A5092160419- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- X-ray Diffraction in Crystallography
- Sulfur-Based Synthesis Techniques
- Crystallization and Solubility Studies
- Catalytic Cross-Coupling Reactions
- Chemical synthesis and alkaloids
University of Regensburg
2023-2024
Bayer (Germany)
2024
We present a novel copper-catalyzed method for aniline cross-couplings promoted by 6-hydroxy picolinhydrazide ligand. The achieves room-temperature reactivity with aryl bromides, enabled methanol/ethanol solvent mixture and mild, functional group-compatible base, catalyst loadings as low 0.5 mol %. use of industrially preferred solvents well the high catalytic activity, offers significant advancement in practicality scalability industrial processes. Furthermore, approach extends to...
The development of predictable methods to increase molecular complexity is paramount importance in modern organic chemistry, especially the context synthesizing multifunctionalized (het)arenes active pharmaceutical ingredients (APIs) and materials. While considerable progress has been made using various protocols, sequential one-pot carbon–heteroatom cross-coupling reactions remain challenging. Herein, we report reaction conditions under adaptive dynamic homogeneous catalysis (AD-HoC) that...
Transition metal catalysis is crucial for the synthesis of complex molecules, with ligands and bases playing a pivotal role in optimizing cross-coupling reactions. Despite advancements ligand design base selection, achieving effective synergy between these components remains challenging. We present here general approach to nickel-catalyzed photoredox reactions employing tert-butylamine as cost-effective bifunctional additive, acting ligand. This method proves C-O C-N bond-forming diverse...
Biaryl amines are essential structural motifs prevalent in agrochemicals, pharmaceuticals, and materials. Herein, we present a novel copper-catalyzed method for aniline cross-couplings promoted by 6-hydroxy picolinhydrazide ligand. The achieves room-temperature reactivity with aryl bromides, enabled methanol/ethanol solvent mixture mild, functional group-compatible base, catalyst loadings as low 0.5 mol%. use of industrially preferred bases solvents, well the high catalytic activity, offers...