A5089938705- Clusterin in disease pathology
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- FOXO transcription factor regulation
- Ferroptosis and cancer prognosis
Second Affiliated Hospital of Guangzhou Medical University
2023
Guangzhou Medical University
2023
Sixth Affiliated Hospital of Sun Yat-sen University
2021
Sun Yat-sen University
2021
Abstract Cancer-associated fibroblasts (CAFs) have been shown to play a strong role in colorectal cancer metastasis, yet the underlying mechanism remains be fully elucidated. Using CRC clinical samples together with ex vivo CAFs-CRC co-culture models, we found that CAFs induce expression of Leucine Rich Alpha-2-Glycoprotein 1(LRG1) CRC, where it shows markedly higher metastatic tissues compared primary tumors. We further show CAFs-induced LRG1 promotes migration and invasion is concomitant...
e16083 Background: Stomach adenocarcinoma (STAD) ranks as the second incidence rate in China. The MisMatch Repair (MMR), composed of MLH1, MSH2, MSH3, MSH6, and PMS2, is a critical mechanism for repairing DNA error. In case microsatellite instability (MSI), MMR system capable mismatches. MSI-high (MSI-H) created result deficient mismatch repair (dMMR). A numerous studies have established clinical importance both MSI diagnosis, prognosis, treatment STAD. Circulating tumor (ctDNA) provides...