A5043603090- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Fungal and yeast genetics research
- Mycotoxins in Agriculture and Food
- Plant-Microbe Interactions and Immunity
- Plant Pathogens and Fungal Diseases
- Magnolia and Illicium research
- Antibiotic Use and Resistance
- Polysaccharides and Plant Cell Walls
- Cystic Fibrosis Research Advances
- Organoselenium and organotellurium chemistry
- Bacterial biofilms and quorum sensing
- Nematode management and characterization studies
- Biochemical and Molecular Research
- Oral microbiology and periodontitis research
- Oxidative Organic Chemistry Reactions
- Renal Transplantation Outcomes and Treatments
- Plant Parasitism and Resistance
- Fungal Biology and Applications
- Plant and animal studies
- Mycorrhizal Fungi and Plant Interactions
Université de Bretagne Occidentale
2021-2025
Nantes Université
2024-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024-2025
Université d'Angers
2021-2025
PhysioPathologie des Adaptations Nutritionnelles
2024-2025
Centre Hospitalier Universitaire d'Angers
2021-2023
Background Scedosporium species are filamentous fungi causing a wide spectrum of infections in healthy and debilitated individuals. Despite their clinical significance, the ecology remains understudied, particularly Middle East. Methods In this context, we conducted an environmental study to elucidate distribution ecological preferences North Lebanon. One hundred fifty-five soil samples were collected from different areas analyzed for several chemical parameters. isolates then selected...
Like bacteria and plants, fungi produce a remarkable diversity of small molecules with potent activities for human health known as natural products or secondary metabolites. One such example is mycophenolic acid (MPA), powerful immunosuppressant drug that administered daily to millions transplant recipients worldwide. Production MPA restricted very limited number filamentous fungi, little about its biosynthetic modalities. It therefore particular challenge improve our knowledge the...
Scedosporium species are common fungal pathogens in patients with cystic fibrosis (CF). To colonize the CF lungs, fungi must cope host immune response, especially reactive oxygen (ROS) released by phagocytic cells. this aim, have developed various antioxidant systems, including superoxide dismutases (SODs) which constitute first-line protection against oxidative stress. Interestingly, one of S. apiospermum SOD-encoding genes (SODD gene) exhibits a glycosylphosphatidylinositol (GPI)...
The slowing-down de novo drug-discovery emphasized the importance of repurposing old drugs. This is particularly true when combating infections caused by therapy-refractory microorganisms, such as Scedosporium species and Lomentospora prolificans. Recent studies on responses to oxidative stress underscored targeting underlying mechanisms. Auranofin, ebselen, PX-12, honokiol, a lesser extent, conoidin A are known disturb redox-homeostasis systems in many organisms. Their antifungal activity...
Signals are exchanged at all stages of the arbuscular mycorrhizal (AM) symbiosis between fungi and their host plants. Root-exuded strigolactones well-known early symbiotic cues, but role other phytohormones as interkingdom signals has seldom been investigated. Here we focus on ethylene cytokinins, for which candidate receptors have identified in genome AM fungus Rhizophagus irregularis. Ethylene is known from literature to affect asymbiotic development fungi, present study, found that three...
Scedosporium species are opportunistic filamentous fungi found in human-impacted areas. Clinically relevant species, such as S. apiospermum, rank the second most frequent colonizers of airways patients with cystic fibrosis (CF), which characterized by persistent oxidative stress. This raises question how abate conditions imposed hostile environments. Since High Osmolarity Glycerol (HOG) pathway plays a central role fungal adaptation to stress, we aimed pheno-profile involvement response...