A5080662071- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Quinazolinone synthesis and applications
- Synthesis and Catalytic Reactions
- Fluorine in Organic Chemistry
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Protein Degradation and Inhibitors
- Catalytic C–H Functionalization Methods
- Ubiquitin and proteasome pathways
- Chemical Synthesis and Reactions
- Advanced Synthetic Organic Chemistry
- Analytical Chemistry and Chromatography
- Multiple Myeloma Research and Treatments
- Phytochemical compounds biological activities
- Bioactive Compounds and Antitumor Agents
- Toxin Mechanisms and Immunotoxins
- Catalytic Cross-Coupling Reactions
- Synthesis of heterocyclic compounds
- Beetle Biology and Toxicology Studies
- Chemical synthesis and alkaloids
- Genetics and Neurodevelopmental Disorders
Lake Superior State University
2016-2024
Michigan State University
2007-2013
University of Pittsburgh
2012
Eastern Michigan University
2008
Northern Michigan University
2008
A hypervalent iodine(III)-mediated cross-dehydrogenative coupling reaction for the direct formation of C–C, C–N, and C–O bonds in dihydroquinazolines has been developed. This one-pot method allows synthesis C4-disubstituted as well C4-spirolactam, spirolactone, spiroindene moderate to high yields.
The proteasome has emerged as the primary target for treatment of multiple myeloma. Unfortunately, nearly all patients develop resistance to competitive-type inhibitors such bortezomib. Herein, we describe optimization noncompetitive yield derivatives that exhibit nanomolar potency (compound 49, IC50 130 nM) toward inhibition and overcome bortezomib resistance. These studies illustrate feasibility development additives and/or alternatives competitive inhibitors.
A series of α-alkoxy carbamates that cleave under mild conditions to release alcohols has been synthesized through a multicomponent process. The relationship between structural features in these compounds and the rate alcohol presence basic hydrogen peroxide studied. preparation other demonstrated.
A triflic anhydride mediated one-pot tandem reaction involving a Pictet–Spengler-like annulation step has been developed for the synthesis of 3,4-dihydroquinazolines.
tert-Alkyl amino hydroxy carboxylic acids are abundantly present within the structure of many biologically active natural products. We describe herein synthesis these substrates using an oxazolone-mediated ene-type reaction with enol ethers followed by NaBH4 reduction intermediate oxazolone.
A multicomponent tandem assembly procedure for the synthesis of diverse C4-quaternary 3,4-dihydroquinazolines from amides, amines, and ketones has been developed. The one-pot reaction involves successive triflic anhydride mediated amide dehydration, ketimine addition, Pictet–Spengler-like cyclization processes affords products in up to 92% yield. Conversion corresponding 1,4-dihydroquinazolines via a two-step N1 dealkylation regioselective N3 functionalization protocol, including...
A hypervalent iodine(III)-mediated C(sp
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access Abstract, please click on HTML or PDF.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”