A5083470929- Computational Fluid Dynamics and Aerodynamics
- Aerospace and Aviation Technology
- Air Traffic Management and Optimization
- Advanced Aircraft Design and Technologies
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Thyroid Disorders and Treatments
- Antimicrobial Resistance in Staphylococcus
- Cancer Treatment and Pharmacology
- Bacterial Identification and Susceptibility Testing
- Protein Tyrosine Phosphatases
- Ion channel regulation and function
- RNA regulation and disease
- Neonatal Respiratory Health Research
- Neurological disorders and treatments
- Climate Change and Health Impacts
- Birth, Development, and Health
- HIV/AIDS drug development and treatment
- Aerospace Engineering and Control Systems
- Bacterial biofilms and quorum sensing
- Participatory Visual Research Methods
- Autophagy in Disease and Therapy
- Fatty Acid Research and Health
- Synthesis of Organic Compounds
- Advanced Combustion Engine Technologies
Langley Research Center
2019-2024
Griffith University
2019-2023
University of Oklahoma
2018-2019
Unisys (United States)
2012-2018
Queensland University of Technology
2018
University of Michigan
2009-2010
Wayne State University
2003
Workplace health interventions incorporating qualitative and quantitative components (mixed methods) within a Participatory Action Research approach can increase understanding of contextual issues ensuring realistic which influence behaviour. Mixed methods research teams, however, face variety challenges at the methodological expertise levels when designing actions interventions. Addressing these improve team's functionality lead to higher quality outcomes. In this paper we reflect on data...
Iodide is an essential constituent of milk that present in concentrations more than order magnitude higher the maternal plasma. Earlier, a sodium-iodide symporter was identified mammary gland; this transporter presumed to take iodide from plasma into alveolar epithelial cells gland. We now report existence second transporter, pendrin, which also for accumulation milk. Via Western blotting methods, high levels were detected lactating tissues; lesser amounts found tissues midpregnant and...
Flight test and modeling techniques were developed for efficiently identifying global aerodynamic models that can be used to accurately simulate stall, upset, recovery on large transport airplanes. The validated in a high-fidelity fixed-base flight simulator using wind-tunnel database, realistic sensor characteristics, deck representative of aircraft. Results demonstrated identified rapidly relatively simple piloted maneuvers. Stall maneuver predictions comparisons with data from the...
Abstract Staphylococcus epidermidis is one of the most prevalent prokaryotic species on human skin and mucosal membranes that constitute commensal flora. S. has become common causes primary bacteremia. Infections are difficult to diagnose because pathogen natural niches ability adhere inanimate surfaces via biofilms. Alarmingly, acquired resistance many antibiotics, which presents a danger health. Known as methicillin‐resistant (MRSE), clinical isolates MRSE in North America exhibit β‐lactam...
Linoleic acid consumption is increasing in Western populations. We investigated whether elevated linoleic pregnancy was deleterious to mothers or offspring. Maternal and fetal body organ weights were not affected by consumption. lipids leptin altered following Male offspring numbers reduced consumption.Dietary intakes of (LA) have increased dramatically populations, including women reproductive age. Pro-inflammatory effects LA may detrimental on maternal outcomes. aimed investigate a diet...
With its high morbidity rate and increasing resistance to treatment, methicillin-resistant Staphylococcus aureus (MRSA) is a grave concern in the medical field. In methicillin-susceptible strains, β-lactam antibiotics disable penicillin binding proteins (PBPs) that cross-link bacterial cell wall. However, strains have PBP2a PBP4, which continue enzymatic activity presence of antibiotics. The PBP4 linked wall teichoic acid (WTA); thus, WTA has emerged as target for antibiotic drug discovery....
A study was undertaken at NASA Langley Research Center to establish, demonstrate, and apply methodology for modeling implementing the aerodynamic effects of MANPADS damage a transport aircraft into real-time flight simulation, demonstrate preliminary capability using such simulation conduct an assessment survivability. Key findings from this include: superpositioning incremental characteristics baseline model proved be simple effective way effects; primary effect wing rolling moment...
A preliminary simulation of a generic T-tail transport airplane configuration has been developed at the National Aeronautics and Space Administration Langley Research Center. The primary purpose this piloted is to assess aerodynamic model fidelity requirements for training airline pilots recognize recover from full-stall flight conditions in airplane. As result, significant flexibility designed into dynamics model. based on newly acquired static dynamic stability control data sources that...
Previous studies have shown that iodide is actively taken up into mammary alveolar epithelial cells and secreted milk. In the present we demonstrate 125 I also accumulates in MCF-7 against a concentration gradient; distribution ratios of greater than 30 were achieved. Iodide uptake transient, with peak accumulations occurring about 5 min. The rapidly metabolized, probably to iodine, it then exits cells. transporter identified pendrin. DIDS, nonspecific inhibitor anion exchange, inhibits...
NASA is conducting trade studies for a new hybrid-electric aircraft concept called the Subsonic Single Aft Engine (SUSAN) Electrofan. The SUSAN airplane being designed as 180-passenger commercial and expected to fly in 2040 time frame. flight deck of envisioned resemble typical two person flightcrew transport. Pilot control research issues include interfaces display state elements needed 17 engine propulsion system. A pilot study was conducted where one, two, three throttle handles were...
A piloted simulation study was performed in the Cockpit Motion Facility at National Aeronautics and Space Administration Langley Research Center. The research motivated by desire to reduce commercial transport airplane fatal accident rate due in-flight loss of control. purpose this study, which focused on a generic T-tail airplane, assess pilot sensitivity flight dynamics model formulation used during simulator stall recognition recovery training/demonstration profile. To accomplish this,...
Abstract Purpose Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. It generally diagnosed clinically after irreversible loss of dopaminergic neurons and no general biomarkers currently exist. To gain insight into underlying cellular causes PD we aimed to quantify proteomic differences between healthy control patient cells. Experimental Design Sequential Window Acquisition all THeoretical Mass Spectra was performed on primary cells from controls patients....
The genetic study of multi-incident families is a powerful tool to investigate contributions the development Parkinson’s disease. In this study, we identified rare PTPRA p.R223W variant as one three putative factors potentially contributing disease in an Australian family with incomplete penetrance. Whole exome sequencing these mutations affected cousins. missense was predicted be damaging and absent from 3,842 alleles PD cases. Overexpression wild-type RPTPα R223W mutant HEK293T cells that...