A5056909963- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Plant Molecular Biology Research
- Ubiquitin and proteasome pathways
- Chromosomal and Genetic Variations
University of California, San Francisco
2022-2025
Unlike other chromatin remodelers, INO80 preferentially mobilizes hexasomes, which can form during transcription. Why prefers hexasomes over nucleosomes remains unclear. Here, we report structures of
Abstract Aberrant chromatin is expanding as a new class of disease and resistance driver for multiple pathologies. While billions dollars have been poured into drugging regulatory factors, the toxicity previous approaches limits potential promise. Conventional drug discovery strategies focused on targeting only stable interfaces regulators. However, specific regulation function occurs in large part from unstructured intrinsically disordered regions (IDRs). IDRs help specify functionality...
Chromatin states define cell fates and consequently dysfunctional chromatin drive disease. Conventional approaches to target typically rely on targeting a defined, structured binding pocket of specific protein. However, drugs developed from single proteins have often failed in the clinic due toxicity broad non-specific effects genome. Substantial previous work has indicated that function given state is encoded context-dependent protein-protein interactions (PPIs) between Intrinsically...