Bronchial asthma (BA) and allergic diseases such as rhinitis (AR) atopic dermatitis (AtD) are the most common chronic diseases, prevalence of which is growing among child population with urbanization industrialization society. These place a heavy burden on patients, their families society whole, associated course, frequent exacerbations need for long-term therapy these diseases. Traditionally, data BA children based results program «International Study Asthma Allergies in Childhood», focused...

Information on the prevalence of allergic and non-allergic bronchial asthma among children preschool age is limited due to insufficient amount studies. At same time, determining phenotype disease key choosing optimal therapy prognosis. The objective: establish in 3–6 years living urban areas Altai Territory, study sensitization spectrum. authors conducted a momentary population-based study, consisting two stages. screening stage, included 3205 attending educational institutions. Symptoms...

Background. It is difficult to diagnose bronchial asthma (BA) in children under the age of 6 due limited ability study respiratory function. Therefore, it relevant search for such diagnostic markers BA that do not require active participation a child. Objective. Our aim was assess value serum periostin levels comparison with surrogate eosinophilic inflammation (total IgE and blood eosinophils) diagnosis preschool children. Methods. A cross-sectional included 3–6 years healthy peers. The...

The aim of the trial was to study prevalence and clinical allergic characteristics rhinitis (AR) bronchial asthma (BA) in urban preschool children. Materials methods research: a one-minute carried out on an sample 3–6 year olds (n=3205), consisting 2 stages – screening clinical. AR BA symptoms at stage by questioning parents using ISAAC questionnaire. At stage, diagnosis verified based diagnostic criteria ARIA (2008 revision) GINA (updated 2017) documents. skin prick testing with extracts...

Objective. To study predictors of bronchial asthma development in children 3-4 years old with recurrent broncho-obstructive syndrome by 5-6 age. Material and methods. The authors conducted a prospective cohort 2018-2020 the participation 61 aged 3–4 syndrome. Inclusion criteria: age years; ≥ 3 episodes past 12 months; informed voluntary consent. At first visit scientists determined levels serum periostin, specific inhalation allergens IgE, total IgE number eosinophils blood. In 24 months, at...

Background . The association between the vitamin D provision for children and atopic dermatitis (AD) development severity is not clearly determined. Objective aim of study was to compare 25(OH)D serum concentration in with AD healthy peers analysis disease allergen sensibilization. Methods included aged from 3 6 years their peers. Vitamin estimated via determined by chemiluminescent microparticle immunoassay. deficiency established at 20 ng/ml, insufficiency — 21–29 ng/ml. Sensibilization...

Background . Atopic dermatitis (AD) is an allergodermathosis that widespread in children and adult populations. Sensibilization to food allergens prevails of early age, airborne older age. Impairments skin barrier lead increase Staphylococcus aureus colonization finally aggravate the course AD sensibilization level. Objective. The aim study estimate spectrum 3-6 years old with its correlation severity. Methods. It was cross sectional two independent cohorts without (healthy) AD. Estimation...

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Sensitization spectrum in pre-school children with asthma and/or rhinitis remains unclear. Objective. Our aim was to estimate the allergen sensitization preschool living urban environment of Altai region rhinitis. Materials and methods. A cross-sectional survey performed 182 aged from 3 6 years suffering 5 cities region. Asthma diagnosed according Global Initiative for guidelines, allergic ARIA guidelines. ImmunoCAP skin prick test were used assess spectrum. Results. Among patients 144...

The objective of the study was to investigate prevalence, clinical and allergological features, risk factors bronchial asthma in pre-school children living urban areas Altay Krai. Methods. This a cross-sectional involving 3,205 (age, 3 6 years) attending facilities 5 cities Asthma symptoms were defined using ISAAC questionnaire. diagnosed by clinicians according GINA. Results. Prevalence aged years 5.7%; 62.7% them previously with asthma. Majority (59.4%) had mild Sensitization detected...

Обновление. Рецидивирующий бронхообструктивный синдром (БОС) повышает риск развития бронхиальной астмы (БА) у детей. Есть сведения о том, что повышение уровня периостина в крови может быть предиктором БА, обосновывает необходимость исследования этого показателя пациентов с рецидивирующим БОС. Однако до последнего времени не изучен уровень сывороточного детей дошкольного возраста Цель. Определить 34 лет БОС и здоровых сверстников. Материалы методы. Проведено одномоментное исследование (более...

Уровень сывороточного периостина у детей с положительным

Background. The level of serum periostin in preschool children with recurrent wheezing episodes has been studied. Objective. To determine the episodes, compared to healthy children. Results. 101 3-4 years old took part study, 72 them had (more than 3 over past year) and 29 - individuals. Statistically significant differences between were not found. (median, quartile) is 3.0 (1.8; 4.0) ng/ml 2.7 (1.7; 3.6) (p=0.296). area under ROC curve (AUC) was 0.56 (95% CI 041-0.68). Conclusion. does differ from

Various conclusive evidence on the role of vitamin D in pathogenesis atopic dermatitis (AD) has been obtained recent decades. Many studies have shown that patients with AD low concentration 25(OH)D blood associated high allergen specific IgE (according to several reports). The analysis prevalence, association deficiency severity and sensitization allergens, disorders risk development is presented.