A5052708157- Cancer, Lipids, and Metabolism
- Neurobiology and Insect Physiology Research
- Lipid metabolism and biosynthesis
- Melanoma and MAPK Pathways
- Peroxisome Proliferator-Activated Receptors
- Animal Genetics and Reproduction
- Telomeres, Telomerase, and Senescence
- Metabolomics and Mass Spectrometry Studies
- Nonmelanoma Skin Cancer Studies
- Global Health and Surgery
- Robotics and Automated Systems
- Ubiquitin and proteasome pathways
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Fungal Plant Pathogen Control
- Physiological and biochemical adaptations
- Parallel Computing and Optimization Techniques
- CRISPR and Genetic Engineering
- Bioactive natural compounds
- Retinal Development and Disorders
- Biological Activity of Diterpenoids and Biflavonoids
- EEG and Brain-Computer Interfaces
- Cutaneous Melanoma Detection and Management
- Animal Behavior and Reproduction
- Travel-related health issues
- Global Healthcare and Medical Tourism
Baylor College of Medicine
2025
University of South Florida
2024
University of California, Merced
2021
Cedars-Sinai Medical Center
2019-2020
University of California, Los Angeles
2007
In primary mammalian cells, oncogenic ras induces premature senescence, depending on an active MEKextracellular signal-regulated kinase (ERK) mitogen-activated protein (MAPK) pathway.It has been unclear how activation of the mitogenic MEK-ERK pathway by can confer growth inhibition.In this study, we have found that stress-activated MAPK, p38, is also activated during onset ras-induced senescence in human fibroblasts.Constitutive p38 MKK3 or MKK6 senescence.Oncogenic fails to provoke when...
Thirst is a motivational state that drives behaviors to obtain water for fluid homeostasis. We identified two types of central brain interneurons regulate thirsty seeking in Drosophila , we term the Janu neurons. Janu-GABA, local interneuron subesophageal zone, activated by deprivation and specific seeking. Janu-AstA projects from zone superior medial protocerebrum, higher order processing area. signals with neuropeptide Allatostatin A promote inhibit feeding behavior. NPF ( NPY) neurons are...
Existing therapeutic strategies for breast cancer are limited by tumor recurrence and drug-resistance. Antioxidant plant-derived compounds such as flavonoids reduce adverse outcomes have been identified a potential source of antineoplastic agent with less undesirable side effects. Here, we describe the novel regulation fatty-acid synthase (FASN), key enzyme in de novo synthesis, whereby Vitis vinifera L. cv Vermentino leaf hydroalcoholic extract lowers its protein stability that is regulated...
Ethanol abuse promotes breast cancer development, metastasis and recurrence stimulating mammary tumorigenesis by mechanisms that remain unclear. Normally, 35% of is Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2)-positive predisposes to poor prognosis relapse, while ethanol drinking leads invasion their ERBB2 positive cells triggering the phosphorylation status mitogen-activated protein kinase. StAR-related lipid transfer 10 (STARD10) a transporter phosphatidylcholine (PC) phosphatidylethanolamine...
Abstract Background: Existing therapeutic strategies for breast cancer are limited by tumor recurrence and drug-resistance. Several epidemiological studies indicate that antioxidant plant-derived compounds such as flavonoids reduce adverse outcomes have been identified a potential source of antineoplastic agent with less undesirable side effects. Activation lipid metabolism is an early event in carcinogenesis central hallmark cancer. In fact, inhibition fatty-acid synthesis results...
Background Existing therapeutic strategies for breast cancer include surgery, endocrine therapy, and chemotherapy are limited by tumor recurrence drug‐resistance, novel approaches need to improve current clinical protocols. A number of epidemiological studies indicate that antioxidant plant‐derived compounds such as flavonoids reduce adverse outcomes reactive species have been identified a potential source antineoplastic cytotoxic agents with less undesirable side effects. It is well known...