A5082524196- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- 3D Printing in Biomedical Research
- Photoreceptor and optogenetics research
- Acute Myeloid Leukemia Research
- Neuroscience and Neural Engineering
- Immune Cell Function and Interaction
- Retinal Development and Disorders
- Hematopoietic Stem Cell Transplantation
Johns Hopkins University
2021
Center for Life Sciences
2019
Peking University
2019
The limited number of human hematopoietic stem cells (HSCs) has restrained their widespread clinical application. Despite great efforts in recent years, the vitro expansion HSCs remains a challenge due to incomplete understanding signaling networks underlying HSC self-renewal. Here, we show that culturing cord blood (CB) CD34+ with JNK-IN-8, an inhibitor JNK pathway, can enhance self-renewal 3.88-fold increase cell number. These cultured repopulated recipient mice for 21 weeks and form...