SUMMARY A survey has been conducted in Whickham, County Durham, to determine the prevalence of thyroid disorders community. Two thousand seven hundred and seventy‐nine people (82.4% available sample) were seen survey. The overt hyperthyroidism was 19/1000 females rising 27/1000 when possible cases included, compared with 1.6–2.3/1000 males. hyothyroidism 14/1000 less than 1/1000 spontaneous hypothyroidism (excluding iatrogenic cases) 10/1000 or 15/1000 including unconfirmed cases. Minor...

Summary BACKGROUND AND OBJECTIVE The original Whlckham Survey documented the prevalence of thyroid disorders in a randomly selected sample 2779 adults which matched population Great Britain age, sex and social class. aim twenty‐year follow‐up survey was to determine Incidence natural history disease this cohort. DESIGN, PATIENTS MEASUREMENTS Subjects were traced at via Electoral Register, General Practice registers, Gateshead Family Health Services Authority register Office Population...

In an attempt to derive estimates of the incidence and prevalence acromegaly a survey population in area served by former Newcastle Regional Hospital Board has been conducted detect cases alive after 1 January 1960 diagnosed before 31 December 1971. Cases were detected means letters general practitioners, hospital physicians, neurosurgeons records officers, as well from death certificates. From 3.1 millions firm diagnosis was made 164 patients, eighty-one on clinical grounds alone...

Modelling Biological Populations in Space and Time. By E. Renshaw. ISBN 0 521 30388 5. Cambridge University Press, Cambridge, 1991. xviii + 404 pp. £60.00.

One hundred and sixty-three asymptomatic people with thyroid antibodies or raised serum thyrotrophin (TSH) concentrations, both, 209 age-matched sex-matched controls without either marker of disorder were followed up for four years to determine the natural history autoimmune thyroiditis. Mildly TSH concentrations alone presence did not significantly increase risk developing overt hypothyroidism during compared controls. Overt developed at rate 5% a year in women who initially had both...

Epidermal growth factor receptors are present in some breast cancers man, and there is an inverse relation to oestrogen receptor state. We assessed the presence of epidermal as a single prognostic indicator series tumours by comparing this with Bloom Richardson scores for these tumours. One hundred eight ductal were examined radioligand binding. There was significant (p less than 0.01) correlation between poor prognosis score, suggesting that state could be useful marker. not significantly...

The original Whickham Survey documented risk factors for cardiovascular disease and the prevalence of thyroid disorders in a sample 2779 adults that closely matched British population. A 20-year follow-up study has determined outcomes terms morbidity mortality from ischemic heart over 97% survey Analysis deaths all causes showed no association with antithyroid antibody status identified at first survey. multiple logistic regression using development total population as dependent variable...

SUMMARY The age and sex distribution of ischaemic heart disease (IHD), other vascular disorders serum lipid concentrations the possible association between these factors thyroid failure have been examined in a community survey. A past history IHD occurred 7.5% males 4.8% females.‘Chest pain on effort’was found 7.4% 7.8% females and‘possible infarction’in 5.4% 3.8% females. Major ECG changes were 4.7% both sexes minor 6.5% 11% Intermittent claudication was present cerebrovascular accidents...

A methanol-soluble extract of the bark Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led identification active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in presence a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, quorum sensing-regulated pyocyanin biofilm formation Pseudomonas aeruginosa PAO1. These results suggest that...

A new method for the analysis of small-intestinal crypt-cell kinetics using routine peroral diagnostic biopsies is described. Untreated patients with childhood and adult coeliac disease adults gluten-sensitive enteropathy dermatitis herpetiformis were studied, together groups controls. In classical flat avillous mucosae increase in crypt size was found to be three-dimensional. The number proliferating cells per shown markedly increased, an even greater rise production rate demonstrated....

Abstract Sulindac, a non‐steroidal anti‐inflammatory drug, has been reported to lead tumour regression in cases of human polyposis coli. We have investigated the effects this drug on growth 1,2‐dimethylhydrazine (DMH)‐induced mouse colonic tumours. In one experiment, DMH and oral sulindac were administered concurrently group mice for period up 24 weeks, while control animals received only same period. Sulindac caused significant reduction both number with tumours per mouse. second two groups...

The pattern of breast-feeding in 127 infants admitted to hospital with respiratory syncytial virus infection was compared that 503 age-matched controls. Thirty per cent children had been breast-fed 49% approximate relative risk being if not 2.2. Several other factors were also considered, including an assessment maternal care and home environment; the mother9s age, marital state, smoking habits; number siblings; gestation. Adverse all associated increased admission infection, but still...

Summary The oil biosynthesis pathway must be tightly controlled to maximize yield. Oil palm accumulates exceptionally high content in its mesocarp, suggesting the existence of a unique fruit‐specific fatty acid metabolism transcriptional network. We report complex network transcription factors responsible for modulation genes mesocarp. Transcriptional activation Eg WRI 1‐1 encoding key master regulator that activates expression genes, is activated by three ABA ‐responsive factors, NF ‐ YA 3,...

Abstract GWAS in out-crossing perennial crops is typically limited by insufficient marker density to account for population diversity and effects of structure resulting high false positive rates. The crop oil palm the most productive crop. We performed oil-to-dry-mesocarp content (O/DM) on 2,045 genotyped tenera palms using 200K SNPs that were selected based short-range linkage disequilibrium distance, which inherent with long breeding cycles heterogeneous populations. Eighty loci...

Rossinones A (1) and B (2), biologically active meroterpene derivatives, were isolated from an Antarctic collection of the ascidian Aplidium species structurally characterized with spectroscopic methods. The absolute configuration 1 was deduced by using modified Mosher method. rossinones exhibit anti-inflammatory, antiviral antiproliferative activities.

A hyperproductive mucosal state in gluten-sensitive enteropathy has been proposed on the basis of an elevated mitotic index, but this parameter is dependent duration when used as index proliferative status. The was therefore measured two control patients with normal villous mucosae and flat avillous mucosa untreated enteropathy, using different stathmokinetic techniques vincristine. No significant difference found values obtained for cell cycle time showed a halving mucosae. An increased...