A5006581795- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Cellular Mechanics and Interactions
- CAR-T cell therapy research
- Advanced Photocatalysis Techniques
- Immune Cell Function and Interaction
- Ocular Diseases and Behçet’s Syndrome
- Hydrogels: synthesis, properties, applications
- Micro and Nano Robotics
- 3D Printing in Biomedical Research
- Catalytic Processes in Materials Science
- Neuroinflammation and Neurodegeneration Mechanisms
- Phagocytosis and Immune Regulation
- Lanthanide and Transition Metal Complexes
- Cell Adhesion Molecules Research
- Glioma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Pain Mechanisms and Treatments
- Electrocatalysts for Energy Conversion
Institute for Basic Science
2019-2023
Seoul National University
2019-2023
Seoul Institute
2019
Government of the Republic of Korea
2019
An urgent need in chemodynamic therapy (CDT) is to achieve high Fenton catalytic efficiency at small doses of CDT agents. However, simple general promotion the reaction increases risk damaging normal cells along with cancer cells. Therefore, a tailored strategy selectively enhance reactivity tumors, for example, by taking advantage characteristics tumor microenvironment (TME), demand. Herein, heterogeneous system based on copper–iron peroxide nanoparticles (CFp NPs) designed TME-mediated...
Abstract Chimeric antigen receptor‐T (CAR‐T) cell immunotherapy has shown impressive clinical outcomes for hematologic malignancies. However, its broader applications are challenged due to complex ex vivo cell‐manufacturing procedures and low therapeutic efficacy against solid tumors. The limited effects partially CAR‐T infiltration tumors inactivation of cells by the immunosuppressive tumor microenvironment. Here, a facile approach is presented in program macrophages, which can...
Postsurgical treatment of glioblastoma multiforme (GBM) by systemic chemotherapy and radiotherapy is often inefficient. Tumor cells infiltrating deeply into the brain parenchyma are significant obstacles to eradication GBM. Here, we present a potential solution this challenge introducing an injectable thermoresponsive hydrogel nanocomposite. As liquid that contains drug-loaded micelles water-dispersible ferrimagnetic iron oxide nanocubes (wFIONs), nanocomposite injected resected tumor site...
The receptor–ligand interactions in cells are dynamically regulated by modulation of the ligand accessibility. In this study, we utilize size-tunable magnetic nanoparticle aggregates ordered at both nanometer and atomic scales. We flexibly anchor tunable sizes over cell-adhesive RGD (Arg-Gly-Asp)-active material surface while maintaining density dispersed ligands accessible to macrophages constant. Lowering dispersity increasing aggregate size constant facilitates binding integrin receptors...
Neuropathic pain is a chronic and pathological caused by injury or dysfunction in the nervous system. Pro-inflammatory microglial activation with aberrant reactive oxygen species (ROS) generation spinal cord plays critical role development of neuropathic pain. However, efficacy current therapeutic methods for limited because only neurons neural circuits involved transmission are targeted. Here, an effective strategy to treat hypersensitivity using microglia-targeting ceria-zirconia...
In native microenvironment, diverse physical barriers exist to dynamically modulate stem cell recruitment and differentiation for tissue repair. this study, nanoassembly-based magnetic screens of various sizes are utilized, they elastically tethered over an RGD ligand (cell-adhesive motif)-presenting material surface generate nanogaps between the RGDs without modulating density. Large exhibiting low distribution stimulate integrin clustering facilitate focal adhesion, mechanotransduction,...
Sustainable energy-conversion and chemical-production require catalysts with high activity, durability, product-selectivity. Metal/oxide hybrid structure has been intensively investigated to achieve promising catalytic performance, especially in neutral or alkaline electrocatalysis where water dissociation is promoted near the oxide surface for (de)protonation of intermediates. Although promise demonstrated, it still challenging precisely modulate metal/oxide interfacial interactions on...