A5059978407- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiovascular and Diving-Related Complications
- Respiratory Support and Mechanisms
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and exercise physiology
- Cardiac pacing and defibrillation studies
- Cardiac Health and Mental Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Congenital Heart Disease Studies
- Muscle metabolism and nutrition
- Cardiovascular Effects of Exercise
- Spine and Intervertebral Disc Pathology
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Syncope and Autonomic Disorders
- Gastroesophageal reflux and treatments
- Geology and Paleoclimatology Research
- Geochemistry and Elemental Analysis
- Cardiac Fibrosis and Remodeling
- Ecology, Conservation, and Geographical Studies
University of Iowa
2024
Fondazione Toscana Gabriele Monasterio
2017-2023
Azienda Ospedaliera Universitaria Pisana
2019-2023
University of Pisa
2019-2023
University of Rochester
2022-2023
Collegio Carlo Alberto
2023
Équipe Littérature et Culture italiennes
2022
Scuola Superiore Sant'Anna
2014-2022
Regione Toscana
2021-2022
Sapienza University of Rome
2022
Background A thorough analysis of noncardiac determinants mortality in heart failure ( HF ) is missing. Furthermore, evidence conflicts on the outcome patients with and no or mild systolic dysfunction. We aimed to investigate prevalence cardiac causes death a cohort chronic patients, covering whole spectrum function. Methods Results enrolled 2791 stable classified into reduced ejection fraction r EF ; left ventricular [EF] <40%), HR midrange mr 41–49%), preserved p ≥50%), followed up for...
Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden. The main effect of the process involves alteration nucleus pulposus (NP) via cell-mediated enzymatic breakdown key extracellular matrix (ECM) components. Thus, development injectable and biomimetic biomaterials that can instruct regenerative cell component to produce tissue-specific ECM pivotal for IVD repair. Chondroitin sulfate (CS) type II collagen are primary components NP tissue...
Background The contribution of the lung or plant gain ( PG ; ie, change in blood gases per unit ventilation) to Cheyne-Stokes respiration CSR ) heart failure has only been hypothesized by mathematical models, but never directly evaluated. Methods and Results Twenty patients with systolic (age, 72.4±6.4 years; left ventricular ejection fraction, 31.5±5.8%), 10 relevant (24-hour apnea-hypopnea index [ AHI ] ≥10 events/h) without <10 at 24-hour cardiorespiratory monitoring underwent evaluation...
Background: Although central apneas (CA) and obstructive (OA) are highly prevalent in heart failure (HF), a comparison of apnea prevalence, predictors clinical correlates the whole HF spectrum, including with reduced ejection fraction (HFrEF), mid-range EF (HFmrEF) preserved (HFpEF) has never been carried out so far. Materials methods: 700 patients were prospectively enrolled then divided according to left ventricular (408 HFrEF, 117 HFmrEF, 175 HFpEF). All underwent thorough evaluation...
Heart failure with preserved ejection fraction (HFpEF) is highly prevalent and associated relevant morbidity mortality. However, an evidence-based treatment still absent. The heterogeneous definitions, differences in aetiology/pathophysiology, diagnostic challenges of HFpEF made it difficult to define its epidemiological landmarks so far. Several large registries observational studies have recently disclosed increasing incidence/prevalence, as well prognostic significance. An accurate...
Dyspnoea often occurs in patients with acute coronary syndrome (ACS) treated ticagrelor compared other anti-platelet agents and is a cause of drug discontinuation. We aimed to explore the contribution central apnoeas (CA) chemoreflex sensitization ticagrelor-related dyspnoea ACS.Sixty consecutive ACS, preserved left ventricular ejection fraction, no history obstructive sleep apnoea, either 90 mg b.i.d. (n = 30) or prasugrel 10 o.d. were consecutively enrolled. One week after all underwent...
Background Central apneas (CA) are a frequent comorbidity in patients with heart failure (HF) and associated worse prognosis. The clinical prognostic relevance of CA each sex is unknown. Methods Results Consecutive outpatients HF either reduced or mildly left ventricular ejection fraction (n=550, age 65±12 years, 32%±9%, 21% women) underwent 24-hour ambulatory polygraphy to evaluate burden were followed up for the composite end point cardiac death, appropriate implantable...
The intervertebral disc (IVD) relies mainly on diffusion through the cartilaginous endplates (CEP) to regulate nutrient and metabolites exchange, thus creating a challenging microenvironment. Degeneration of IVD is associated with intradiscal acidification elevated levels pro-inflammatory cytokines. However, synergistic impact these microenvironmental factors for cell-based therapies remains be elucidated. aim this study was investigate effects low pH physiological interleukin-1ß (IL-1β)...
Background: Periodic breathing (PB) is a cyclical pattern composed of alternating periods hyperventilation (hyperpnea, HP) and central apnea (CA). Differences in PB phenotypes mainly reside HP length. Given that respiration modulates muscle sympathetic nerve activity (MSNA), which decreases during increases CA, the net effects on MSNA may critically depend Objectives: We hypothesized with shorter associated increased decreased heart rate variability. Methods: 10 healthy participants...