplace Health and Well-being
- Cancer Immunotherapy and Biomarkers
- Employment and Welfare Studies
- Cholinesterase and Neurodegenerative Diseases
- Infection Control and Ventilation
- Immune Cell Function and Interaction
- Health disparities and outcomes
- Gut microbiota and health
- COVID-19 epidemiological studies
- Drug Transport and Resistance Mechanisms
- Work-Family Balance Challenges
- Dialysis and Renal Disease Management
- CAR-T cell therapy research
- Endoplasmic Reticulum Stress and Disease
- Vaccine Coverage and Hesitancy
- Long-Term Effects of COVID-19
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Healthcare professionals’ stress and burnout
- Parasites and Host Interactions
- COVID-19 and healthcare impacts
- Pancreatic function and diabetes
Showa University
2016-2025
University of Occupational and Environmental Health Japan
2013-2024
Juntendo University
2024
Chitose Institute of Science and Technology
2024
Hitachi (Japan)
2023
Ministry of Health Labour and Welfare
2021-2023
Neami National
2022
ANDI
2021-2022
DMG Mori (Japan)
2021-2022
Noguchi Hospital
2021
Dietary fibers are metabolized by gastrointestinal (GI) bacteria into short-chain fatty acids (SCFAs). We investigated the potential role of these SCFAs in β-amyloid (Aβ) mediated pathological processes that play key roles Alzheimer's disease (AD) pathogenesis.Multiple complementary assays were used to investigate individual for their dose-responsive effects interfering with assembly Aβß1-40 and Aβ1-42 peptides soluble neurotoxic Aβ aggregates.We found several select capable potently...
The ever-changing social implications of the COVID-19 pandemic have resulted in an urgent need to understand working environments and health status workers. We conducted a nationwide Internet-based survey Japanese workers December 2020, midst country's "third wave" infection. Of 33,087 surveys collected, 6,051 were determined invalid responses. 27,036 included study balanced terms geographical area, sex participants, type work, according sampling plan. Men more likely than women...
Amyloid β-protein (Aβ) molecules tend to aggregate and subsequently form low MW (LMW) oligomers, high (HMW) aggregates such as protofibrils, ultimately fibrils. These Aβ species can generally amyloid plaques implicated in the neurodegeneration of Alzheimer disease (AD), but therapies designed reduce plaque load have not demonstrated clinical efficacy. Recent evidence implicates oligomers AD neuropathology, precise mechanisms are uncertain. We examined neuronal dysfunction from HMW-Aβ1-42...
There is an urgent need to establish blood biomarkers for Alzheimer's disease (AD). Although it has been speculated that brain-derived neurotrophic factor (BDNF) associated with AD, whether can be used as a biomarker yet determined. We serum, cerebrospinal fluid (CSF), and medial temporal lobe atrophy from patients AD evaluate the association of BDNF assess its severity. For analysis, 66 participants [21 normal controls (NCs) cognitive function, 22 mild impairment (MCI) due 23 AD] were...
Lymphoma-associated hemophagocytic syndrome (LAHS), which is the major subtype of adult-onset secondary lymphohistiocytosis (HLH), has a poor outcome. Although early diagnosis and treatment LAHS contributes to better outcome, lack mass formation absence distinct lymph node enlargement often delay underlying lymphoma. A recent study, statistically analyzed HLH cases in literature, showed that serum soluble interleukin-2 receptor (sIL-2R)/ferritin ratio could be used as marker LAHS. To verify...
Immune checkpoint inhibitors have had a major impact on cancer treatment. Gut microbiota plays role in the microenvironment, affecting treatment response. The gut is highly individual, and varies with factors, such as age race. composition Japanese patients efficacy of immunotherapy remain unknown.We investigated 26 solid tumors prior to immune inhibitor monotherapy identify bacteria involved these drugs immune-related adverse events (irAEs).The genera Prevotella Parabacteroides were...
Abstract The low response rate of immune checkpoint inhibitors (ICIs) is a challenge. efficacy ICIs influenced by the tumour microenvironment, which controlled gut microbiota. In particular, intestinal bacteria and their metabolites, such as short chain fatty acids (SCFAs), are important regulators cancer immunity; however, our knowledge on effects individual SCFAs remains limited. Here, we show that isobutyric acid has strongest effect among both activity growth. vitro, cell numbers were...
Alzheimer's disease (AD) is a slowly progressive form of dementia, characterized by memory impairment and cognitive dysfunction. AD mainly the deposition amyloid β (Aβ) plaques intracellular neurofibrillary tangles in brain, along with neuronal degeneration high levels oxidative stress. Cilostazol (CSZ) was recently found to suppress progression decline patients stable receiving acetylcholinesterase inhibitors. This present study aimed clarify mechanism which CSZ protects neurons from...
The work system reform and the COVID-19 pandemic in Japan have prompted efforts toward telecommuting Japan. However, only a few studies investigated stress health effects of telecommuting. Therefore, this study aimed to clarify relationship between job among Japanese workers.This was cross-sectional study. In December 2020, during "third wave" pandemic, an Internet-based nationwide survey 33 087 workers (The Collaborative Online Research on Novel-coronavirus Work, CORoNaWork study)...
