A5044739710- Epigenetics and DNA Methylation
- Multiple Sclerosis Research Studies
- Genetic Associations and Epidemiology
- Identity, Memory, and Therapy
- Systemic Lupus Erythematosus Research
- Physical Activity and Health
- Long-Term Effects of COVID-19
- Sports Performance and Training
- Genetic and phenotypic traits in livestock
- Neuroinflammation and Neurodegeneration Mechanisms
- Dietary Effects on Health
- Tryptophan and brain disorders
- Genomics and Chromatin Dynamics
- RNA regulation and disease
- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- Adolescent and Pediatric Healthcare
- Cardiovascular and exercise physiology
- Pregnancy and Medication Impact
- Reproductive Health and Contraception
University of Pavia
2022-2024
The epigenetic status of patients 6-month post-COVID-19 infection remains largely unexplored. existence long-COVID, or post-acute sequelae SARS-CoV-2 (PASC), suggests potential long-term changes. Long-COVID includes symptoms like fatigue, neurological issues, and organ-related problems, regardless initial severity. mechanisms behind long-COVID are unclear, but virus-induced changes could play a role. Our study explores the lasting impacts infection. We analyzed genome-wide DNA methylation...
Major depressive disorder (MDD) is a prevalent mental health condition with substantial social and economic consequences. This study focuses on the interplay between genetic environmen-tal factors in MDD, particular emphasis epigenetic mechanisms such as stochastic epige-netic mutations (SEMs), age acceleration, drift. We conducted meta-analysis of DNA methylation patterns across six datasets (n=1125 MDD cases, 398 controls whole blood; n=95 96 brain tissues) from Gene Expression Omnibus....
ObjectiveTo investigate the association between oral contraceptive (OC) pill use and risk of developing multiple sclerosis (MS), attempting to address limitations present in previous studies that produced conflicting results.DesignA population-based cohort study using data from UK Biobank.PatientsThe included 181,058 women white ethnicity born England 1937 1970, among which 1,131 had an MS diagnosis.InterventionOral use, considering self-reported age initiation discontinuation. The exposures...
Major depressive disorder (MDD) is a mental health condition that can severely impact patients' social lives, leading to withdrawal and difficulty in maintaining relationships. Environmental factors such as trauma stress worsen MDD by interacting with genetic predispositions. Epigenetics, which examines changes gene expression influenced the environment, may help identify patterns linked depression. This study aimed explore epigenetic mechanisms behind analysing six public datasets (n = 1125...
Background Multiple sclerosis (MS) is an autoimmune condition characterized by inflammatory and neurodegenerative traits. Recently, DNA methylation has emerged as a promising field of investigation for elucidating dynamics characterizing MS development progression. Objectives This study aimed to comprehensively investigate the role epigenetics in analyzing profiles from blood brain tissues public datasets. Methods Employing meta-analytical framework differential analyses, extended beyond...
This work aimed at estimating narrow-sense heritability, defined as the proportion of phenotypic variance explained by sum additive genetic effects, via Haseman–Elston regression for a subset 56 plasma protein levels related to Multiple Sclerosis (MS). These were measured in 212 individuals (with 69 MS cases and 143 healthy controls) obtained from 20 Sardinian families with history. Using pedigree information, we found seven statistically significant heritable (after multiple testing...