A5078750239- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Ion Transport and Channel Regulation
- Ion channel regulation and function
- Parathyroid Disorders and Treatments
- Alzheimer's disease research and treatments
- Nitric Oxide and Endothelin Effects
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Dietary Effects on Health
- Tryptophan and brain disorders
- Genetic Syndromes and Imprinting
- Adipose Tissue and Metabolism
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Biomedical Research and Pathophysiology
- Autophagy in Disease and Therapy
- Genomics, phytochemicals, and oxidative stress
- NF-κB Signaling Pathways
- PI3K/AKT/mTOR signaling in cancer
- Biochemical effects in animals
- Neurological Complications and Syndromes
- Advanced Glycation End Products research
Universidade de São Paulo
2016-2025
Hospital Universitário da Universidade de São Paulo
2025
Institute of Biomedical Science
2022
Instituto Butantan
2018-2019
Universidade Cidade de São Paulo
2018
National Institute on Aging
2011-2014
Institute on Aging
2011-2014
National Institutes of Health
2012-2013
Inflammation is a common component of acute injuries the central nervous system (CNS) such as ischemia, and degenerative disorders Alzheimer's disease. Glial cells play important roles in local CNS inflammation, an understanding for microRNAs glial reactivity injury disease settings may therefore lead to development novel therapeutic interventions. Here, we show that miR‐181 family developmentally regulated present high amounts astrocytes compared neurons. Overexpression miR‐181c cultured...
Systemic bacterial infections often result in enduring cognitive impairment and are a risk factor for dementia. There currently no effective treatments infection-induced impairment. Previous studies have shown that intermittent fasting (IF) can increase the resistance of neurons to injury disease by stimulating adaptive cellular stress responses. However, impact IF on sequelae systemic brain inflammation is unknown.Rats 30 days received 1 mg/kg lipopolysaccharide (LPS) or saline...
Although the anti-inflammatory actions of glucocorticoids (GCs) are well established in periphery, these stress hormones can increase inflammation under some circumstances brain. The transcription factor nuclear factor-κB (NF-κB), which is inhibited by GCs, regulates numerous genes central to inflammation. In this study, effects stress, and NMDA receptors on lipopolysaccharide (LPS)-induced activation NF-κB brain were investigated. One day after chronic unpredictable (CUS), nonstressed CUS...
Calcium (Ca2+) plays fundamental and diversified roles in neuronal plasticity. As second messenger of many signaling pathways, Ca2+ as been shown to regulate gene expression, energy production, membrane excitability, synaptogenesis, synaptic transmission, other processes underlying learning memory cell survival. The flexibility is achieved by modifying cytosolic concentrations via regulated opening plasmamembrane subcellular sensitive channels. spatiotemporal patterns intracellular signals,...
Epidemiological studies suggest that intrauterine undernutrition plays an important role in the development of arterial hypertension adulthood. In attempt to define mechanisms whereby blood pressure may be raised, we have hypothesized arteries from offspring nutritionally restricted dams exhibit abnormalities endothelial function and nitric oxide synthesis. order investigate existence potential gender differences on effects undernutrition, both male female pregnant Wistar rats normal diets...
Aging | doi:10.18632/aging.100853. Ana Maria Marques Orellana, Andrea Rodrigues Vasconcelos, Jacqueline Alves Leite, Larissa de Sá Lima, Diana Zukas Andreotti, Carolina Demarchi Munhoz, Elisa Mitiko Kawamoto, Cristoforo Scavone
Abstract Klotho is an antiaging protein, and its levels decline with age chronic stress. The exogenous administration of can enhance cognitive performance in mice negatively modulate the Insulin/IGF1/PI3K/AKT pathway terms metabolism. In humans, insulin sensitivity a hallmark healthy longevity. Therefore, this study aimed to determine if Klotho, when added neuronal astrocytic cell cultures, could reduce phosphorylation certain signaling effectors antioxidant strategies these cells. Primary...
Maternal undernutrition during critical periods of organ development is known to impair fetal growth and predispose the adulthood diseases, such as hypertension, coronary heart disease type II diabetes that are linked low birth weight characterized by endothelial dysfunction. Increased oxidative stress, in rats submitted intrauterine undernutrition, provides a potential explanation for dysfunction development. The aim this study was determine stress its consequence on mesenteric arteriolar...
Ouabain (OUA) is a newly recognized hormone that synthesized in the adrenal cortex and hypothalamus. Low doses of OUA can activate signaling pathway by interaction with Na,K-ATPase, which protective against number insults. has central peripheral anti-inflammatory effects. Lipopolysaccharide (LPS), via toll-like receptor 4 activation, widely used model to induce systemic inflammation. This study low dose evaluate its effects on inflammation induced LPS injection rats. Adult male Wistar rats...
Abstract Cocaine is a worldwide used drug and its abuse associated with physical, psychiatric social problems. The mechanism by which cocaine causes neurological damage very complex involves several neurotransmitter systems. For example, increases extracellular levels of dopamine free radicals, modulates transcription factors. NF-κB factor that regulates gene expression involved in cellular death. Our aim was to investigate the toxicity modulation activity PC 12 cells. Treatment (1 mM) for...
The Sonic hedgehog (Shh) signaling pathway is well known in patterning of the neural tube during embryonic development, but its emerging role differentiated neurons less understood. Here we report that Shh enhances autophagy cultured hippocampal neurons. Microarray analysis reveals upregulation multiple autophagy-related genes response to application. Through autophagy-marker LC3 by immunoblot and immunocytochemistry, confirm activation Shh-exposed Using electron microscopy, find...
Renal insufficiency can have a negative impact on cognitive function. Neuroinflammation and changes in klotho levels associate with chronic kidney disease (CKD) may play role the development of impairment (CI). The present study evaluates correlation deficits neuroinflammation soluble KLOTHO cerebral spinal fluid (CSF) brain tissue nephrectomized rats (Nx), 5/6 renal mass ablation. Nx sham Munich Wistar were tested over 4 months for locomotor activity, as well inhibitory avoidance or novel...
Mutations of the β-glucuronidase protein α-Klotho have been associated with premature aging, and altered cognitive function. Although highly expressed in specific areas brain, Klotho functions central nervous system remain unknown. Here, we show that cultured hippocampal neurons respond to insulin glutamate stimulation by elevating levels. Conversely, AMPA NMDA antagonism suppress neuronal expression. We also provide evidence soluble enhances astrocytic aerobic glycolysis hindering pyruvate...
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