Alzheimer's disease (AD) is the most common cause of dementia. The cardinal neuropathological characteristic AD accumulation amyloid-β (Aβ) into extracellular plaques that ultimately disrupt neuronal function and lead to neurodegeneration. One possible therapeutic strategy therefore prevent Aβ aggregation. Previous studies have suggested vitamin E analogs slow progression in humans. In present study, we investigated effects tocotrienol-rich fraction (TRF), a mixture from palm oil, on amyloid...
Abstract Inflammation and glycemic control are important prognosis‐related factors for hemodialysis ( HD ) patients; moreover, inflammation affects insulin secretion. Here, we evaluated the anti‐inflammatory effects of monotherapy with linagliptin—a dipeptidase‐4 inhibitor—in patients type 2 diabetes. We examined 21 diabetic who were not receiving oral diabetes drugs or therapy poor (glycated albumin [ GA ] level, >20%). Linagliptin (5 mg) was administered to daily. The levels...
Accumulating evidence have shown the association of Parkinson's disease (PD) with osteoporosis. Bone loss in PD patients, considered to be multifactorial and a result motor disfunction, is hallmark symptom that causes immobility decreased muscle strength, as well malnutrition medication. However, no known experimental has been presented showing deleterious effects anti-PD drugs on bone or involvement dopaminergic degeneration metabolism. Here, we show osteoporosis associated caused by...
Abstract The ever-changing social implications of the COVID-19 pandemic have resulted in an urgent need to understand working environments and health status workers. We conducted a nationwide Internet-based survey Japanese workers December 2020, midst country’s “third wave” infection. Of 33,087 surveys collected, 6,051 were determined invalid responses. 27,036 included study balanced terms geographical area, participant sex, type work, according sampling plan. Men more likely than women...
Objective: The present study examined the relationship between intensity of home-based telework and work engagement. Methods: This cross-sectional using a self-administrated questionnaire survey was conducted from December 22 to 25, 2020, in Japan. subjects were asked single-item questions about three-item engagement Utrecht Work Engagement Scale. Coefficients estimated multilevel regression model nested by prefecture residence adjusted for covariates. Results: High-intensity (4 or more days...
Immune checkpoint inhibitors (ICIs) confer remarkable therapeutic benefits to patients with various cancers. However, many are non-responders or develop resistance following an initial response ICIs. There no reliable biomarkers predict the effect of Therefore, this study investigated clinical implications plasma levels soluble anti-programmed death-1 (sPD-1) in cancer treated In total, 22 (13 non-small-cell lung carcinoma, 8 gastric cancer, and 1 bladder cancer) were evaluated for sPD-1...
To examine how the mismatch between telecommuting preference and frequency was associated with psychological distress during COVID-19 pandemic.Data from 33,302 workers throughout Japan were obtained using an Internet survey. Among participants, 20,395 who telecommuted included in analysis. Participants' pandemic determined a questionnaire. Psychological assessed Kessler 6 (K6).Among participants did not prefer to telecommute, those four or more days per week had OR of 0.67 (P < 0.001) 1.87 =...
Amyloid-β (Aβ) aggregation intermediates, including oligomers and protofibrils (PFs), have attracted attention as neurotoxic aggregates in Alzheimer's disease. However, due to the complexity of pathway, structural dynamics intermediates how drugs act on them not been clarified. Here we used high-speed atomic force microscopy observe Aβ42 PF at single-molecule level effect lecanemab, an anti-Aβ antibody with positive results from Phase 3 Clarity AD. was found be a curved nodal structure...
Abstract: Background Pneumonia caused by Stenotrophomonas maltophilia is rare, but can be lethal in severely immunocompromised patients. However, its clinical course remains unclear. Patients and methods with pneumonia S. Toranomon Hospital (890 beds, Tokyo, Japan) were reviewed retrospectively between April 2006 March 2010. Results During the study period, 10 cases of identified. Seven patients had acute myeloid leukemia, 2 myelodysplastic syndrome, 1 malignant lymphoma. All developed...
Although gender stereotypes regarding paid work and unpaid are changing, most wives responsible for taking care of the family home in Japan. It is unclear how time spent on housework childcare has changed between working men women during COVID-19 pandemic The purpose this study to investigate women's responsibilities Japan depending hours, job type, number employees workplace, frequency telecommuting.A cross-sectional analysis (N = 14,454) was conducted using data from an Internet monitoring...
Abstract Immune checkpoint inhibitor discovery represents a turning point in cancer treatment. However, the response rates of solid tumors remain ~10%–30%; consequently, prognostic and immune‐related adverse event (irAE) predictors are being explored. The programmed cell death protein 1 (PD‐1) receptor occupancy (RO) PD‐1 inhibitors depends on number peripheral blood lymphocytes their expression levels, suggesting that RO may be related to efficacy events. As inhibition affects each T‐cell...
Abstract Background Recently, intestinal bacteria have attracted attention as factors affecting the prognosis of patients with cancer. However, microbiome is composed several hundred types bacteria, necessitating development an analytical method that can allow use this information a highly accurate biomarker. In study, we investigated whether preoperative bacterial profile in esophageal cancer who underwent surgery after chemotherapy could be used biomarker postoperative recurrence Methods...