A5056770975- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Planarian Biology and Electrostimulation
- EEG and Brain-Computer Interfaces
- Pancreatic function and diabetes
- Epilepsy research and treatment
- Diabetes and associated disorders
- Diabetes Management and Research
- Functional Brain Connectivity Studies
- Biomedical Ethics and Regulation
- Diabetic Foot Ulcer Assessment and Management
- Mitochondrial Function and Pathology
- Autism Spectrum Disorder Research
- Ion channel regulation and function
- Infrared Thermography in Medicine
- Lipid Membrane Structure and Behavior
- 3D Printing in Biomedical Research
Royan Institute
2019-2024
Academic Center for Education, Culture and Research
2019-2024
Montreal Neurological Institute and Hospital
2014-2023
McGill University
2015-2019
Ahvaz Jundishapur University of Medical Sciences
2019
Payame Noor University
2017
Seizures in temporal lobe epilepsy can be classified as hypersynchronous and low-voltage fast according to their onset patterns. Experimental evidence suggests that fast-onset seizures mainly result from the synchronous activity of γ-aminobutyric acid-releasing cells. In this study, we tested hypothesis using optogenetic control parvalbumin-positive interneurons entorhinal cortex, vitro 4-aminopyridine model. We found both spontaneous optogenetically induced had similar addition, types...
Objective Ictal events occurring in temporal lobe epilepsy patients and experimental models mimicking this neurological disorder can be classified, based on their onset pattern, into low‐voltage, fast versus hypersynchronous seizures. It has been suggested that the pattern is mainly contributed by interneuronal (γ‐aminobutyric acidergic) signaling, whereas involves activation of principal (glutamatergic) cells. Methods Here, we tested hypothesis using optogenetic control parvalbumin‐positive...
Despite many advances made in understanding the pathophysiology of epileptic disorders, seizures remain poorly controlled approximately one-third patients with mesial temporal lobe epilepsy. Here, we established efficacy cell type-specific low-frequency stimulation (LFS) controlling ictogenesis mouse entorhinal cortex (EC) an vitro brain slice preparation. Specifically, used 1 Hz optogenetic calcium/calmodulin-dependent protein kinase II-positive principal cells as well parvalbumin- or...
Objective To establish the effects induced by long‐term, unilateral stimulation of parvalbumin (PV)‐positive interneurons on seizures, interictal spikes, and high‐frequency oscillations (80–500Hz) occurring after pilocarpine‐induced status epilepticus (SE)—a proven model mesial temporal lobe epilepsy (MTLE)—in transgenic mice expressing or not ChR2. Methods PV‐ChR2 (n = 6) PV‐Cre were treated with pilocarpine to induce SE. Three hours SE onset, optogenetic (450nm, 25mW, 20‐millisecond pulses...
A balance between excitation and inhibition is required to maintain stable brain network dynamics. Traditionally, seizure activity believed arise from the breakdown of this delicate in favor with loss inhibition. Surprisingly, recent experimental evidence suggests that conventional view may be untrue, plays a prominent role development epileptiform synchronization. Here, we explored co-transporter KCC2 onset inhibitory network-induced seizures. Our experiments acute mouse slices either sex...