We report on a probably new form of spondyloepimetaphyseal dysplasia (SEMD) with an X linked inheritance pattern. Eight males were affected in the same family. able to examine three adult patients and we studied skeletal radiological aspect one these at 2 years 6 months 9 age. The main clinical features are severe short trunked dwarfism, brachydactyly, normal facies, intelligence. Radiologically, diaphyses all long bones broad. epiphyses distal portion femora those proximal portions tibia...

Background: Renal cysts are fluid-filled sacs that develop within or on the kidneys, often detected incidentally during routine ultrasonographic examinations. Although usually benign, renal can be associated with systemic conditions and contribute to dysfunction in certain cases. Identifying their prevalence risk factors is essential for early diagnosis management. Hypertension, diabetes mellitus, age-related changes have been recognized as potential contributors cyst development, yet exact...

Background: Health care systems are foundational to public well-being and vary significantly across nations, especially in low- middle-income countries. Pakistan Nepal, while geographically proximate, differ system structures, resource allocation, policy priorities. Objective: To compare analyze the health of Nepal using World Organization (WHO) System Framework, focusing on governance, financing, workforce, service delivery, technology, information systems, indicators. Methods: This...

Background: Negligence and compromised accountability remain pressing issues in healthcare, often resulting preventable patient harm undermining trust medical institutions. Despite established ethical codes clinical guidelines, there is a notable gap understanding how systemic factors provider behavior contribute to adverse outcomes, particularly acute scenarios like obstetric emergencies. Objective: This study aims critically examine the challenges surrounding negligence care, focusing on...

Background : All 5‐aminosalicylic acid (5‐ASA) preparations are potentially nephrotoxic, but there has been concern that newer delivery systems may increase this risk, either because of altered absorption or metabolism. Previous studies 5‐ASA and excretion have usually performed in healthy controls only examined short‐term therapy. N ‐acetyl‐5‐ASA therefore measured blood samples, urine from patients with ulcerative colitis on long‐term maintenance different compared sensitive markers renal...

To investigate possible mechanisms of hydrocarbon or solvent-induced renal damage, we studied three groups healthy men employed in a UK manufacturing plant. Group 1 (n = 111) were occupationally exposed to hydrocarbon-based paints, 2 100) petroleum-based mineral oils, and 3 92) had low background occupational exposure hydrocarbons. Occupational atmospheric levels for toluene, xylene, butanol oil mist around the time this study within permissible limits. 4 (controls) males with no known...

Introduction Despite the use of unfractionated heparin (UFH) or low molecular weight (LMWH), rates thromboembolic disease, and subsequent morbidity mortality remain unacceptably high in patients with severe novel coronavirus disease 2019 (COVID-19) disease. Direct oral anticoagulants (DOACs), such as apixaban, have numerous purported benefits although safety efficacy their intensive care unit (ICU) COVID-19 has yet to be evaluated. Materials Methods Single-center, retrospective cohort study...

INTRODUCTION: Dialysis has been associated with acute changes in the complement activation status, granulocyte markers, macrophage function, T cell and release of pro-inflammatory cytokines. The most common analysis cytokine production patients on dialysis focused monokines (particularly IL-1 TNF alpha), however it is becoming clear that cytokines play a major role impaired lymphocyte function patients. METHODS: To assess effect modality we analysed ability cells within peripheral blood...

OXA-48-producing isolates were identified in approximately 4% and less than 1% of ESBL-producing non-ESBL-producing E. coli K. pneumoniae causing bacteremia at the largest tertiary hospital Abu Dhabi.

Exposure to hydrocarbons has been implicated in the pathogenesis of glomerulonephritis but its role development diabetic nephropathy remains unknown. Three groups patients with Type 1 diabetes over 10 years duration were studied. Group comprised 45 (23 F) no (urinary albumin excretion (AER) < 30 mg 24 h-1), group 2 37 (17 incipient (AER between 30-300 and 3 31 (15 overt > 300 h-1). The comparable for age, sex, diabetes, recent glycaemic control, social class, residential area. Patients...

Haemodialysis-related porphyria cutanea tarda is a rare, but serious and mutilating skin condition, resulting from extremely high plasma porphyrin levels because of their inadequate clearance by haemodialysis. The treatment very difficult as chloroquine ineffective venesection, the conventional this disease, not always an option anaemia end-stage renal disease. We report case haemodialysis-related her successful management recombinant human erythropoietin treatment.

To investigate the pathophysiology of hypertension in patients receiving recombinant human erythropoietin (rHuEpo) we studied its effects on renin-aldosterone axis chronic haemodialysis (HD) not antihypertensive drugs. Nine severely anaemic normotensive HD received rHuEpo 50 U/kg bodyweight, thrice weekly after each HD. The dose was increased by 25 bodyweight every 4 weeks to a maximum 100 or until an increase Hb Hct 2 g/dl 7% achieved. Blood samples were taken 30 min supine rest and while...

Prevention quality indicators (PQIs) are used in hospital discharge data sets to identify of care for ambulatory care-sensitive conditions, such as diabetes. We examined the impact clinical integration efforts on diabetes-related PQIs a large community-based health organization. Inpatient and observation hospitalizations from nine acute hospitals were trended over 5 years (2012-2016). Using established technical specifications, annual rates calculated four PQIs: uncontrolled diabetes,...

Summary Seventeen severely anaemic and transfusion-dependent haemodialysis patients with a haemoglobin less than 7 g/dl were treated recombinant human erythropoietin (r-Hu-EPO). Aluminium toxicity was diagnosed by positive desferrioxamine (DFO) test bone biopsy. Seven out of eight without aluminium responded to r-Hu-EPO therapy. Similarly all (n = 4) but pre-treated standard dose DFO prior therapy none the untreated 5) In order achieve adequate response in these patients, had be given...