A5068708325- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Peptidase Inhibition and Analysis
Charité - Universitätsmedizin Berlin
2019-2023
Freie Universität Berlin
2022-2023
Humboldt-Universität zu Berlin
2022-2023
Abstract Ribosome biogenesis is a fundamental multi-step cellular process in all domains of life that involves the production, processing, folding, and modification ribosomal RNAs (rRNAs) proteins. To obtain insights into still unexplored early assembly phase bacterial 50S subunit, we exploited minimal vitro reconstitution system using purified components scalable reaction conditions. Time-limited assays combined with cryo-EM analysis visualizes structurally complex pathway starting particle...
Abstract Ribosome biogenesis is a fundamental multi-step cellular process in all domains of life that involves the production, processing, folding, and modification ribosomal RNAs (rRNAs) proteins. To obtain insights into still unexplored early assembly phase bacterial 50S subunit, we exploited minimal vitro reconstitution system using purified components scalable reaction conditions. Time-limited assays combined with cryo-EM analysis visualizes structurally complex pathway starting particle...