A5075927532- Inflammatory mediators and NSAID effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Crystal structures of chemical compounds
- X-ray Diffraction in Crystallography
- Synthesis and Reactivity of Heterocycles
- Nitric Oxide and Endothelin Effects
- Platelet Disorders and Treatments
- Synthesis and Catalytic Reactions
- Organophosphorus compounds synthesis
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Pharmacological Receptor Mechanisms and Effects
- Synthesis and Biological Evaluation
- Eicosanoids and Hypertension Pharmacology
University of Turin
2008-2013
University of Parma
2008
A series of (nitrooxyacyloxy)methyl esters aspirin were synthesized and evaluated as new NO-donor aspirins. Different amounts released in serum from these products according to the nature nitrooxyacyloxy moiety present. In aromatic series, there is a rather good linear correlation between amount potencies inhibiting platelet aggregation induced by collagen. Both native compounds related nitrooxy-substituted acid metabolites able relax rat aorta strips precontracted with phenylephrine,...
A new class of products in which the phenol group salicylic acid is linked to alkanoyl moieties bearing nitrooxy functions has been synthesized and studied for their polyvalent actions. The were stable neutral media, while they hydrolyzed human serum. Their half-lives dependent upon structure moieties. showed anti-inflammatory activities similar aspirin when tested carrageenan-induced paw edema assay rat. Interestingly, unlike aspirin, reduced or no gastrotoxicity a lesion model rats at...
Abstract A series of water‐soluble (benzoyloxy)methyl esters acetylsalicylic acid (ASA), commonly known as aspirin, are described. The new derivatives each have alkyl chains containing a nitric oxide (NO)‐releasing nitrooxy group and solubilizing moiety bonded to the benzoyl ring. compounds were synthesized evaluated ASA prodrugs. After conversion appropriate salt, most solid at room temperature all possess good water solubility. They quite stable in solution (pH 1) less physiological pH. In...
In a previous study, the X-ray structure of title compound, C9H12N2O7P2·H2O, was reported [Takeuchi et al., (1998 ▶). Chem. Pharm. Bull. 46, 1703-1709], but neither atomic coordinates nor details geometry were published. The has been redetermined with high precision as its detailed knowledge is essential to elucidate presumed polymorphism minodronic acid monohydrate at room temperature. mol-ecule crystallizes in zwitterionic form cationic imidazolium[1,2a]pyridine and anionic phospho-nate...
A very efficient, cost-effective, and easily scalable process for the synthesis of lofexidine hydrochloride (1), an alpha 2-adrenergic receptor agonist used treating opioid withdrawal is presented. Process development allows preparation (1) through a one-pot amidation/imidazoline ring formation reaction, starting from ethyl 2-(2,6-dichlorophenoxy)propionate (13) ethylenediamine (5) by action titanium isopropoxide. The required intermediate can efficiently be obtained O-alkylation...