A5040116480- Tracheal and airway disorders
- Planarian Biology and Electrostimulation
- Marine Ecology and Invasive Species
- Plant and Biological Electrophysiology Studies
- Congenital heart defects research
- Congenital Ear and Nasal Anomalies
Stowers Institute for Medical Research
2021-2024
Neurocristopathies such as CHARGE syndrome result from aberrant neural crest development. A large proportion of cases are attributed to pathogenic variants in the gene encoding CHD7, chromodomain helicase DNA binding protein 7, which remodels chromatin. While role for CHD7 development is well documented, how this factor specifically up-regulated cells not understood. Here, we use epigenomic profiling chick and human identify a cohort enhancers regulating Chd7 expression other tissues. We...
Abstract Hox genes are highly conserved transcription factors renowned for their roles in the segmental patterning of embryonic anterior-posterior (A/P) axis. We report functions A/P tissue segmentation and transverse fission behavior underlying asexual reproduction adult planarian flatworms, Schmidtea mediterranea . Silencing each family members identifies 5 required reproduction. Among these, silencing hox3 results supernumerary segments, while post2b eliminates altogether. The opposing...