A5082175165- Pharmaceutical Practices and Patient Outcomes
- Metabolism and Genetic Disorders
- Birth, Development, and Health
- Innovations in Medical Education
- Epigenetics and DNA Methylation
- Infant Nutrition and Health
- RNA modifications and cancer
- Higher Education Teaching and Evaluation
- Folate and B Vitamins Research
- Fatty Acid Research and Health
- Pharmacy and Medical Practices
- Diet and metabolism studies
- Digestive system and related health
- Muscle metabolism and nutrition
- Clinical Nutrition and Gastroenterology
- Biochemical and Molecular Research
- Pharmacology and Obesity Treatment
- Health and Medical Education
- Cholesterol and Lipid Metabolism
- Delphi Technique in Research
- HER2/EGFR in Cancer Research
- Diet, Metabolism, and Disease
- Pharmaceutical studies and practices
- Glycogen Storage Diseases and Myoclonus
- Gestational Diabetes Research and Management
Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research
2020-2024
Universidad de Granada
2015-2024
Genomics (United Kingdom)
2024
Instituto de Investigación Biosanitaria de Granada
2022
Universitat de Barcelona
2000
Icahn School of Medicine at Mount Sinai
1990
Long INterspersed Element class 1 (LINE-1) elements are a type of abundant retrotransposons active in mammalian genomes. An average human genome contains ~100 retrotransposition-competent LINE-1s, whose activity is influenced by the combined action cellular repressors and activators. TREX1, SAMHD1 ADAR1 known LINE-1 when mutated cause autoinflammatory disorder Aicardi-Goutières syndrome (AGS). Mutations RNase H2 most common AGS, its was proposed to similarly control retrotransposition. It...
Abstract An adverse intrauterine or periconceptional environment, such as hyperglycemia during pregnancy, can affect the DNA methylation pattern both in mothers and their offspring. In this study, we explored epigenetic profile maternal peripheral blood samples through pregnancy to find potential biomarkers for gestational diabetes mellitus (GDM), well candidate genes involved GDM development. We performed an epigenome-wide association study 32 pregnant women (16 with 16 non-GDM) at week...
The changes in the absolute and relative contents of α- ĸ-caseins, lactoferrin, α-lactalbumin, serum albumin lysozyme human milk have been studied through period lactation. Protein fractions 209 samples were analyzed by a discontinuous poly-acrylamide gel electrophoresis method, β- ĸ -caseins decreased from colostrum to mature although their percentages remained constant. They accounted for 12–15 9–13% total protein milk, respectively. Lactoferrin amounts with advancing This represented...
MTBVAC is a live attenuated M. tuberculosis vaccine constructed by genetic deletions in the phoP and fadD26 virulence genes. The currently phase 2 clinical trials with newborns adults South Africa, one of countries highest incidence. Although has been extensively characterized genomics, transcriptomics, lipidomics, proteomics, its metabolomic profile yet unknown. Accordingly, this study we aim to identify differential metabolites between MTBVAC. To end, an untargeted metabolomics approach...
PHAR-QA, funded by the European Commission, is producing a framework of competences for pharmacy practice. The in line with EU directive on sectoral professions and takes into account diversity profession on-going changes healthcare systems (with an increasingly important role pharmacists), pharmaceutical industry. PHAR-QA asking academia, students practicing pharmacists to rank required results show that areas “drug interactions”, “need drug treatment” “provision information service” were...
The objective of the PHAR-QA (Quality assurance in European pharmacy education and training) project was to investigate how competence-based learning could be applied a healthcare, sectoral profession such as pharmacy. This is first study on evaluation competences from pharmacists’ perspective using an improved Delphi method with large number respondents all over Europe. paper looks at way which hospital pharmacists rank fundamental for practice. (n = 152) ranked 68 practice two types...
This paper presents the results of second European Delphi round on ranking competences for pharmacy practice and compares these data to those first already published. A comparison numbers respondents, distribution by age group, country residence, etc., shows that whilst student population respondents changed from Round 1 2, populations professional groups (community, hospital industrial pharmacists, pharmacists in other occupations academics) were more stable. Results are given consensus...
Abstract Emerging studies support that the polycomb repressive complex 2 (PRC2) regulates phenotypic changes of carcinoma cells by modulating their shifts among metastable states within epithelial and mesenchymal spectrum. This new role PRC2 in cancer has been recently proposed to stem from ability its catalytic subunit EZH2 bind modulate transcription genes during epithelial-mesenchymal transition (EMT) lung cells. Here, we asked whether this mechanism is conserved other types carcinomas....
This paper looks at the opinions of 241 European academics (who provide pharmacy education), and 258 community pharmacists apply it), on competences for practice. A proposal was generated by a panel experts using Delphi methodology. Once finalized, then submitted to large, European-wide practicing in an additional round. Academics practitioners recognized importance notion patient care competences, underlining nature pharmacist as specialist medicines. The survey revealed certain...
Mammals optimize their physiology to the light-dark cycle by synchronization of master circadian clock in brain with peripheral clocks rest tissues body. Circadian oscillations rely on a negative feedback loop exerted molecular that is composed transcriptional activators Bmal1 and Clock, regulators Period Cryptochrome. Components are expressed during early development, but onset robust only detected later embryogenesis. Here, we have used naïve pluripotent mouse embryonic stem cells (mESCs)...
The influences of the maternal diet and mothers' nutritional socioeconomic status on fatty acid composition human milk have not yet been fully elucidated. Fatty acids from capric (8:0) to docosahexaenoic (22:6w3) were determined in 209 samples obtained voluntary donors. Samples classified according time lactation relation weight lactating women. Capric lauric increased mature while palmitic stearic decreased. Polyunsaturated (PUFA) w6 w3 series with more than 18 carbon atoms also decreased...