A5003319986- Genetics, Aging, and Longevity in Model Organisms
- Cellular transport and secretion
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Bone health and treatments
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Zebrafish Biomedical Research Applications
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- ATP Synthase and ATPases Research
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Cellular Mechanics and Interactions
- Spaceflight effects on biology
- 3D Printing in Biomedical Research
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Circular RNAs in diseases
Institute of Medical Biology
2009-2018
Stanford University
2013-2014
Howard Hughes Medical Institute
2012-2014
University of Wisconsin–Madison
2006
Highland Community College - Illinois
2006
AbstractMicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression at the posttranscriptional level. Research on miRNAs has highlighted their importance in neural development, but specific functions neurally enriched remain poorly understood. We report here profile during neuronal differentiation human neuroblastoma cell line SH-SY5Y. Six were significantly upregulated induced by all-trans-retinoic acid and brain-derived neurotrophic factor. demonstrated ectopic...
Calcium/calmodulin-dependent protein kinase II (CAMK2) plays fundamental roles in synaptic plasticity that underlies learning and memory. Here, we describe a new recessive neurodevelopmental syndrome with global developmental delay, seizures intellectual disability. Using linkage analysis exome sequencing, found this disease maps to chromosome 5q31.1-q34 is caused by biallelic germline mutation CAMK2A . The missense mutation, p.His477Tyr located the association domain critical for its...
Understanding molecular targets and developing novel imaging agents can improve early cancer detection. Radioiodinated NM404, a phospholipid ether analog in clinical trials, displays selective prolonged retention 28/28 xenograft spontaneous tumor models. This specificity for malignant tumors is apparently due to of NM404 cells having reduced ability metabolize NM404. Prior vitro studies implicate phospholipase D (PLD) metabolism. PLD critical regulator cell proliferation, survival signaling,...